IMPAD1 hydrolyses PAP to AMP

Stable Identifier
R-HSA-8953499
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Sulfur is an essential element in all lifeforms used in the synthesis of sulfur-containing amino acids, maintenance of cellular redox states and detoxifying toxic compounds. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) is the active form of sulfur used in these reactions, which consume PAPS, producing 3'-phosphoadenosine 5'-phosphate (PAP). PAP is degraded to 5′-AMP (AMP) by 3′-nucleotidase family. Mammals encode two 3′-nucleotidases, the Golgi-resident inositol monophosphatase 3 (IMPAD3 aka PAP phosphatase, gPAPP) and the cytosolic bisphosphate 3′-nucleotidase 1 (BPNT1, described in its own reaction). Both require Mg2+ as cofactor and both are inhibited by lithium (Hudson et al. 2013).
Literature References
PubMed ID Title Journal Year
23479625 Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis

Hudson, BH, Frederick, JP, Drake, LY, York, JD, Irving, RP, Megosh, LC

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Participates
Catalyst Activity

3'(2'),5'-bisphosphate nucleotidase activity of IMPAD1:Mg2+ [Golgi lumen]

This event is regulated
Negatively by
Regulator
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!