Reactome | p-MEN1 [endoplasmic reticulum lumen]

p-MEN1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956901

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

MEN1, Menin, MEN1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00255 MEN1

Gene Names

MEN1, SCG2

Chain

chain:1-610

Reference Genes

BioGPS Gene:4221 MEN1

COSMIC (genes):MEN1 MEN1

COSMIC (genes):SCG2 MEN1

CTD Gene:4221 MEN1

dbSNP Gene:4221 MEN1

ENSEMBL:ENSG00000133895 MEN1

HGNC:7010 MEN1

KEGG:hsa:4221 MEN1

Monarch:4221 MEN1

NCBI Gene:4221 MEN1

OMIM:613733 MEN1

UCSC:O00255 MEN1

Reference Transcript

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

MEN1 [nucleoplasm]

MEN1 [endoplasmic reticulum lumen]

MEN1 [cytosol]

Inferred To

phospho-MEN1 [endoplasmic reticulum lumen] (Bos taurus)

phospho-MEN1 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-MEN1 [endoplasmic reticulum lumen] (Sus scrofa)

phospho-Mnn1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

phospho-Men1 [endoplasmic reticulum lumen] (Mus musculus)

phospho-Men1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_570715.1, NP_570712.1, XP_005274058.1, XP_016873259.1, NP_570713.1, XP_016873258.1, NP_000235.2, NP_570711.1, NP_570714.1, NP_570716.1

OpenTargets

ENSG00000133895

ENSEMBL

ENST00000440873, ENSP00000518530, ENST00000424912, ENSG00000133895, ENSP00000388016, ENST00000377326, ENST00000377313, ENST00000710881, ENST00000413626, ENSP00000402752, ENST00000429702, ENSP00000394933, ENSP00000413944, ENSP00000411218, ENSP00000366530, ENSP00000366543, ENSP00000308975, ENST00000450708, ENST00000315422, ENSP00000323747, ENST00000312049

HPA

ENSG00000133895-MEN1

GeneCards

MEN1

ZINC - Substances

MEN1_HUMAN

ZINC target

O00255

PRO

O00255

Pharos - Targets

O00255

Orphanet

MEN1

ZINC - Predictions - Purchasable

MEN1_HUMAN

PDB

8IG0, 6BXY, 4GQ6, 6BY8, 6OPJ, 4I80, 4GPQ, 7M4T, 4GQ3, 6O5I, 6WNH, 4GQ4, 5DB0, 5DB1, 5DB2, 4X5Z, 7O9Z, 7UJ4, 4OG5, 5DDE, 5DDF, 4OG6, 5DB3, 8E90, 5DD9, 6BXH, 6PKC, 4OG7, 7O9T, 5DDA, 5DDB, 3U86, 6S2K, 4OG3, 7O9X, 4OG8, 3U84, 3U85, 5DDC, 5DDD, 7OA9, 6E1A, 6B41, 3U88, 4OG4, 4X5Y, 8GPN

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.708	4
UniProt:Q03164 KMT2A	6	KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A [cytosol] (R-HSA-9818584)	0.643	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.556	3
UniProt:P19838-PRO_0000030311 NFKB1			0.524	2
UniProt:Q9BXW9 FANCD2	3	FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481)	0.524	4
UniProt:Q9UMN6 KMT2B	5	KMT2B [cytosol] (R-HSA-9818624) KMT2B(2-2062) [cytosol] (R-HSA-9818621) KMT2B(2063-2715) [cytosol] (R-HSA-9818626) KMT2B(2063-2715) [nucleoplasm] (R-HSA-9818623) KMT2B(2-2062) [nucleoplasm] (R-HSA-9818620)	0.462	2

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