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monoSUMO1-K1971-CHD3 [nucleoplasm]
Stable Identifier
R-HSA-8956372
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Chromodomain-helicase-DNA-binding protein 3, CHD3_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q16891 IMMT
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Homo sapiens)
monoSUMO1-K1971-CHD3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12873 CHD3
Gene Names
CHD3
Chain
chain:1-2000
Reference Genes
BioGPS Gene:1107 CHD3
COSMIC (genes):CHD3 CHD3
CTD Gene:1107 CHD3
dbSNP Gene:1107 CHD3
ENSEMBL:ENSG00000170004 CHD3
ENSEMBL_homo_sapiens_GENE:ENSG00000170004.19 CHD3
HGNC:1918 CHD3
KEGG Gene (Homo sapiens):1107 CHD3
Monarch:1107 CHD3
NCBI Gene:1107 CHD3
OMIM:602120 CHD3
UCSC:Q12873 CHD3
Reference Transcript
RefSeq:NM_001005271.2 CHD3
RefSeq:NM_005852.3 CHD3
RefSeq:NM_001005273.2 CHD3
Other Identifiers
1107
11741293_a_at
11741605_a_at
11741606_s_at
11742704_a_at
11750714_a_at
16830789
208806_PM_at
208806_at
208807_PM_s_at
208807_s_at
34707_at
3709247
3709252
3709253
3709254
3709255
3709259
3709260
3709261
3709262
3709263
3709264
3709265
3709266
3709267
3709268
3709269
3709271
3709272
3709273
3709274
3709275
3709276
3709277
3709280
3709281
3709282
3709283
3709284
3709285
3709286
3709287
3709288
3709289
3709292
3709293
3709295
3709296
3709298
3709299
3709300
3709302
3709304
3709306
3709308
3709310
3709312
3709315
3709317
3709318
3709319
3709320
3709321
3709322
3709323
3709324
3709326
51090_at
8004699
89504_at
A_33_P3239287
GO:0000122
GO:0000166
GO:0000785
GO:0000976
GO:0003677
GO:0003682
GO:0003723
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0007010
GO:0007051
GO:0007098
GO:0008270
GO:0016581
GO:0016605
GO:0016787
GO:0016887
GO:0030154
GO:0034451
GO:0042393
GO:0042659
GO:0043226
GO:0045892
GO:0045893
GO:0046872
GO:0140097
GO:0140657
GO:0140658
GO:2000736
HMNXSV003024425
HMNXSV003036814
Hs.25601.1.S2_3p_at
ILMN_1740764
ILMN_2370414
PH_hs_0002256
PH_hs_0040667
TC17000120.hg
g3298561_3p_a_at
Participates
as an output of
ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Homo sapiens)
Other forms of this molecule
CHD3 [nucleoplasm]
Inferred To
monoSUMO1-K1971-CHD3 [nucleoplasm]
(Caenorhabditis elegans)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(Schizosaccharomyces pombe)
Chd3 [nucleoplasm]
(Mus musculus)
Chd3 [nucleoplasm]
(Rattus norvegicus)
CHD3 [nucleoplasm]
(Bos taurus)
CHD3 [nucleoplasm]
(Sus scrofa)
Homologues of monoSUMO1-K1971-CHD3 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 1971
Coordinate
1971
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001005271.2
,
NP_005843.2
,
NP_001005273.1
OpenTargets
ENSG00000170004
GeneCards
Q12873
HPA
ENSG00000170004-CHD3
Ensembl
ENST00000358181
,
ENST00000380358
,
ENSP00000369716
,
ENSP00000332628
,
ENSP00000350907
,
ENSG00000170004
,
ENST00000330494
PRO
Q12873
Pharos - Targets
Q12873
Orphanet
29264
HMDB Protein
HMDBP11640
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.805
9
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.788
8
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.725
5
UniProt:O14519 CDKA1
0.725
6
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.677
8
UniProt:P61956 SUMO2
6
lysyl-G93-SUMO2 [cytosol]
(R-HSA-9834803)
SUMO2(1-95) [nucleoplasm]
(R-HSA-2990837)
UBA2-G93-SUMO2 [nucleoplasm]
(R-HSA-3730618)
SUMO2 [nucleoplasm]
(R-HSA-2984281)
UBE2I-G93-SUMO2 [nucleoplasm]
(R-HSA-3730625)
lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm]
(R-HSA-9761546)
0.668
3
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.597
4
UniProt:Q8NC51 SERB1
0.581
5
UniProt:O94776 MTA2
1
MTA2 [nucleoplasm]
(R-HSA-4657009)
0.577
5
UniProt:Q13263 TRIM28
3
SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm]
(R-HSA-3782600)
TRIM28 [nucleoplasm]
(R-HSA-974998)
SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm]
(R-HSA-9842867)
0.573
4
UniProt:Q5JVS0 HABP4
2
HABP4 [extracellular region]
(R-HSA-448329)
HABP4 [cytosol]
(R-HSA-448328)
0.553
2
UniProt:Q8N6T7 SIRT6
1
SIRT6 [nucleoplasm]
(R-HSA-5685963)
0.553
2
UniProt:Q9NRH1 YAE1
0.553
2
UniProt:P21246 PTN
1
PTN [extracellular region]
(R-HSA-201500)
0.553
2
UniProt:P02766 TTR
2
TTR [azurophil granule lumen]
(R-HSA-6799366)
TTR [extracellular region]
(R-HSA-976883)
0.553
2
UniProt:Q16891 IMMT
1
IMMT (MIC60) [mitochondrial inner membrane]
(R-HSA-8949569)
0.553
2
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.527
3
UniProt:Q86YP4 GATAD2A
1
GATAD2A [nucleoplasm]
(R-HSA-3702077)
0.527
4
UniProt:Q8WXI9 GATAD2B
1
GATAD2B [nucleoplasm]
(R-HSA-3702079)
0.527
5
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.527
3
UniProt:O95365 ZBT7A
0.508
2
UniProt:Q99728 BARD1
13
BARD1 G623E [nucleoplasm]
(R-HSA-9699135)
BARD1 C71Y [nucleoplasm]
(R-HSA-9700808)
BARD1 C53W [nucleoplasm]
(R-HSA-9700807)
BARD1 G623W [nucleoplasm]
(R-HSA-9699148)
BARD1 W34R [nucleoplasm]
(R-HSA-9699166)
BARD1 H68Y [nucleoplasm]
(R-HSA-9699151)
BARD1 L44R [nucleoplasm]
(R-HSA-9699126)
BARD1 C50G [nucleoplasm]
(R-HSA-9699137)
BARD1 C83G [nucleoplasm]
(R-HSA-9699139)
K6PolyUb-BARD1 [nucleoplasm]
(R-HSA-9701024)
K6PolyUb,p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-9707286)
p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-5659846)
BARD1 [nucleoplasm]
(R-HSA-5659775)
0.508
2
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.508
3
UniProt:O75400 PRPF40A
1
PRPF40A [nucleoplasm]
(R-HSA-8867890)
0.508
2
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.508
2
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.499
4
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