Reactome | FUCA2 [endoplasmic reticulum lumen]

FUCA2 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956727

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Plasma alpha-L-fucosidase ecNumber3.2.1.51/ecNumber, FUCO2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9BTY2 FUCA2

Gene Names

FUCA2, PSEC0151, UNQ227/PRO260

Chain

signal peptide:1-28, chain:29-467

Reference Genes

BioGPS Gene:2519 FUCA2

COSMIC (genes):FUCA2 FUCA2

CTD Gene:2519 FUCA2

dbSNP Gene:2519 FUCA2

ENSEMBL:ENSG00000001036 FUCA2

HGNC:4008 FUCA2

KEGG:hsa:2519 FUCA2

Monarch:2519 FUCA2

NCBI Gene:2519 FUCA2

OMIM:136820 FUCA2

UCSC:Q9BTY2 FUCA2

Reference Transcript

RefSeq:NM_032020.4 FUCA2

Other Identifiers

11717740_a_at

11717741_x_at

11758787_at

11760727_at

17024374

223120_PM_at

223120_at

2519

2977519

2977520

2977521

2977522

2977523

2977525

2977526

2977527

2977528

2977529

2977532

2977533

2977536

2977537

2977538

2977539

48543_at

8129974

A_23_P145408

A_33_P3272580

GE56083

GO:0003824

GO:0004560

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0005788

GO:0005975

GO:0006004

GO:0009617

GO:0015928

GO:0016139

GO:0016787

GO:0016798

GO:0035578

GO:0043226

GO:0070062

GO:1901135

GO:2000535

HMNXSV003007260

ILMN_1744914

ILMN_2085362

PH_hs_0028786

TC06002187.hg

g13111747_3p_at

Participates

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

FUCA2 [extracellular region]

FUCA2 [azurophil granule lumen]

p-FUCA2 [endoplasmic reticulum lumen]

Inferred To

Fuca2 [endoplasmic reticulum lumen] (Mus musculus)

Fuca2 [endoplasmic reticulum lumen] (Rattus norvegicus)

FUCA2 [endoplasmic reticulum lumen] (Bos taurus)

FUCA2 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

FUCA2 [endoplasmic reticulum lumen] (Canis familiaris)

FUCA2 [endoplasmic reticulum lumen] (Gallus gallus)

FUCA2 [endoplasmic reticulum lumen] (Sus scrofa)

Fuca [endoplasmic reticulum lumen] (Drosophila melanogaster)

fuca2 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_114409.2

ENSEMBL

ENST00000002165, ENSP00000002165

OpenTargets

ENSG00000001036

IntEnz

3.2.1.51

HPA

ENSG00000001036-FUCA2

ZINC - Substances

FUCO2_HUMAN

ZINC target

Q9BTY2

PRO

Q9BTY2

Pharos - Targets

Q9BTY2

ZINC - Predictions - Purchasable

FUCO2_HUMAN

HMDB Protein

HMDBP00876

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.643	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:O96014 WNT11	9	N4GlycoAsn-PalmS WNT11 [extracellular region] (R-HSA-3247797) N4GlycoAsn-PalmS WNT11 [plasma membrane] (R-HSA-3247792) N4GlycoAsn-PalmS WNT11 [Golgi lumen] (R-HSA-3247823) N4GlycoAsn-PalmS WNT11 [endoplasmic reticulum lumen] (R-HSA-3238335) N4GlycoAsn-WNT11 [endoplasmic reticulum lumen] (R-HSA-3238222) WNT11 [endoplasmic reticulum lumen] (R-HSA-3238281) N4GlycoAsn-PalmS WNT11 [endocytic vesicle membrane] (R-HSA-3781987) N4GlycoAsn-PalmS WNT11 [extracellular exosome] (R-HSA-3781980) WNT11 [extracellular region] (R-HSA-517473)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	2

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