Reactome | ub-BIRC5 [cytosol]

ub-BIRC5 [cytosol]

Stable Identifier

R-HSA-8955933

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Survivin, Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor survivin, Apoptosis inhibitor 4

Locations in the PathwayBrowser for interactor UniProt:Q7Z412 PEX26

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External Reference Information

External Reference

UniProt:O15392 BIRC5

Gene Names

BIRC5, API4, IAP4

Chain

chain:1-142

Reference Genes

COSMIC (genes):BIRC5 BIRC5

dbSNP Gene:332 BIRC5

ENSEMBL:ENSG00000089685 BIRC5

Participates

as an output of

CUL9:RBX1 ubiquitinates BIRC5 (Homo sapiens)

Other forms of this molecule

BIRC5 [cytosol]

BIRC5 [nucleoplasm]

Inferred To

ub-BIRC5 [cytosol] (Bos taurus)

ub-BIRC5 [cytosol] (Caenorhabditis elegans)

ub-BIRC5 [cytosol] (Rattus norvegicus)

ub-BIRC5 [cytosol] (Saccharomyces cerevisiae)

ub-BIRC5 [cytosol] (Sus scrofa)

ub-BIRC5 [cytosol] (Xenopus tropicalis)

AFMID [cytosol] (Canis familiaris)

Homologues of ub-BIRC5 [cytosol] (Caenorhabditis elegans)

BIRC5 [cytosol] (Gallus gallus)

Det [cytosol] (Drosophila melanogaster)

Modified Residues

Name

ubiquitinylated lysine (polyubiquitin chain [cytosol]) at unknown position

Modification

polyubiquitin chain [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q53HL2 CDCA8	3	polySUMO2,3-CDCA8 [cytosol] (R-HSA-4655328) CDCA8 [nucleoplasm] (R-HSA-4655357) CDCA8 [cytosol] (R-HSA-375288)	0.964	21
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.952	13
UniProt:Q9NQS7 INCENP	2	INCENP [nucleoplasm] (R-HSA-4655393) INCENP [cytosol] (R-HSA-375311)	0.918	11
IntAct:EBI-15634422 H3K9-2			0.76	8
UniProt:Q9UQB9 AURKC			0.739	10
ChEBI:78766 LLP-3			0.642	4
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.635	7
IntAct:EBI-15949926 HSGO1			0.618	3
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.609	2
UniProt:Q86XJ1 GA2L3			0.558	4
IntAct:EBI-15963608 SMACN			0.558	2
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:Q92870-2 Q928702			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.556	3
UniProt:Q9BXM7 PINK1	5	PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628) PINK1 [cytosol] (R-HSA-5205637) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [mitochondrial outer membrane] (R-HSA-5205653) p-S228,S402-PINK1 [mitochondrial outer membrane] (R-HSA-9834051)	0.556	3
UniProt:Q15834 CC85B			0.556	3
UniProt:Q8TB36 GDAP1	2	GDAP1 [peroxisomal membrane] (R-HSA-9603788) GDAP1 [cytosol] (R-HSA-9603796)	0.556	3
UniProt:Q7Z412 PEX26	2	PEX26 [cytosol] (R-HSA-9603779) PEX26 [peroxisomal membrane] (R-HSA-9033092)	0.556	3
UniProt:P05067-2 APP			0.556	3
UniProt:P55211 CASP9	5	CASP9(1-416) [cytosol] (R-HSA-57033) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(331-416) [cytosol] (R-HSA-141639) p-T412-CASP9(1-416) [cytosol] (R-HSA-9627087) p-S196-CASP9(1-416) [cytosol] (R-HSA-198636)	0.536	2
UniProt:Q96A19 C102A			0.527	2
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.527	2
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.527	2
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.527	2
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	2
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.527	2
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.527	2
UniProt:O75586 MED6	1	MED6 [nucleoplasm] (R-HSA-212359)	0.527	2
UniProt:Q0VGL1 LAMTOR4	1	LAMTOR4 [lysosomal membrane] (R-HSA-5655432)	0.527	2
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.527	2
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.527	2
UniProt:P02008 HBAZ			0.527	2
UniProt:A1L4H1 SSC5D	1	SSC5D [extracellular region] (R-HSA-8878615)	0.527	2
UniProt:Q9BUE0 MED18	1	MED18 [nucleoplasm] (R-HSA-556826)	0.527	2
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.525	2
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.524	3
UniProt:O14980 XPO1	2	XPO1 [cytosol] (R-HSA-165539) XPO1 [nucleoplasm] (R-HSA-165529)	0.524	2
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.463	6

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