Reactome | OBSL1 [cytosol]

OBSL1 [cytosol]

Stable Identifier

R-HSA-8955929

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Obscurin-like protein 1, OBSL1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75147 OBSL1

Gene Names

OBSL1, KIAA0657

Chain

chain:1-1896

Reference Genes

BioGPS Gene:23363 OBSL1

COSMIC (genes):OBSL1 OBSL1

CTD Gene:23363 OBSL1

dbSNP Gene:23363 OBSL1

ENSEMBL:ENSG00000124006 OBSL1

HGNC:29092 OBSL1

KEGG:hsa:23363 OBSL1

Monarch:23363 OBSL1

NCBI Gene:23363 OBSL1

OMIM:610991 OBSL1

UCSC:O75147 OBSL1

Reference Transcript

Participates

as a component of

CUL7:CCDC8:OBSL1 [cytosol] (Homo sapiens)

Inferred To

OBSL1 [cytosol] (Bos taurus)

OBSL1 [cytosol] (Canis familiaris)

OBSL1 [cytosol] (Gallus gallus)

OBSL1 [cytosol] (Sus scrofa)

Obsl1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_056126.1, NP_001166902.1, NP_001166879.1

OpenTargets

ENSG00000124006

ENSEMBL

ENSP00000385636, ENSP00000474519, ENSP00000362980, ENST00000603926, ENSG00000124006, ENST00000373873, ENST00000404537

HPA

ENSG00000124006-OBSL1

GeneCards

OBSL1

PRO

O75147

Pharos - Targets

O75147

Orphanet

OBSL1

GlyGen

O75147

PDB

2WWM, 2E6P, 2LU7, 2E6Q, 2WP3, 2CPC, 3KNB, 2WWK, 2LVC, 5FM5

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16539 MAPK14	7	p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [cytosol] (R-HSA-428933) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280)	0.788	5
UniProt:Q96RR4 CAMKK2	4	p-CAMKK2 [nucleoplasm] (R-HSA-9618968) CAMKK2 [nucleoplasm] (R-HSA-5336483) CAMKK2 [cytosol] (R-HSA-9619231) p-CAMKK2 [cytosol] (R-HSA-9619358)	0.643	3
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518)	0.527	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.527	2
UniProt:Q6NZI2 CAVIN1	2	PTRF [nucleoplasm] (R-HSA-74981) CAVIN1 [plasma membrane] (R-HSA-9714278)	0.527	2
UniProt:P43353 ALDH3B1	3	ALDH3B1 [plasma membrane] (R-HSA-5696096) ALDH3B1 [secretory granule membrane] (R-HSA-6801023) ALDH3B1 [specific granule membrane] (R-HSA-6799510)	0.527	3

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