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ADAM10 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8956768
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Disintegrin and metalloproteinase domain-containing protein 10, ADA10_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
ADAM10:Zn2+ binds TSPANs (Homo sapiens)
ADAM10:Zn2+ [endoplasmic reticulum lumen] (Homo sapiens)
ADAM10 [endoplasmic reticulum lumen] (Homo sapiens)
ADAM10:Zn2+:TSPANs [endoplasmic reticulum lumen] (Homo sapiens)
ADAM10:Zn2+ [endoplasmic reticulum lumen] (Homo sapiens)
ADAM10 [endoplasmic reticulum lumen] (Homo sapiens)
ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane (Homo sapiens)
ADAM10:Zn2+:TSPANs [endoplasmic reticulum lumen] (Homo sapiens)
ADAM10:Zn2+ [endoplasmic reticulum lumen] (Homo sapiens)
ADAM10 [endoplasmic reticulum lumen] (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
ADAM10 [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
ADAM10 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14672 ADAM10
Gene Names
ADAM10, KUZ, MADM
Chain
signal peptide:1-19, propeptide:20-213, chain:214-748
Reference Genes
BioGPS Gene:102 ADAM10
COSMIC (genes):ADAM10 ADAM10
CTD Gene:102 ADAM10
dbSNP Gene:102 ADAM10
ENSEMBL:ENSG00000137845 ADAM10
HGNC:188 ADAM10
KEGG:hsa:102 ADAM10
Monarch:102 ADAM10
NCBI Gene:102 ADAM10
OMIM:602192 ADAM10
UCSC:O14672 ADAM10
Reference Transcript
RefSeq:NM_001110.3 ADAM10
Other Identifiers
102
11736026_at
11736027_a_at
11736028_x_at
11751180_a_at
16809880
202603_PM_at
202603_at
202604_PM_x_at
202604_x_at
214895_PM_s_at
214895_s_at
31934_at
3626560
3626561
3626562
3626563
3626564
3626565
3626566
3626567
3626568
3626569
3626570
3626571
3626572
3626574
3626578
3626579
3626580
3626581
3626582
3626583
3626584
3626585
3626587
3626588
3626589
3626590
3626592
3626593
3626595
3626596
3626600
3626601
3626602
3626607
3626608
3626613
3626614
3626615
3626635
3626640
3626641
3626642
3626643
3626644
3626645
3626646
3626647
3626648
3626649
3626650
3626651
3626653
3626654
3626655
40797_at
40798_s_at
58036_at
68865_r_at
7989224
A_23_P48886
A_33_P3243857
GE54099
GE60416
GE773164
GO:0000139
GO:0001701
GO:0002376
GO:0003824
GO:0004175
GO:0004222
GO:0005102
GO:0005178
GO:0005515
GO:0005634
GO:0005737
GO:0005788
GO:0005794
GO:0005798
GO:0005886
GO:0005912
GO:0005925
GO:0006468
GO:0006508
GO:0006509
GO:0007162
GO:0007219
GO:0007229
GO:0007267
GO:0008237
GO:0008284
GO:0008593
GO:0009986
GO:0010629
GO:0010820
GO:0014069
GO:0016020
GO:0016485
GO:0016787
GO:0017124
GO:0019901
GO:0022617
GO:0023052
GO:0030136
GO:0030163
GO:0030198
GO:0030307
GO:0030335
GO:0030424
GO:0030425
GO:0031410
GO:0034330
GO:0034332
GO:0034612
GO:0035579
GO:0038004
GO:0042117
GO:0042803
GO:0042987
GO:0042995
GO:0043226
GO:0043231
GO:0046872
GO:0046930
GO:0046931
GO:0048856
GO:0051089
GO:0051128
GO:0051604
GO:0065003
GO:0070062
GO:0070161
GO:0070573
GO:0070821
GO:0090102
GO:0097038
GO:0097060
GO:0097197
GO:0098696
GO:0098978
GO:0099173
GO:0099175
GO:0140096
GO:0140249
GO:0140448
GO:1901342
GO:1902945
HMNXSV003010919
Hs.172028.0.A2_3p_at
ILMN_1718946
ILMN_2148360
PH_hs_0010303
TC15001484.hg
Z48579_at
g4557250_3p_a_at
Participates
as a component of
ADAM10:Zn2+ [endoplasmic reticulum lumen] (Homo sapiens)
as a member of
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
ADAM10(215-824) [plasma membrane]
ADAM10 [plasma membrane]
p-ADAM10 [endoplasmic reticulum lumen]
ADAM10 [specific granule membrane]
ADAM10 [tertiary granule membrane]
Inferred To
ADAM10 [endoplasmic reticulum lumen]
(Bos taurus)
ADAM10 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
ADAM10 [endoplasmic reticulum lumen]
(Canis familiaris)
ADAM10 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
ADAM10 [endoplasmic reticulum lumen]
(Gallus gallus)
ADAM10 [endoplasmic reticulum lumen]
(Mus musculus)
ADAM10 [endoplasmic reticulum lumen]
(Rattus norvegicus)
ADAM10 [endoplasmic reticulum lumen]
(Sus scrofa)
ADAM10 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001101.1
Guide to Pharmacology - Targets
1658
OpenTargets
ENSG00000137845
ENSEMBL
ENSP00000260408
,
ENST00000260408
ZINC - Substances
ADA10_HUMAN
ZINC target
O14672
PRO
O14672
GlyGen
O14672
PDB
8ESV
,
6BDZ
,
6BE6
HPA
ENSG00000137845-ADAM10
Pharos - Targets
O14672
Orphanet
ADAM10
ZINC - Predictions - Purchasable
ADA10_HUMAN
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95858 TSPAN15
2
TSPAN15 [plasma membrane]
(R-HSA-9010043)
TSPAN15 [endoplasmic reticulum lumen]
(R-HSA-9010117)
0.799
11
UniProt:P62079 TSPAN5
2
TSPAN5 [plasma membrane]
(R-HSA-9010031)
TSPAN5 [endoplasmic reticulum lumen]
(R-HSA-9010081)
0.799
12
UniProt:P21926 CD9
4
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.752
17
UniProt:P60033 CD81
1
CD81 [plasma membrane]
(R-HSA-197933)
0.744
9
UniProt:Q8NG11 TSPAN14
4
TSPAN14 [endoplasmic reticulum lumen]
(R-HSA-9010066)
TSPAN14 [tertiary granule membrane]
(R-HSA-6800899)
TSPAN14 [plasma membrane]
(R-HSA-6800467)
TSPAN14 [specific granule membrane]
(R-HSA-6799708)
0.742
9
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.659
7
UniProt:Q86UF1 TSPAN33
2
TSPAN33 [plasma membrane]
(R-HSA-9010024)
TSPAN33 [endoplasmic reticulum lumen]
(R-HSA-9010054)
0.621
3
UniProt:P06239 LCK
4
LCK [cytosol]
(R-HSA-167609)
p-Y394-LCK [cytosol]
(R-HSA-202308)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
0.602
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.602
5
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.544
3
UniProt:Q9UKS6 PACSIN3
1
PACSIN3 [cytosol]
(R-HSA-8868270)
0.544
3
UniProt:Q96RF0 SNX18
1
SNX18 [cytosol]
(R-HSA-8868038)
0.544
2
UniProt:P12931 SRC
6
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
0.544
3
UniProt:Q99961 SH3GL1
1
SH3GL1 [cytosol]
(R-HSA-8867732)
0.544
2
UniProt:P00519 ABL1
6
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
0.544
2
UniProt:P48509 CD151
2
CD151 [cytosol]
(R-HSA-446072)
CD151 [plasma membrane]
(R-HSA-913947)
0.527
6
UniProt:Q9P2B2 FPRP
0.527
4
UniProt:O95859 TSN12
0.499
2
UniProt:P56817 BACE1
8
BACE1 [endoplasmic reticulum lumen]
(R-HSA-6783326)
7K-BACE1 [endoplasmic reticulum lumen]
(R-HSA-5693006)
BACE1(22-45) [Golgi-associated vesicle lumen]
(R-HSA-5693069)
7K-BACE1 [Golgi-associated vesicle lumen]
(R-HSA-5693095)
7K-BACE1(46-501) [Golgi-associated vesicle lumen]
(R-HSA-5693106)
BACE1(46-501) [Golgi-associated vesicle lumen]
(R-HSA-5693105)
BACE1(46-501) [plasma membrane]
(R-HSA-5692933)
BACE1 [endosome membrane]
(R-HSA-5692942)
0.454
3
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