CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen

Stable Identifier
R-HSA-8954199
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen
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The complex of ERBB4s80 and activated estrogen receptor ESR1 promotes transcription of the CXCL12 gene, encoding Stromal cell-derived factor 1 (SDF1) (Zhu et al. 2006).

Literature References
PubMed ID Title Journal Year
16912174 Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells

Nair, SS, Vadlamudi, RK, Marrero, L, Zhu, Y, Jones, FE, Williams, CC, Pandey, AK, Sullivan, LL

Cancer Res 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ERBB4s80:ESR1:estrogen:CXCL12 gene [nucleoplasm] (Homo sapiens)
Active Unit
ERBB4s80:ESR1:estrogen [nucleoplasm]
Authored
Orlic-Milacic, M  (2011-11-04)
Stern, DF  (2019-02-21)
Reviewed
Zeng, F  (2011-11-11)
Harris, RC  (2011-11-11)
Earp HS, 3rd  (2012-02-20)
Misior, AM  (2012-02-20)
Created
Orlic-Milacic, M  (2017-01-05)
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