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p-P4HB [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8956902
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
P4HB, PDI, Protein disulfide isomerase
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
p-P4HB [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
p-P4HB [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07237 P4HB
Gene Names
P4HB, ERBA2L, PDI, PDIA1, PO4DB
Chain
signal peptide:1-17, chain:18-508
Reference Genes
BioGPS Gene:5034 P4HB
COSMIC (genes):P4HB P4HB
CTD Gene:5034 P4HB
dbSNP Gene:5034 P4HB
ENSEMBL:ENSG00000185624 P4HB
HGNC:8548 P4HB
KEGG:hsa:5034 P4HB
Monarch:5034 P4HB
NCBI Gene:5034 P4HB
OMIM:176790 P4HB
UCSC:P07237 P4HB
Reference Transcript
RefSeq:NM_000918.3 P4HB
Other Identifiers
11716173_a_at
11716174_s_at
11716175_x_at
11752448_a_at
11752449_x_at
11752645_a_at
1564494_PM_s_at
1564494_s_at
16849939
200654_PM_at
200654_at
200656_PM_s_at
200656_s_at
3275276
36666_at
3774233
3774234
3774235
3774236
3774237
3774238
3774239
3774240
3774242
3774243
3774244
3774245
3774246
3774247
3774248
3774249
3774250
3774251
3774252
3774253
3774254
3774255
3774256
3774257
3774258
3774259
3774260
3774261
3774262
3774263
3774264
3774266
3774267
3774268
3774269
3774270
3774271
3774272
3774273
3774274
3774275
3774276
3774277
3774278
3774279
3774280
3774281
3774282
3774284
3774285
4041334
4041336
4041338
4041339
4041341
4041343
4041344
4041345
4041346
4041347
4041348
4041349
4041350
4041351
4041352
4041353
4041354
4041355
4041356
4041357
4041358
4041359
4041360
4041361
4041362
4041363
4041366
4041367
4041368
4041369
4041370
4041371
4041372
4041373
4041374
4041375
4041376
4041377
4041379
5034
691_g_at
7893598
7895969
8019250
8019762
A_23_P107412
A_33_P3252043
GE80965
GO:0003723
GO:0003756
GO:0003779
GO:0003824
GO:0004656
GO:0005178
GO:0005515
GO:0005576
GO:0005783
GO:0005788
GO:0005793
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006457
GO:0006520
GO:0006575
GO:0006888
GO:0008092
GO:0009897
GO:0015035
GO:0016192
GO:0016222
GO:0016491
GO:0016853
GO:0016972
GO:0018401
GO:0019899
GO:0030027
GO:0030070
GO:0031410
GO:0032991
GO:0034663
GO:0034975
GO:0034976
GO:0035722
GO:0038155
GO:0042470
GO:0043226
GO:0044877
GO:0045785
GO:0046598
GO:0046982
GO:0051213
GO:0051604
GO:0070062
GO:0071456
GO:0098761
GO:0140096
GO:1900026
GO:1902175
GO:2000406
HMNXSV003029683
Hs2.397055.1.S1_3p_s_at
ILMN_1719303
J02783_at
PH_hs_0019534
TC17001960.hg
X05130_s_at
g4505566_3p_a_at
Participates
as a member of
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
P4HB [endoplasmic reticulum lumen]
HC53,56-P4HB [endoplasmic reticulum lumen]
Inferred To
phospho-Pdi [endoplasmic reticulum lumen]
(Drosophila melanogaster)
phospho-P4HB [endoplasmic reticulum lumen]
(Bos taurus)
phospho-P4HB [endoplasmic reticulum lumen]
(Sus scrofa)
phospho-P4hb [endoplasmic reticulum lumen]
(Mus musculus)
phospho-P4hb [endoplasmic reticulum lumen]
(Rattus norvegicus)
phospho-p4hb [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Homologues of p-P4HB [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
phospho-pdi-1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
phospho-p-P4HB [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
phospho-p-P4HB [endoplasmic reticulum lumen]
(Canis familiaris)
phospho-p-P4HB [endoplasmic reticulum lumen]
(Gallus gallus)
phospho-pdi-2 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_000909.2
OpenTargets
ENSG00000185624
ENSEMBL
ENSG00000185624
,
ENST00000331483
,
ENSP00000327801
GeneCards
P4HB
HPA
ENSG00000185624-P4HB
PRO
P07237
Pharos - Targets
P07237
GlyGen
P07237
Orphanet
P4HB
HMDB Protein
HMDBP02802
PDB
1BJX
,
2BJX
,
3BJ5
,
4JU5
,
8GDY
,
4EL1
,
8EOJ
,
1X5C
,
6I7S
,
3UEM
,
4EKZ
,
2K18
,
1MEK
,
7ZSC
Interactors (60)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15460 P4HA2
1
P4HA2 [endoplasmic reticulum lumen]
(R-HSA-2980974)
0.74
5
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.713
6
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.666
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.658
17
UniProt:Q96HE7 ERO1A
1
ERO1L [endoplasmic reticulum lumen]
(R-HSA-265076)
0.656
3
UniProt:Q9UBS9 SUCO
0.643
3
UniProt:Q7Z4N8 P4HA3
1
P4HA3 [endoplasmic reticulum lumen]
(R-HSA-2980915)
0.643
3
UniProt:Q8TDX7 NEK7
2
p-S195-NEK7 [cytosol]
(R-HSA-2984246)
NEK7 [cytosol]
(R-HSA-2530599)
0.638
3
UniProt:P02452 COL1A1
20
3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023648)
3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023667)
GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023604)
GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022999)
3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023559)
3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023582)
COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1650777)
3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985659)
3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022446)
3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022951)
3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022954)
5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985663)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396137)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396440)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396471)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396464)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396068)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396388)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396315)
Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396441)
0.576
3
ChEBI:28304 HEPARIN
0.57
3
UniProt:P60520 GABARAPL2
3
GABARAPL2 [cytosol]
(R-HSA-5671758)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
0.564
2
UniProt:Q5T0J7-2 TEX35
0.556
3
UniProt:Q3LI67 KRTAP6-3
1
KRTAP6-3 [cytosol]
(R-HSA-6810281)
0.556
3
UniProt:Q8NEG0 GAR6
0.556
3
UniProt:P17655 CAPN2
2
CAPN2 [plasma membrane]
(R-HSA-8863405)
CAPN2 [cytosol]
(R-HSA-8848630)
0.556
3
UniProt:Q14990 ODFP1
0.556
3
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:Q86WV1-2 SKAP1
0.556
3
UniProt:Q5TA82 LCE2D
1
LCE2D [cytosol]
(R-HSA-6814300)
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:Q92692-2 NECTIN2
0.556
3
UniProt:P09228 CYTT
0.556
3
UniProt:P60328 KRTAP12-3
1
KRTAP12-3 [cytosol]
(R-HSA-6810284)
0.556
3
UniProt:CCDC26 A0A024R9H7
0.556
3
UniProt:Q494V2-2 CFAP100
0.556
3
UniProt:O00444 PLK4
1
PLK4 [cytosol]
(R-HSA-380286)
0.556
3
UniProt:Q96RK4 BBS4
1
BBS4 [cytosol]
(R-HSA-5617635)
0.556
3
UniProt:O43521 BCL2L11
7
BCL2L11 [cytosol]
(R-HSA-2976673)
p-BCL2L11 [cytosol]
(R-HSA-140525)
p-BCL2L11 [mitochondrial outer membrane]
(R-HSA-3145027)
p-S69-BCL2L11 [cytosol]
(R-HSA-2976671)
BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]
(R-HSA-6802519)
BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]
(R-HSA-6802276)
BCL2L11 [mitochondrial outer membrane]
(R-HSA-2976674)
0.556
3
UniProt:Q8WUG5 SLC22A17
1
SLC22A17 [plasma membrane]
(R-HSA-561099)
0.556
3
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.556
3
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.556
3
UniProt:O15534 PER1
4
PER1 [cytosol]
(R-HSA-400373)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
p-S-PER1 [cytosol]
(R-HSA-400310)
K48polyUb-K,p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:Q6PJG9 LRFN4
1
SALM3 [plasma membrane]
(R-HSA-197883)
0.556
3
IntAct:EBI-25846222 CCSB
0.556
3
UniProt:Q9BYQ6 KRTAP4-11
1
KRTAP4-11 [cytosol]
(R-HSA-6809960)
0.556
3
UniProt:Q9BYQ0 KRTAP9-8
1
KRTAP9-8 [cytosol]
(R-HSA-6809953)
0.556
3
UniProt:P01137 TGFB1
7
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [Golgi lumen]
(R-HSA-9736812)
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.556
3
UniProt:Q9Y6H1 CHCHD2
2
2xHC-CHCHD2 [mitochondrial intermembrane space]
(R-HSA-6800100)
CHCHD2 [mitochondrial intermembrane space]
(R-HSA-1307777)
0.556
3
UniProt:Q63HM9 PLCX3
0.556
3
UniProt:Q9P2K6 KLHL42
1
KLHL42 [cytosol]
(R-HSA-8863204)
0.556
3
UniProt:P62873 GNB1
5
GNB1 [cytosol]
(R-HSA-6814412)
GNB1 [plasma membrane]
(R-HSA-164347)
Unfolded GNB1 [cytosol]
(R-HSA-6814200)
Partially folded GNB1 [cytosol]
(R-HSA-8850526)
GNB1 [photoreceptor disc membrane]
(R-HSA-55373)
0.556
3
UniProt:Q8N4N3-2 KLHL36
0.556
3
UniProt:P02538 KRT6A
1
KRT6A [cytosol]
(R-HSA-6809654)
0.556
3
UniProt:Q8TAP6 CEP76
1
CEP76 [cytosol]
(R-HSA-380281)
0.556
3
UniProt:Q53R41 FAKD1
0.556
3
UniProt:Q9NU02 ANKE1
0.556
3
UniProt:Q8NE01 CNNM3
0.556
3
UniProt:O94818-2 NOL4
0.556
3
UniProt:Q9UC07-2 ZNF69
0.556
3
UniProt:Q9ULW2 FZD10
1
FZD10 [plasma membrane]
(R-HSA-443943)
0.556
3
UniProt:Q52LG2 KRTAP13-2
1
KRTAP13-2 [cytosol]
(R-HSA-6810274)
0.556
3
UniProt:Q5TA78 LCE4A
1
LCE4A [cytosol]
(R-HSA-6814272)
0.556
3
UniProt:Q5T7P3 LCE1B
1
LCE1B [cytosol]
(R-HSA-6814271)
0.556
3
UniProt:Q9P121-3 NTM
0.556
3
UniProt:P80188 LCN2
2
LCN2 [extracellular region]
(R-HSA-5215934)
LCN2 [specific granule lumen]
(R-HSA-6799614)
0.556
3
UniProt:Q8N680 ZBTB2
0.527
2
UniProt:Q2GL86 Q2GL86
0.508
3
UniProt:Q03518 TAP1
3
TAP1 [endoplasmic reticulum membrane]
(R-HSA-947474)
TAP1 [phagocytic vesicle membrane]
(R-HSA-1236845)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863953)
0.499
4
UniProt:P10636 MAPT
3
MAPT [cytosol]
(R-HSA-201574)
MAPT(2-421) [cytosol]
(R-HSA-350628)
MAPT(422-758) [cytosol]
(R-HSA-350642)
0.463
2
UniProt:P04578 env
7
Surface protein gp120 [viral envelope]
(R-HIV-171211)
ENV [viral envelope]
(R-HIV-173439)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
0.462
2
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