Reactome | NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1

NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1

Stable Identifier

R-HSA-8956050

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CUL7, CCDC8 and OBSL1 are part of a 3M complex that has roles in maintenace of genome stability and microtubule dynamics (Li et al, 2014; Yan et al, 2014). The 3M complex inhibits CUL9-mediated ubiquitination of BIRC5 through the formation of a CUL9:CUL7 heterodimer (Skaar et al, 2007; Li et al, 2014)

Literature References

PubMed ID	Title	Journal	Year
17332328	PARC and CUL7 form atypical cullin RING ligase complexes Tron, A, Florens, L, Tsutsumi, T, Skaar, JR, Swanson, SK, Arai, T, DeCaprio, JA, Washburn, MP	Cancer Res.	2007
24793695	The 3M complex maintains microtubule and genome integrity Yu, Y, Chen, X, Sinnott, B, Yan, J, Li, Z, Xiong, Y, Yan, F, Cormier-Daire, V, Cappell, KM, Whitehurst, AW, Mo, J, Duncan, JA	Mol. Cell	2014
24793696	CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity Pei, XH, Yan, J, Li, Z, Xiong, Y, Yan, F, Cappell, KM, Whitehurst, AW	Mol. Cell	2014