Reactome | IL6 [endoplasmic reticulum lumen]

IL6 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956764

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Interleukin-6, IL6_HUMAN

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P05231 IL6

Gene Names

IL6, IFNB2

Chain

signal peptide:1-29, chain:30-212

Reference Genes

BioGPS Gene:3569 IL6

COSMIC (genes):IL6 IL6

CTD Gene:3569 IL6

dbSNP Gene:3569 IL6

ENSEMBL:ENSG00000136244 IL6

HGNC:6018 IL6

KEGG:hsa:3569 IL6

Monarch:3569 IL6

NCBI Gene:3569 IL6

OMIM:147620 IL6

UCSC:P05231 IL6

Reference Transcript

Other Identifiers

11746463_a_at

11760425_a_at

17044177

205207_PM_at

205207_at

2992587

2992588

2992592

2992593

2992594

2992595

2992596

2992597

2992598

2992599

2992600

2992601

2992602

3569

38299_at

8131803

A_14_P133151

A_23_P71037

A_33_P3407013

GE59660

GE84455

GO:0001781

GO:0002314

GO:0002376

GO:0002384

GO:0002446

GO:0002548

GO:0002639

GO:0002675

GO:0002690

GO:0005102

GO:0005125

GO:0005138

GO:0005515

GO:0005576

GO:0005615

GO:0005788

GO:0005896

GO:0006355

GO:0006953

GO:0006954

GO:0006955

GO:0006959

GO:0007165

GO:0008083

GO:0008284

GO:0008285

GO:0010573

GO:0010574

GO:0010575

GO:0010628

GO:0010718

GO:0010888

GO:0012501

GO:0014823

GO:0019221

GO:0030154

GO:0030168

GO:0031018

GO:0031175

GO:0032494

GO:0032682

GO:0032722

GO:0032731

GO:0032733

GO:0032740

GO:0032745

GO:0032755

GO:0032757

GO:0032760

GO:0032966

GO:0033138

GO:0035633

GO:0042102

GO:0042531

GO:0042593

GO:0042802

GO:0043065

GO:0043066

GO:0043410

GO:0045599

GO:0045669

GO:0045727

GO:0045765

GO:0045779

GO:0045893

GO:0045944

GO:0046427

GO:0048018

GO:0048661

GO:0048856

GO:0048870

GO:0050731

GO:0050768

GO:0050796

GO:0050829

GO:0050830

GO:0050871

GO:0051091

GO:0051240

GO:0051384

GO:0051607

GO:0060252

GO:0061470

GO:0061888

GO:0070050

GO:0070091

GO:0070092

GO:0070102

GO:0070301

GO:0071222

GO:0072540

GO:0072574

GO:0090091

GO:0090594

GO:0097421

GO:0097696

GO:0098542

GO:0098586

GO:0098772

GO:0150077

GO:0150078

GO:1900017

GO:1901731

GO:1902512

GO:1903978

GO:1904894

GO:1904996

GO:2000553

GO:2000635

GO:2000660

GO:2000676

HMNXSV003052866

HMNXSV003058441

ILMN_1699651

PH_hs_0026738

TC07000137.hg

X04602_s_at

Y00081_s_at

g10834983_3p_at

Participates

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

IL6 [extracellular region]

p-IL6 [endoplasmic reticulum lumen]

Inferred To

Il6 [endoplasmic reticulum lumen] (Mus musculus)

Il6 [endoplasmic reticulum lumen] (Rattus norvegicus)

IL6 [endoplasmic reticulum lumen] (Bos taurus)

IL6 [endoplasmic reticulum lumen] (Canis familiaris)

IL6 [endoplasmic reticulum lumen] (Gallus gallus)

IL6 [endoplasmic reticulum lumen] (Sus scrofa)

il6 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Cross References

RefSeq

XP_011513692.1, NP_000591.1

OpenTargets

ENSG00000136244

ENSEMBL

ENSP00000385675, ENST00000404625, ENSG00000136244, ENSP00000258743, ENST00000258743

HPA

ENSG00000136244-IL6

GeneCards

IL6

PRO

P05231

Pharos - Targets

P05231

Orphanet

IL6

GlyGen

P05231

PDB

8QY5, 8QY6, 4J4L, 1ALU, 7NXZ, 4NI7, 1IL6, 2IL6, 5FUC, 4CNI, 8D82, 1P9M, 4NI9, 4O9H, 4ZS7

HMDB Protein

HMDBP02087

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08887 IL6R	1	IL6R [plasma membrane] (R-HSA-197824)	0.823	7
UniProt:P40189 IL6ST	2	IL6ST [plasma membrane] (R-HSA-448453) p-Y-IL6ST [plasma membrane] (R-HSA-8950439)	0.667	3
UniProt:P08887-PRO_0000450730 IL6R			0.602	3
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.571	4
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.571	4
UniProt:P05231 IL6	3	IL6 [extracellular region] (R-HSA-447100) IL6 [endoplasmic reticulum lumen] (R-HSA-8956764) p-IL6 [endoplasmic reticulum lumen] (R-HSA-8957044)	0.558	2
UniProt:Q05516 ZBTB16	1	ZBTB16 [cytosol] (R-HSA-976047)	0.519	2