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p-P4HB [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8956902
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
P4HB, PDI, Protein disulfide isomerase
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
p-P4HB [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
p-P4HB [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07237 P4HB
Gene Names
P4HB, ERBA2L, PDI, PDIA1, PO4DB
Chain
signal peptide:1-17, chain:18-508
Reference Genes
BioGPS Gene:5034 P4HB
COSMIC (genes):P4HB P4HB
CTD Gene:5034 P4HB
dbSNP Gene:5034 P4HB
ENSEMBL:ENSG00000185624 P4HB
HGNC:8548 P4HB
KEGG Gene (Homo sapiens):5034 P4HB
Monarch:5034 P4HB
NCBI Gene:5034 P4HB
OMIM:176790 P4HB
UCSC:P07237 P4HB
Reference Transcript
RefSeq:NM_000918.3 P4HB
Other Identifiers
0005890736
11716173_a_at
11716174_s_at
11716175_x_at
11752448_a_at
11752449_x_at
11752645_a_at
1564494_s_at
200654_at
200656_s_at
36666_at
3774242
3774243
3774244
3774245
3774246
3774247
3774250
3774251
3774252
3774256
3774258
3774259
3774260
3774261
3774262
3774263
3774268
3774270
3774276
3774281
3774282
4041341
4041343
4041344
4041345
4041346
4041347
4041348
4041349
4041350
4041351
4041355
4041358
4041359
4041360
4041361
4041362
4041367
4041368
4041369
4041373
4041374
4041376
4041377
5034
691_g_at
8019250
8019762
A_23_P107412
A_33_P3252043
GE80965
GO:0000902
GO:0003674
GO:0003723
GO:0003756
GO:0003779
GO:0004656
GO:0005178
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005793
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006457
GO:0006464
GO:0006950
GO:0007155
GO:0007165
GO:0008092
GO:0008150
GO:0008219
GO:0009897
GO:0015037
GO:0016020
GO:0016222
GO:0016491
GO:0016853
GO:0016972
GO:0018215
GO:0018401
GO:0019899
GO:0022607
GO:0030027
GO:0030154
GO:0030198
GO:0030199
GO:0031410
GO:0032991
GO:0034378
GO:0034379
GO:0034663
GO:0034975
GO:0034976
GO:0035722
GO:0038155
GO:0042470
GO:0043226
GO:0043687
GO:0044267
GO:0044403
GO:0044877
GO:0045785
GO:0046598
GO:0046982
GO:0048856
GO:0051213
GO:0065003
GO:0070062
GO:0071456
GO:0098761
GO:1900026
GO:1902175
HMNXSV003029683
Hs2.397055.1.S1_3p_s_at
ILMN_1719303
J02783_at
PH_hs_0019534
TC17001960.hg
X05130_s_at
g4505566_3p_a_at
Participates
as a member of
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
P4HB [endoplasmic reticulum lumen]
HC53,56-P4HB [endoplasmic reticulum lumen]
Inferred To
phospho-Pdi [endoplasmic reticulum lumen]
(Drosophila melanogaster)
phospho-P4HB [endoplasmic reticulum lumen]
(Canis familiaris)
phospho-P4HB [endoplasmic reticulum lumen]
(Sus scrofa)
phospho-P4hb [endoplasmic reticulum lumen]
(Mus musculus)
phospho-P4hb [endoplasmic reticulum lumen]
(Rattus norvegicus)
phospho-p4hb [endoplasmic reticulum lumen]
(Danio rerio)
phospho-p4hb [endoplasmic reticulum lumen]
(Xenopus tropicalis)
phospho-pdi-2 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_000909.2
OpenTargets
ENSG00000185624
IntEnz
5.3.4.1
GeneCards
P07237
HPA
ENSG00000185624-P4HB
Ensembl
ENSG00000185624
,
ENSP00000327801
,
ENST00000331483
PRO
P07237
Pharos - Targets
P07237
Orphanet
23211
GlyGen
P07237
HMDB Protein
HMDBP02802
PDB
1MEK
,
2BJX
,
4EKZ
,
1BJX
,
4JU5
,
1X5C
,
2K18
,
4EL1
,
6I7S
,
3UEM
,
3BJ5
Interactors (56)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.666
4
UniProt:Q96HE7 ERO1A
1
ERO1L [endoplasmic reticulum lumen]
(R-HSA-265076)
0.656
3
UniProt:Q8TDX7 NEK7
2
p-S195-NEK7 [cytosol]
(R-HSA-2984246)
NEK7 [cytosol]
(R-HSA-2530599)
0.638
3
UniProt:P02452 COL1A1
20
3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023648)
3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023667)
GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023604)
GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022999)
3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023559)
3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023582)
COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1650777)
3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985659)
3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022446)
3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022951)
3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022954)
5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985663)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396137)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396440)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396471)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396464)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396068)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396388)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396315)
Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396441)
0.576
3
ChEBI:28304 HEPARIN
0.57
3
UniProt:P60520 GABARAPL2
3
GABARAPL2 [cytosol]
(R-HSA-5671758)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
0.564
2
UniProt:Q5T0J7-2 TEX35
0.556
3
UniProt:Q8NEG0 FA71C
0.556
3
UniProt:Q14990 ODFP1
0.556
3
UniProt:P17655 CAPN2
2
CAPN2 [cytosol]
(R-HSA-8848630)
CAPN2 [plasma membrane]
(R-HSA-8863405)
0.556
3
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:Q86WV1-2 SKAP1
0.556
3
UniProt:Q5TA82 LCE2D
1
LCE2D [cytosol]
(R-HSA-6814300)
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:P09228 CYTT
0.556
3
UniProt:P60328 KRTAP12-3
1
KRTAP12-3 [cytosol]
(R-HSA-6810284)
0.556
3
UniProt:Q92692-2 NECTIN2
0.556
3
UniProt:Q494V2-2 CFAP100
0.556
3
UniProt:Q8TAB7 CCD26
0.556
3
UniProt:O00444 PLK4
1
PLK4 [cytosol]
(R-HSA-380286)
0.556
3
UniProt:P80188 LCN2
2
LCN2 [specific granule lumen]
(R-HSA-6799614)
LCN2 [extracellular region]
(R-HSA-5215934)
0.556
3
UniProt:Q9P121-3 NTM
0.556
3
UniProt:Q5T7P3 LCE1B
1
LCE1B [cytosol]
(R-HSA-6814271)
0.556
3
UniProt:Q5TA78 LCE4A
1
LCE4A [cytosol]
(R-HSA-6814272)
0.556
3
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.556
3
UniProt:Q52LG2 KRTAP13-2
1
KRTAP13-2 [cytosol]
(R-HSA-6810274)
0.556
3
UniProt:Q9ULW2 FZD10
1
FZD10 [plasma membrane]
(R-HSA-443943)
0.556
3
UniProt:Q9UC07-2 ZNF69
0.556
3
UniProt:O94818-2 NOL4
0.556
3
UniProt:Q8NE01 CNNM3
0.556
3
UniProt:Q9NU02 ANKE1
0.556
3
UniProt:Q53R41 FAKD1
0.556
3
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.556
3
UniProt:Q8TAP6 CEP76
1
CEP76 [cytosol]
(R-HSA-380281)
0.556
3
UniProt:P02538 KRT6A
1
KRT6A [cytosol]
(R-HSA-6809654)
0.556
3
UniProt:Q8N4N3-2 KLHL36
0.556
3
UniProt:Q9P2K6 KLHL42
1
KLHL42 [cytosol]
(R-HSA-8863204)
0.556
3
UniProt:P62873 GNB1
5
GNB1 [photoreceptor disc membrane]
(R-HSA-55373)
Unfolded GNB1 [cytosol]
(R-HSA-6814200)
Partially folded GNB1 [cytosol]
(R-HSA-8850526)
GNB1 [plasma membrane]
(R-HSA-164347)
GNB1 [cytosol]
(R-HSA-6814412)
0.556
3
UniProt:Q63HM9 PLCX3
0.556
3
UniProt:Q9Y6H1 CHCHD2
2
2xHC-CHCHD2 [mitochondrial intermembrane space]
(R-HSA-6800100)
CHCHD2 [mitochondrial intermembrane space]
(R-HSA-1307777)
0.556
3
UniProt:P01137 TGFB1
7
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [Golgi lumen]
(R-HSA-9736812)
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.556
3
UniProt:O43521 BCL2L11
7
BCL2L11 [mitochondrial outer membrane]
(R-HSA-2976674)
BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]
(R-HSA-6802276)
BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]
(R-HSA-6802519)
p-S65-BCL2L11 [cytosol]
(R-HSA-2976671)
p-BCL2L11 [mitochondrial outer membrane]
(R-HSA-3145027)
p-BCL2L11 [cytosol]
(R-HSA-140525)
BCL2L11 [cytosol]
(R-HSA-2976673)
0.556
3
UniProt:Q9BYQ0 KRTAP9-8
1
KRTAP9-8 [cytosol]
(R-HSA-6809953)
0.556
3
UniProt:Q9BYQ6 KRTAP4-11
1
KRTAP4-11 [cytosol]
(R-HSA-6809960)
0.556
3
IntAct:EBI-22311199 CCSB ORF ID
0.556
3
UniProt:Q8WUG5 SLC22A17
1
SLC22A17 [plasma membrane]
(R-HSA-561099)
0.556
3
IntAct:EBI-25846222 CCSB
0.556
3
UniProt:Q96RK4 BBS4
1
BBS4 [cytosol]
(R-HSA-5617635)
0.556
3
UniProt:O15534 PER1
4
p-S-PER1 [cytosol]
(R-HSA-400310)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
PER1 [cytosol]
(R-HSA-400373)
Ub-p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:Q6PJG9 LRFN4
1
SALM3 [plasma membrane]
(R-HSA-197883)
0.556
3
UniProt:O15460 P4HA2
1
P4HA2 [endoplasmic reticulum lumen]
(R-HSA-2980974)
0.534
2
UniProt:Q9UBS9 SUCO
0.527
2
UniProt:Q2GL86 Q2GL86
0.508
3
UniProt:Q03518 TAP1
3
TAP1 [phagocytic vesicle membrane]
(R-HSA-1236845)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863953)
TAP1 [endoplasmic reticulum membrane]
(R-HSA-947474)
0.499
4
UniProt:P10636 MAPT
3
MAPT(422-758) [cytosol]
(R-HSA-350642)
MAPT(2-421) [cytosol]
(R-HSA-350628)
MAPT [cytosol]
(R-HSA-201574)
0.463
2
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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