PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix

Stable Identifier
R-HSA-8953430
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal membrane
Synonyms
glycolate(in) = glycolate(out)
ReviewStatus
5/5
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PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix
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Peroxisomal membrane protein 2 (PXMP2) homotrimer is inferred from the properties of its mouse homolog to form a channel in the peroxisomal membrane that allows the passage of glycolate and other molecules with molecular masses less than 200 Da between the cytosol and the peroxisomal matrix (Rokka et al. 2009; Wanders et al. 2016).
Literature References
PubMed ID Title Journal Year
26858947 Metabolic Interplay between Peroxisomes and Other Subcellular Organelles Including Mitochondria and the Endoplasmic Reticulum

Wanders, RJA, Waterham, HR, Ferdinandusse, S

Front Cell Dev Biol 2015
19352492 Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane

Rokka, A, Antonenkov, VD, Soininen, R, Immonen, HL, Pirilä, PL, Bergmann, U, Sormunen, RT, Weckström, M, Benz, R, Hiltunen, JK

PLoS ONE 2009
Participants
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Output
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as an event of
Event Information
Go Biological Process
carboxylic acid transport (0046942)
Catalyst Activity

channel activity of PXMP2 trimer [peroxisomal membrane]

Physical Entity
PXMP2 trimer [peroxisomal membrane] (Homo sapiens)
Activity
channel activity (GO:0015267)
Inferred From
Pxmp2 trimer transports glycolate from cytosol to peroxisomal matrix (Mus musculus)
Cross References
RHEA
Authored
D'Eustachio, P  (2016-12-23)
Reviewed
Jassal, B  (2016-12-23)
Created
D'Eustachio, P  (2016-12-23)
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