E2F7 forms homodimers

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

E2F7 forms homodimers (Di Stefano et al. 2003, Logan et al. 2004). While E2F7 also forms heterodimers with E2F8, co-immunoprecipitation experiments suggest that E2F7 has higher affinity for itself than for E2F8 (Li et al. 2008)

Literature References
PubMed ID Title Journal Year
18194653 Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development

Siddiqui, H, Ran, C, Li, J, de Bruin, A, Chen, HZ, Li, E, Kornacker, K, Pandit, SK, Khanizadeh, M, Liu, CG, Gordon, F, Cleghorn, W, Leone, G, Comstock, G, Weinstein, M

Dev. Cell 2008
14633988 E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

Helin, K, Jensen, MR, Di Stefano, L

EMBO J. 2003
15133492 E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains

Reilly, C, Delavaine, L, Graham, A, Wilson, J, Logan, N, Brummelkamp, TR, La Thangue, NB, Bernards, R, Hijmans, EM

Oncogene 2004
Orthologous Events
Cite Us!