Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TAL1 [nucleoplasm]
Stable Identifier
R-HSA-8956511
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
T-cell acute lymphocytic leukemia protein 1, TAL1_HUMAN, SCL, TCL5, BHLHA17
Locations in the PathwayBrowser for interactor UniProt:P14921 ETS1
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)
TAL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17542 TAL1
Gene Names
TAL1, BHLHA17, SCL, TCL5
Chain
chain:1-331
Reference Genes
BioGPS Gene:6886 TAL1
COSMIC (genes):TAL1 TAL1
CTD Gene:6886 TAL1
dbSNP Gene:6886 TAL1
ENSEMBL:ENSG00000162367 TAL1
HGNC:11556 TAL1
KEGG:hsa:6886 TAL1
Monarch:6886 TAL1
NCBI Gene:6886 TAL1
OMIM:187040 TAL1
UCSC:P17542 TAL1
Reference Transcript
RefSeq:NM_001290404.1 TAL1
RefSeq:NM_001287347.2 TAL1
RefSeq:XM_017002189.1 TAL1
RefSeq:XM_017002187.1 TAL1
RefSeq:NM_001290405.1 TAL1
RefSeq:XM_017002191.1 TAL1
RefSeq:XM_017002190.1 TAL1
RefSeq:NM_003189.5 TAL1
RefSeq:NM_001290406.1 TAL1
RefSeq:NM_001290403.1 TAL1
RefSeq:XM_017002188.1 TAL1
RefSeq:XM_005271160.4 TAL1
Other Identifiers
11725898_s_at
1561651_PM_s_at
1561651_s_at
16686784
206283_PM_s_at
206283_s_at
216925_PM_s_at
216925_s_at
2411195
2411197
2411199
2411200
2411201
2411202
2411203
2411204
2411205
2411206
2411207
2411208
2411209
2411211
2411212
2411213
2411215
2411216
2411219
2411220
2411221
2411222
560_s_at
6886
7915919
A_23_P63371
A_24_P345314
GE56652
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001525
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0007626
GO:0019899
GO:0021527
GO:0021953
GO:0030097
GO:0030099
GO:0030154
GO:0030218
GO:0030219
GO:0030220
GO:0030221
GO:0031334
GO:0032991
GO:0035162
GO:0035855
GO:0042127
GO:0042826
GO:0043226
GO:0043249
GO:0045165
GO:0045637
GO:0045648
GO:0045893
GO:0045931
GO:0045944
GO:0046983
GO:0048699
GO:0048856
GO:0051781
GO:0060018
GO:0060216
GO:0060217
GO:0060218
GO:0060375
GO:0061629
GO:0070888
GO:0140110
GO:1904672
GO:1905269
HMNXSV003021465
Hs.73828.1.S1_3p_a_at
Hs2.407413.1.S1_3p_s_at
ILMN_1748450
M63589_at
PH_hs_0004218
TC01005458.hg
g4507362_3p_a_at
Participates
as a component of
CEBPA gene:RUNX1:SPI1:GATA2:TAL1:FLI1:MYB [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
TAL1 core complex [nucleoplasm] (Homo sapiens)
as an input of
RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)
Inferred To
HLH3B [nucleoplasm]
(Drosophila melanogaster)
TAL1 [nucleoplasm]
(Bos taurus)
TAL1 [nucleoplasm]
(Canis familiaris)
TAL1 [nucleoplasm]
(Gallus gallus)
TAL1 [nucleoplasm]
(Sus scrofa)
Tal1 [nucleoplasm]
(Mus musculus)
Tal1 [nucleoplasm]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000162367
ENSEMBL
ENSP00000360951
,
ENST00000691006
,
ENST00000371884
,
ENSP00000294339
,
ENSP00000510655
,
ENST00000294339
HPA
ENSG00000162367-TAL1
PRO
P17542
Pharos - Targets
P17542
Orphanet
TAL1
PDB
2YPB
,
2YPA
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15923 TCF3
2
p-S139-TCF3 [nucleoplasm]
(R-HSA-3209894)
TCF3 [nucleoplasm]
(R-HSA-3209896)
0.876
10
UniProt:Q99081 TCF12
1
TCF12 [nucleoplasm]
(R-HSA-445670)
0.831
7
UniProt:Q86U70 LDB1
1
LDB1 [nucleoplasm]
(R-HSA-8956515)
0.69
4
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.689
5
UniProt:Q01196 RUNX1
5
RUNX1 [plasma membrane]
(R-HSA-5667138)
p-S249,S273,S276-RUNX1 [nucleoplasm]
(R-HSA-8878063)
p-7Y-RUNX1 [nucleoplasm]
(R-HSA-8937712)
MeR206,MeR210-RUNX1 [nucleoplasm]
(R-HSA-8934750)
RUNX1 [nucleoplasm]
(R-HSA-8865295)
0.623
3
UniProt:P81877 SSBP2
0.597
3
UniProt:Q9BWW4 SSBP3
0.597
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.558
5
UniProt:O60341-1 KDM1A
0.558
5
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.527
2
UniProt:P47928 ID4
1
ID4 [nucleoplasm]
(R-HSA-3701048)
0.527
2
UniProt:P25801
1
Lmo2 [nucleoplasm]
(R-MMU-8956513)
0.527
5
UniProt:P14921 ETS1
2
ETS1 [nucleoplasm]
(R-HSA-1629809)
p-T38-ETS1 [nucleoplasm]
(R-HSA-3132720)
0.499
2
UniProt:Q9UPN9 TRIM33
1
TRIM33 [nucleoplasm]
(R-HSA-870522)
0.462
3
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.462
3
UniProt:Q92769 HDAC2
2
HDAC2 [nucleoplasm]
(R-HSA-205135)
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
0.462
3
UniProt:Q9UKL0 RCOR1
1
RCOR1 [nucleoplasm]
(R-HSA-996766)
0.462
3
UniProt:O75081 MTG16
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text