Reactome | MVB12A [endosome membrane]

MVB12A [endosome membrane]

Stable Identifier

R-HSA-8955360

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Multivesicular body subunit 12A, CIN85/CD2AP family-binding protein, ESCRT-I complex subunit MVB12A, FAM125A, CFBP, MB12A_HUMAN

Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Endosomal Sorting Complex Required For Transport (ESCRT) (Homo sapiens)
    - Cargo Recognition And Sorting (Homo sapiens)
      - ESCRT-I [endosome membrane] (Homo sapiens)
        
        MVB12,UBAP1 [endosome membrane] (Homo sapiens)
        
        MVB12 [endosome membrane] (Homo sapiens)
        
        MVB12A [endosome membrane] (Homo sapiens)
      - ESCRT-I/Cargo Complex [endosome membrane] (Homo sapiens)
        
        ESCRT-I [endosome membrane] (Homo sapiens)
        
        MVB12,UBAP1 [endosome membrane] (Homo sapiens)
        
        MVB12 [endosome membrane] (Homo sapiens)
        
        MVB12A [endosome membrane] (Homo sapiens)
    - Cargo Sequestration (Homo sapiens)
      - ESCRT-I [endosome membrane] (Homo sapiens)
        
        MVB12,UBAP1 [endosome membrane] (Homo sapiens)
        
        MVB12 [endosome membrane] (Homo sapiens)
        
        MVB12A [endosome membrane] (Homo sapiens)
      - ESCRT-I/Cargo Complex [endosome membrane] (Homo sapiens)
        
        ESCRT-I [endosome membrane] (Homo sapiens)
        
        MVB12,UBAP1 [endosome membrane] (Homo sapiens)
        
        MVB12 [endosome membrane] (Homo sapiens)
        
        MVB12A [endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96EY5 MVB12A

Gene Names

MVB12A, CFBP, FAM125A

Chain

chain:1-273

Reference Genes

BioGPS Gene:93343 MVB12A

COSMIC (genes):MVB12A MVB12A

CTD Gene:93343 MVB12A

dbSNP Gene:93343 MVB12A

ENSEMBL:ENSG00000141971 MVB12A

HGNC:25153 MVB12A

KEGG:hsa:93343 MVB12A

Monarch:93343 MVB12A

NCBI Entrez Gene:93343 MVB12A

UCSC:Q96EY5 MVB12A

Reference Transcript

RefSeq:NM_138401.4 MVB12A

Other Identifiers

11722921_a_at

16859509

227864_PM_s_at

227864_s_at

3824302

3824304

3824306

3824311

3824318

3824319

3824320

3824321

3824322

3824323

3824324

3824325

3824326

3824327

3824328

3824329

3824330

3824331

3824332

3824333

3824334

3824335

3824336

3824337

3824338

3824339

45535_at

48058_at

8026751

93343

A_14_P108682

A_14_P119875

A_14_P124414

A_23_P393758

A_33_P3291732

GE554036

GO:0000813

GO:0005515

GO:0005634

GO:0005737

GO:0005768

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006886

GO:0008289

GO:0010008

GO:0015031

GO:0016020

GO:0016192

GO:0016236

GO:0017124

GO:0019075

GO:0031902

GO:0031982

GO:0032510

GO:0032801

GO:0036258

GO:0039702

GO:0042058

GO:0043130

GO:0043162

GO:0043226

GO:0043328

GO:0046755

GO:0061024

GO:0070062

GO:0090148

HMNXSV003008087

Hs.106597.1.A1_3p_a_at

ILMN_2121207

PH_hs_0024769

PH_hs_0039473

TC19000335.hg

TC19002021.hg

p8609

p8611

Participates

as a member of

MVB12 [endosome membrane] (Homo sapiens)

Inferred To

MVB12A [endosome membrane] (Bos taurus)

MVB12A [endosome membrane] (Canis familiaris)

MVB12A [endosome membrane] (Gallus gallus)

MVB12A [endosome membrane] (Sus scrofa)

Mvb12 [endosome membrane] (Drosophila melanogaster)

mvb-12 [endosome membrane] (Caenorhabditis elegans)

Mvb12a [endosome membrane] (Mus musculus)

Mvb12a [endosome membrane] (Rattus norvegicus)

mvb12a [endosome membrane] (Danio rerio)

Cross References

RefSeq

NP_612410.1

ENSEMBL

ENSP00000324810, ENST00000317040, ENSG00000141971

OpenTargets

ENSG00000141971

GeneCards

MVB12A

HPA

ENSG00000141971-MVB12A

PRO

Q96EY5

Pharos - Targets

Q96EY5

PDB

6VME

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.643	3
UniProt:Q15078 CDK5R1	4	CDK5R1(99-307) [nucleoplasm] (R-HSA-6805262) MyrG-CDK5R1(2-307) [plasma membrane] (R-HSA-421083) CDK5R1(99-307) [cytosol] (R-HSA-8863415) MyrG-CDK5R1(2-98) [plasma membrane] (R-HSA-8863400)	0.527	2

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