Reactome | RNLS:FAD oxidises dh-beta-NAD to NAD+

RNLS:FAD oxidises dh-beta-NAD to NAD+

Stable Identifier

R-HSA-8956458

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Renalase (RNLS) is a flavoprotein that is secreted by the kidney and circulates in blood from where it can regulate blood pressure, regulate sodium and phosphate excretion and display cardioprotectivity through a mechanism which is not understood to date. RNLS, using FAD as cofactor, can oxidise isomeric forms of beta-NAD(P)H that can arise either by nonspecific reduction of beta-NAD(P)+ or by tautomerisation of beta-NAD(P)H (Milani et al. 2011, Beaupre et al. 2015). These forms are 1,2- and 1,6-dihydroNAD(P) (dh-beta-NAD(P)) and are potent inhibitors of primary metabolism dehydrogenases. RNLS may thus play a role in eliminating these isomeric forms which threaten normal respiratory activity.

Literature References

PubMed ID	Title	Journal	Year
25531177	Metabolic function for human renalase: oxidation of isomeric forms of β-NAD(P)H that are inhibitory to primary metabolism Moran, GR, Roman, J, Försterling, FH, Hoag, MR, Beaupre, BA	Biochemistry	2015
21699903	FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation Aliverti, A, Bolognesi, M, Baroni, S, Canevari, G, Ciriello, F, Milani, M, Pandini, V	J. Mol. Biol.	2011