N-acetylaspartate (NAA) is a highly abundant brain metabolite which delivers the acetate moiety for synthesis of acetyl-CoA, further utilised for fatty acid generation. In the mitochondrial matrix of neuronal cells, N-acetylaspartate synthetase (NAT8L) catalyses the formation of NAA from acetyl-CoA (Ac-CoA) and L-aspartatic acid (L-Asp) (Wiame et al. 2009, Pessentheiner et al. 2013, Prokesch et al. 2016).
Uno, K, Groschner, LN, Bogner-Strauss, JG, Kolb, D, Miyazaki, T, Schweiger, M, Pessentheiner, AR, Walenta, E, Prokesch, A, Pelzmann, HJ, Nitta, A, Graier, WF, Rieder, D
Pospisilik, JA, Schittmayer, M, Drougard, A, Pessentheiner, AR, Birner-Gruenberger, R, Pelzmann, HJ, Bogner-Strauss, JG, Huber, K, Kolb, D, Madreiter-Sokolowski, CT, Graier, WF, Prokesch, A, Magnes, C, Trausinger, G
Courtoy, PJ, Pierrot, N, Collard, F, Wiame, E, Vincent, MF, Noel, G, Tyteca, D, Amyere, M, Desmedt, J, Boltshauser, E, Vikkula, M, Van Schaftingen, E, Octave, JN, Nassogne, MC
aspartate N-acetyltransferase activity of NAT8L [mitochondrial matrix]
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