Reactome | LMO1 [nucleoplasm]

LMO1 [nucleoplasm]

Stable Identifier

R-HSA-8956514

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Rhombotin-1, RBTN1_HUMAN, RBTN1, RHOM1, TTG1, LIM domain only protein 1, T-cell translocation protein 1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
        
        MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO1 [nucleoplasm] (Homo sapiens)
        
        RUNX1 binds the core TAL1 complex (Homo sapiens)
        
        RUNX1:CBFB:TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO1 [nucleoplasm] (Homo sapiens)
        
        TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO1 [nucleoplasm] (Homo sapiens)
        
        RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LMO1,LMO2 [nucleoplasm] (Homo sapiens)
        
        LMO1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25800 LMO1

Gene Names

LMO1, RBTN1, RHOM1, TTG1

Chain

chain:1-156

Reference Genes

BioGPS Gene:4004 LMO1

COSMIC (genes):LMO1 LMO1

CTD Gene:4004 LMO1

dbSNP Gene:4004 LMO1

ENSEMBL:ENSG00000166407 LMO1

ENSEMBL_homo_sapiens_GENE:ENSG00000166407.14 LMO1

HGNC:6641 LMO1

KEGG Gene (Homo sapiens):4004 LMO1

Monarch:4004 LMO1

NCBI Gene:4004 LMO1

OMIM:186921 LMO1

UCSC:P25800 LMO1

Reference Transcript

Other Identifiers

11728452_a_at

16735366

206718_PM_at

206718_at

3361686

3361687

3361691

3361696

3361726

3361727

3361728

3361729

3361736

35103_i_at

35104_r_at

4004

7946354

GE57893

GO:0000122

GO:0002376

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0043226

GO:0045944

GO:0046013

GO:0046872

GO:0140110

GO:0140297

HMNXSV003047920

HMNXSV003056550

ILMN_1662917

M26682_at

PH_hs_0000150

TC11001385.hg

TC11003044.hg

g4505004_3p_at

Participates

as a member of

LMO1,LMO2 [nucleoplasm] (Homo sapiens)

Inferred To

Lmo1 [nucleoplasm] (Mus musculus)

Bx [nucleoplasm] (Drosophila melanogaster)

Lmo3 [nucleoplasm] (Rattus norvegicus)

LMO1 [nucleoplasm] (Bos taurus)

LMO1 [nucleoplasm] (Canis familiaris)

LMO1 [nucleoplasm] (Gallus gallus)

LMO1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_002306.1, NP_001257357.1

OpenTargets

ENSG00000166407

HPA

ENSG00000166407-LMO1

GeneCards

P25800

Ensembl

ENST00000335790, ENSP00000338207, ENSG00000166407, ENSP00000404538, ENST00000428101

PRO

P25800

Pharos - Targets

P25800

Orphanet

23742

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.781	7
UniProt:P26045 PTPN3	3	PTPN3 [plasma membrane] (R-HSA-5490317) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [cytosol] (R-HSA-8867650)	0.718	6
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.556	3
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.556	3
UniProt:P52747 ZNF143	1	ZNF143 [nucleoplasm] (R-HSA-83837)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q9NX63 CHCHD3	3	CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910) CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583)	0.556	3
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.556	3
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) CARD9 [plasma membrane] (R-HSA-5607662) p-T231-CARD9 [plasma membrane] (R-HSA-5607623)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.556	3
UniProt:P20618 PSMB1	7	PSMB1(1-28) [cytosol] (R-HSA-9908143) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3