Reactome | LDB1 [nucleoplasm]

LDB1 [nucleoplasm]

Stable Identifier

R-HSA-8956515

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

LIM domain-binding protein 1, LDB1_HUMAN, CLIM2, Carboxyl-terminal LIM domain-binding protein 2

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
        
        MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LDB1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LDB1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LDB1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LDB1 [nucleoplasm] (Homo sapiens)
        
        RUNX1 binds the core TAL1 complex (Homo sapiens)
        
        RUNX1:CBFB:TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LDB1 [nucleoplasm] (Homo sapiens)
        
        TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LDB1 [nucleoplasm] (Homo sapiens)
        
        RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LDB1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LDB1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LDB1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        LDB1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86U70 LDB1

Gene Names

LDB1, CLIM2

Chain

initiator methionine:, chain:2-411

Reference Genes

BioGPS Gene:8861 LDB1

COSMIC (genes):LDB1 LDB1

CTD Gene:8861 LDB1

dbSNP Gene:8861 LDB1

ENSEMBL:ENSG00000198728 LDB1

ENSEMBL_homo_sapiens_GENE:ENSG00000198728.11 LDB1

HGNC:6532 LDB1

KEGG Gene (Homo sapiens):8861 LDB1

Monarch:8861 LDB1

NCBI Gene:8861 LDB1

OMIM:603451 LDB1

UCSC:Q86U70 LDB1

Reference Transcript

Other Identifiers

11747711_a_at

11757821_s_at

16717869

203451_PM_at

203451_at

3304221

3304222

3304223

3304224

3304225

3304226

3304227

3304228

3304231

3304232

3304233

3304234

3304237

3304238

3304239

3304240

3304241

3304247

3304249

3304250

3304251

35160_PM_at

35160_at

4870487C_3p_at

57827_at

7935968

8861

A_23_P97892

GE54588

GO:0000122

GO:0000785

GO:0000972

GO:0001702

GO:0001942

GO:0002376

GO:0003677

GO:0003682

GO:0003713

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0006351

GO:0006355

GO:0006366

GO:0007155

GO:0007399

GO:0009948

GO:0010669

GO:0016055

GO:0019899

GO:0021549

GO:0021702

GO:0022607

GO:0023052

GO:0030154

GO:0030182

GO:0030274

GO:0030334

GO:0031252

GO:0032968

GO:0032991

GO:0034330

GO:0035019

GO:0042802

GO:0042803

GO:0043226

GO:0043549

GO:0043621

GO:0045647

GO:0045785

GO:0045892

GO:0045944

GO:0046985

GO:0048856

GO:0048870

GO:0051893

GO:0060322

GO:0061629

GO:0090575

GO:0140110

GO:0140297

GO:1990907

HMNXSV003055463

ILMN_1811347

PH_hs_0002290

TC10001617.hg

g4504968_3p_s_at

Participates

as a component of

Inferred To

LDB1 [nucleoplasm] (Bos taurus)

LDB1 [nucleoplasm] (Canis familiaris)

LDB1 [nucleoplasm] (Gallus gallus)

LDB1 [nucleoplasm] (Sus scrofa)

Chi [nucleoplasm] (Drosophila melanogaster)

Ldb1 [nucleoplasm] (Mus musculus)

Ldb1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001106878.1, NP_003884.1

OpenTargets

ENSG00000198728

GeneCards

Q86U70

HPA

ENSG00000198728-LDB1

Ensembl

ENSP00000501277, ENSP00000354616, ENST00000673968, ENSG00000198728, ENST00000361198

PRO

Q86U70

Pharos - Targets

Q86U70

PDB

2XJY, 7OB8, 8SSU, 6TYD, 2YPA, 2XJZ, 7OB5

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.597	3
UniProt:P50458 LHX2	1	LHX2 [nucleoplasm] (R-HSA-9011100)	0.594	3

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