Reactome | E2F6 binds the PRC1 complex

E2F6 binds the PRC1 complex

Stable Identifier

R-HSA-8954082

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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E2F6, presumably in complex with TFDP1 (DP-1) or TFDP2 (DP-2), interacts with components of the Polycomb group (PcG) complex PRC1: BMI1, RYBP, RING1 (RING1A), PCGF2 (MEL-18) and PHC1 (mPH1) (Trimarchi et al. 2001), as well as PHC3 (Deshpande et al. 2007). The PRC1 complex may contribute to E2F6-mediated transcriptional repression. PHC3 exhibits frequent loss of heterozygosity (LoH) in primary human osteosarcoma tumors (Deshpande et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17001316	PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors Reveles, XT, Leach, RJ, Patel, BB, Naylor, SL, Akunowicz, JD, Gorlick, RG, Saria, EA, Hansen, MF, Deshpande, AM	Oncogene	2007
11171983	The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex Wen, J, Lees, JA, Fairchild, B, Trimarchi, JM	Proc. Natl. Acad. Sci. U.S.A.	2001