Reactome | FN1 [endoplasmic reticulum lumen]

FN1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956708

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Fibronectin, FINC_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P02751 FN1

Gene Names

FN1, FN

Chain

signal peptide:1-31, chain:32-2477, chain:627-702, chain:723-911, chain:723-903, chain:723-

Reference Genes

COSMIC (genes):FN1 FN1

dbSNP Gene:2335 FN1

ENSEMBL:ENSG00000115414 FN1

Participates

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

FN1(32-2386) [extracellular region]

p-FN1 [endoplasmic reticulum lumen]

FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]

FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]

FN1(?-2386) [extracellular region]

FN1(32-?) [extracellular region]

FN1(272-2386) [extracellular region]

FN1(32-271) [extracellular region]

FN1(32-2386) [platelet alpha granule lumen]

Inferred To

FN1 [endoplasmic reticulum lumen] (Bos taurus)

FN1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

FN1 [endoplasmic reticulum lumen] (Canis familiaris)

FN1 [endoplasmic reticulum lumen] (Gallus gallus)

FN1 [endoplasmic reticulum lumen] (Sus scrofa)

fn1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Fn1 [endoplasmic reticulum lumen] (Mus musculus)

Fn1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02751 FN1	10	FN1(32-2386) [extracellular region] (R-HSA-54851) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620)	0.891	8
ChEBI:28304 HEPARIN			0.845	6
UniProt:P08648 ITGA5	3	ITGA5 [plasma membrane] (R-HSA-9857636) p-S-ITGA5 [plasma membrane] (R-HSA-9857662) ITGA5(42-894) [plasma membrane] (R-HSA-202735)	0.839	11
UniProt:P21980 TGM2			0.811	5
UniProt:P14738 FNBA			0.789	23
UniProt:P05106 ITGB3	3	ITGB3 [plasma membrane] (R-HSA-57600) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) p-T779-ITGB3 [plasma membrane] (R-HSA-432107)	0.75	5
UniProt:P05556 ITGB1	2	ITGB1 [plasma membrane] (R-HSA-57596) ITGB1 [endosome membrane] (R-HSA-9611157)	0.745	12
UniProt:Q53682 Q53682			0.743	19
UniProt:P06756 ITGAV	3	ITGAV(31-1048) [plasma membrane] (R-HSA-210013) ITGAV(31-1048) [specific granule membrane] (R-HSA-6806145) ITGAV(31-1048) [phagocytic vesicle] (R-HSA-1236773)	0.743	4
UniProt:Q53971 Q53971			0.719	4
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.713	3
UniProt:Q93ED6 Q93ED6			0.675	8
IntAct:EBI-2528478 COLLAGEN			0.667	5
UniProt:P29279 CTGF	1	CTGF [extracellular region] (R-HSA-561148)	0.65	5
UniProt:Q9CKF6 Q9CKF6			0.623	5
UniProt:P11684 UTER			0.618	3
UniProt:P07996 THBS1	5	THBS1 [endoplasmic reticulum lumen] (R-HSA-5173263) glc-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5172997) O-fuc-THBS1 [endoplasmic reticulum lumen] (R-HSA-5173278) THBS1 [platelet alpha granule lumen] (R-HSA-114701) THBS1 [extracellular region] (R-HSA-66518)	0.609	2
UniProt:P07585 DCN	20	XylS-DCN [Golgi lumen] (R-HSA-2064097) Gal-Xyl-DCN [Golgi lumen] (R-HSA-2064080) DCN [Golgi lumen] (R-HSA-2063995) Gal-Gal-Xyl-DCN [Golgi lumen] (R-HSA-2064064) GlcA-Gal-Gal-Xyl-DCN [Golgi lumen] (R-HSA-2064161) D2,4(S)2-DCN [Golgi lumen] (R-HSA-2065119) dermatan-DCN [Golgi lumen] (R-HSA-5607522) D4S-DCN [Golgi lumen] (R-HSA-2065089) D2,4,4(S)3-DCN [Golgi lumen] (R-HSA-2065069) chondroitin(3)-DCN [Golgi lumen] (R-HSA-2064025) C4S-DCN [Golgi lumen] (R-HSA-2064171) chondroitin(2)-DCN [Golgi lumen] (R-HSA-2063993) chondroitin(1)-DCN [Golgi lumen] (R-HSA-2064248) D2,4,4(S)3-DCN [extracellular region] (R-HSA-2065093) D2,4(S)2-DCN [extracellular region] (R-HSA-2065241) D4S-DCN [extracellular region] (R-HSA-2065254) C6S-DCN [Golgi lumen] (R-HSA-2064145) CSE-DCN [Golgi lumen] (R-HSA-2064056) C4S-DCN [extracellular region] (R-HSA-2064029) C6S-DCN [extracellular region] (R-HSA-2064182)	0.602	9
UniProt:P08519 LPA	1	LPA [extracellular region] (R-HSA-176877)	0.592	2
UniProt:Q99IB8-PRO_0000045603			0.57	3
UniProt:P13612 ITGA4	1	ITGA4 [plasma membrane] (R-HSA-198007)	0.564	3
UniProt:P98066 TNFAIP6	3	TNFAIP6 [ficolin-1-rich granule lumen] (R-HSA-6803311) TNFAIP6 [extracellular region] (R-HSA-6803348) TNFAIP6 [tertiary granule lumen] (R-HSA-6803341)	0.558	8
UniProt:P23568 EFTU			0.558	2
UniProt:P28300-PRO_0000018520 LOX			0.558	2
UniProt:Q4AAD6 Q4AAD6			0.558	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.547	2
UniProt:Q15942 ZYX			0.547	2
UniProt:O75636 FCN3	1	FCN3 [extracellular region] (R-HSA-2530443)	0.544	3
UniProt:P05154 SERPINA5	1	SERPINA5 [extracellular region] (R-HSA-5591085)	0.544	3
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.527	2
UniProt:P50395 GDI2	4	GDI2 [cytosol] (R-HSA-195089) GDI2 [azurophil granule lumen] (R-HSA-6799337) GDI2 [extracellular region] (R-HSA-6806176) GDI2 [secretory granule lumen] (R-HSA-6800904)	0.527	2
UniProt:Q601D1 Q601D1			0.524	2
UniProt:Q9NY15 STAB1	2	STAB1 [endocytic vesicle membrane] (R-HSA-2239447) STAB1 [plasma membrane] (R-HSA-2197768)	0.508	2
UniProt:Q9Y4K0 LOXL2	3	LOXL2(26-?) [extracellular region] (R-HSA-2022106) LOXL2 [extracellular region] (R-HSA-2022142) LOXL2(?-774) [extracellular region] (R-HSA-2022136)	0.506	2
UniProt:P40337 VHL	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423)	0.499	2
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.491	2
UniProt:C5MHM7 C5MHM7			0.462	2
UniProt:G8BA52 G8BA52			0.462	2
UniProt:C5MBE7 C5MBE7			0.462	2
UniProt:G8B999 G8B999			0.462	2
UniProt:C5MAS1 C5MAS1			0.462	2
UniProt:G8BE22 G8BE22			0.462	2
UniProt:G8BCH3 G8BCH3			0.462	2