Reactome | PHB2 [mitochondrial inner membrane]

PHB2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-8953721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Prohibitin-2, PHB2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99623 PHB2

Gene Names

PHB2, BAP, REA

Chain

initiator methionine:, chain:2-299

Reference Genes

BioGPS Gene:11331 PHB2

COSMIC (genes):PHB2 PHB2

CTD Gene:11331 PHB2

dbSNP Gene:11331 PHB2

ENSEMBL:ENSG00000215021 PHB2

HGNC:30306 PHB2

KEGG:hsa:11331 PHB2

Monarch:11331 PHB2

NCBI Gene:11331 PHB2

OMIM:610704 PHB2

UCSC:Q99623 PHB2

Reference Transcript

Other Identifiers

11331

11715383_a_at

11715384_x_at

11753313_a_at

16760649

17118890

201600_PM_at

201600_at

3442395

3442397

3442398

3442399

3442400

3442401

3442402

3442403

3442404

3442405

3442406

3442407

3442408

3442409

3442410

3442411

3442412

3442413

3442414

3442415

3442416

3442417

3442418

3442419

3442420

3442421

3442422

3442423

3442424

37364_at

7960716

7960728

A_23_P151106

A_33_P3224307

A_33_P3368328

GE54942

GO:0000423

GO:0002376

GO:0002639

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005739

GO:0005741

GO:0005743

GO:0005886

GO:0006355

GO:0006396

GO:0006606

GO:0006886

GO:0006913

GO:0006914

GO:0007005

GO:0007062

GO:0008289

GO:0009986

GO:0014069

GO:0016020

GO:0016363

GO:0016477

GO:0030331

GO:0030424

GO:0030520

GO:0031536

GO:0032991

GO:0033147

GO:0033218

GO:0033598

GO:0033600

GO:0035632

GO:0039529

GO:0042113

GO:0042802

GO:0042803

GO:0043066

GO:0043226

GO:0043433

GO:0045892

GO:0046625

GO:0046982

GO:0048786

GO:0048856

GO:0048870

GO:0050821

GO:0051091

GO:0060744

GO:0060749

GO:0060762

GO:0070374

GO:0071300

GO:0071456

GO:0071944

GO:0098542

GO:0098800

GO:0098978

GO:0098982

GO:0140374

GO:1900208

GO:1901224

GO:1902808

GO:1904959

HMNXSV003014427

HMNXSV003058162

ILMN_1696087

PH_hs_0025971

RNA33415|snoRNA_scaRNA_8_270

TC12001153.hg

TC12001154.hg

TC12002730.hg

U72511_at

U72512_at

g6005853_3p_at

Participates

as a component of

Inferred To

phb2a [mitochondrial inner membrane] (Danio rerio)

phb2 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

phb2 [mitochondrial inner membrane] (Xenopus tropicalis)

phb-2 [mitochondrial inner membrane] (Caenorhabditis elegans)

phbB [mitochondrial inner membrane] (Dictyostelium discoideum)

PHB2 [mitochondrial inner membrane] (Bos taurus)

PHB2 [mitochondrial inner membrane] (Canis familiaris)

PHB2 [mitochondrial inner membrane] (Gallus gallus)

PHB2 [mitochondrial inner membrane] (Plasmodium falciparum)

PHB2 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

PHB2 [mitochondrial inner membrane] (Sus scrofa)

Phb2 [mitochondrial inner membrane] (Drosophila melanogaster)

Phb2 [mitochondrial inner membrane] (Mus musculus)

Phb2 [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000535923, ENSP00000441875, ENST00000440277, ENSP00000412856

OpenTargets

ENSG00000215021

HPA

ENSG00000215021-PHB2

PRO

Q99623

Pharos - Targets

Q99623

GlyGen

Q99623

PDB

8J4I, 6IQE

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35232 PHB	2	PHB [cytosol] (R-HSA-5672944) PHB [mitochondrial inner membrane] (R-HSA-8953720)	0.589	3
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.527	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.508	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12