Reactome | DNPH1 hydrolyses dGMP

DNPH1 hydrolyses dGMP

Stable Identifier

R-HSA-8953339

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (DNPH1 aka c-Myc-responsive protein RCL) is a cytosolic protein which catalyses the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate (2DORP) and a purine or pyrimidine base. Of the six 2'-deoxynucleoside 5'-monophosphates, DNPH1 has highest affinity for the purine deoxynucleotide dGMP (Amiable et al. 2013). The same affinity for purine deoxynucleotides over pyrimidine deoxynucleotides was observed for rat Dnph1 (Ghiorghi et al. 2007). DNPH1 is a potential target for anti-cancer therapies (Amiable et al. 2014) as it is involved in cellular proliferation and is up-regulated in several types of cancer.

Literature References

PubMed ID	Title	Journal	Year
25108359	6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities Pochet, S, Padilla, A, Haouz, A, Amiable, C, Paoletti, J, Labesse, G, Kaminski, PA	Eur J Med Chem	2014
17234634	The c-Myc target gene Rcl (C6orf108) encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase Kaminski, PA, Dang, CV, Zeller, KI, Ghiorghi, YK	J. Biol. Chem.	2007
24260472	N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1 Pochet, S, Padilla, A, Amiable, C, Kaminski, PA, Labesse, G	PLoS ONE	2013