Reactome | p-MEN1 [endoplasmic reticulum lumen]

p-MEN1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956901

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

MEN1, Menin, MEN1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O00255 MEN1

Gene Names

MEN1, SCG2

Chain

chain:1-610

Reference Genes

BioGPS Gene:4221 MEN1

COSMIC (genes):MEN1 MEN1

COSMIC (genes):SCG2 MEN1

CTD Gene:4221 MEN1

dbSNP Gene:4221 MEN1

ENSEMBL:ENSG00000133895 MEN1

HGNC:7010 MEN1

KEGG:hsa:4221 MEN1

Monarch:4221 MEN1

NCBI Gene:4221 MEN1

OMIM:613733 MEN1

UCSC:O00255 MEN1

Reference Transcript

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

MEN1 [nucleoplasm]

MEN1 [cytosol]

MEN1 [endoplasmic reticulum lumen]

Inferred To

phospho-MEN1 [endoplasmic reticulum lumen] (Bos taurus)

phospho-MEN1 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-MEN1 [endoplasmic reticulum lumen] (Sus scrofa)

phospho-Mnn1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

phospho-Men1 [endoplasmic reticulum lumen] (Mus musculus)

phospho-Men1 [endoplasmic reticulum lumen] (Rattus norvegicus)

phospho-men1 [endoplasmic reticulum lumen] (Danio rerio)

phospho-men1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

XP_016873259.1, XP_016873258.1, NP_570712.2, XP_005274058.1, NP_570711.2, NP_001394076.1, NP_570714.2, NP_001394074.1, NP_001394075.1, NP_570716.2, NP_570713.2, NP_570715.2, NP_000235.2, NP_001357190.2, NP_001357189.2, NP_001357188.2

OpenTargets

ENSG00000133895

ENSEMBL

ENST00000312049, ENSP00000308975, ENST00000440873, ENST00000424912, ENSP00000413944, ENSP00000411218, ENST00000450708, ENST00000315422, ENST00000710881, ENSP00000518530, ENSG00000133895, ENSP00000402752, ENSP00000366543, ENST00000429702, ENSP00000366530, ENSP00000388016, ENST00000377326, ENST00000377313, ENSP00000394933, ENST00000413626, ENSP00000323747

HPA

ENSG00000133895-MEN1

GeneCards

MEN1

ZINC - Substances

MEN1_HUMAN

ZINC target

O00255

PRO

O00255

Pharos - Targets

O00255

Orphanet

MEN1

ZINC - Predictions - Purchasable

MEN1_HUMAN

PDB

7M4T, 5DDB, 8IG0, 5DDD, 5DD9, 4X5Y, 6OPJ, 5DDE, 6BXY, 4GQ3, 4I80, 9C93, 5DB2, 3U85, 6B41, 4OG6, 4OG7, 6PKC, 7O9T, 6WNH, 4OG4, 5DB3, 6E1A, 7O9Z, 3U86, 5DDA, 6S2K, 5DDC, 3U88, 5DB0, 8E90, 4X5Z, 5DDF, 7OA9, 6BY8, 9C94, 4GQ6, 6O5I, 4GPQ, 3U84, 9C92, 5DB1, 7UJ4, 8VA6, 4OG5, 4OG3, 8VA5, 4GQ4, 4OG8, 8GPN, 7O9X, 6BXH

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.708	4
UniProt:Q03164 KMT2A	6	KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A [cytosol] (R-HSA-9818584)	0.643	3
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.596	4
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.556	3
UniProt:Q15762 CD226	1	CD226 [plasma membrane] (R-HSA-197562)	0.527	2
UniProt:Q9BXW9 FANCD2	3	FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481)	0.524	4
UniProt:P19838-PRO_0000030311 NFKB1			0.524	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.483	2
UniProt:Q9UMN6 KMT2B	5	KMT2B [cytosol] (R-HSA-9818624) KMT2B(2-2062) [cytosol] (R-HSA-9818621) KMT2B(2063-2715) [cytosol] (R-HSA-9818626) KMT2B(2063-2715) [nucleoplasm] (R-HSA-9818623) KMT2B(2-2062) [nucleoplasm] (R-HSA-9818620)	0.462	2

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