Reactome | E2F8 [nucleoplasm]

E2F8 [nucleoplasm]

Stable Identifier

R-HSA-8952990

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor E2F8, E2F8_HUMAN, E2F-8

Locations in the PathwayBrowser for interactor UniProt:Q7Z412 PEX26

Expand all

External Reference Information

External Reference

UniProt:A0AVK6 E2F8

Gene Names

E2F8

Chain

chain:1-867

Reference Genes

BioGPS Gene:79733 E2F8

COSMIC (genes):E2F8 E2F8

CTD Gene:79733 E2F8

dbSNP Gene:79733 E2F8

ENSEMBL:ENSG00000129173 E2F8

HGNC:24727 E2F8

KEGG:hsa:79733 E2F8

Monarch:79733 E2F8

NCBI Gene:79733 E2F8

OMIM:612047 E2F8

UCSC:A0AVK6 E2F8

Reference Transcript

Other Identifiers

11728957_a_at

11728958_x_at

11747943_a_at

16736638

219990_PM_at

219990_at

3365777

3365778

3365779

3365780

3365781

3365782

3365783

3365784

3365785

3365786

3365788

3365789

3365790

3365791

3365792

3365793

3365794

3365795

3365796

3365797

3365798

3365799

7947110

79733

A_23_P35871

GE82899

GO:0000122

GO:0000278

GO:0000785

GO:0000978

GO:0000981

GO:0000987

GO:0001217

GO:0001227

GO:0001890

GO:0002040

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005730

GO:0005829

GO:0006355

GO:0006357

GO:0022414

GO:0030154

GO:0032466

GO:0032877

GO:0033301

GO:0042802

GO:0043226

GO:0045944

GO:0048144

GO:0048856

GO:0060707

GO:0060718

GO:0070365

GO:0090575

GO:0140110

GO:1990837

HMNXSV003042829

ILMN_1811006

PH_hs_0005170

TC11001478.hg

g13375949_3p_at

Participates

as a component of

as an input of

Inferred To

E2f8 [nucleoplasm] (Mus musculus)

E2f8 [nucleoplasm] (Rattus norvegicus)

E2F8 [nucleoplasm] (Bos taurus)

E2F8 [nucleoplasm] (Canis familiaris)

E2F8 [nucleoplasm] (Sus scrofa)

e2f8 [nucleoplasm] (Danio rerio)

e2f8 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001243300.1, NP_078956.2, NP_001243301.1

OpenTargets

ENSG00000129173

ENSEMBL

ENSP00000434199, ENST00000527884, ENSP00000250024, ENST00000620009, ENSP00000481103, ENST00000250024

HPA

ENSG00000129173-E2F8

PRO

A0AVK6

Pharos - Targets

A0AVK6

GlyGen

A0AVK6

PDB

4YO2

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13643 FHL3			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:Q92870-2 Q928702			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:Q12800 TFCP2			0.556	3
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:P07550 ADRB2	5	ADRB2 [plasma membrane] (R-HSA-390647) pS-ADRB2 [plasma membrane] (R-HSA-8852158) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) ADRB2 [endosome membrane] (R-HSA-6783036) pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143)	0.556	3
UniProt:Q7Z412 PEX26	2	PEX26 [cytosol] (R-HSA-9603779) PEX26 [peroxisomal membrane] (R-HSA-9033092)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:Q96AV8 E2F7	1	E2F7 [nucleoplasm] (R-HSA-6798305)	0.524	4

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