Reactome | p-P4HB [endoplasmic reticulum lumen]

p-P4HB [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956902

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

P4HB, PDI, Protein disulfide isomerase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P07237 P4HB

Gene Names

P4HB, ERBA2L, PDI, PDIA1, PO4DB

Chain

signal peptide:1-17, chain:18-508

Reference Genes

BioGPS Gene:5034 P4HB

COSMIC (genes):P4HB P4HB

CTD Gene:5034 P4HB

dbSNP Gene:5034 P4HB

ENSEMBL:ENSG00000185624 P4HB

HGNC:8548 P4HB

KEGG Gene (Homo sapiens):5034 P4HB

Monarch:5034 P4HB

NCBI Gene:5034 P4HB

OMIM:176790 P4HB

UCSC:P07237 P4HB

Reference Transcript

RefSeq:NM_000918.3 P4HB

Other Identifiers

0005890736

11716173_a_at

11716174_s_at

11716175_x_at

11752448_a_at

11752449_x_at

11752645_a_at

1564494_s_at

200654_at

200656_s_at

36666_at

3774242

3774243

3774244

3774245

3774246

3774247

3774250

3774251

3774252

3774256

3774258

3774259

3774260

3774261

3774262

3774263

3774268

3774270

3774276

3774281

3774282

4041341

4041343

4041344

4041345

4041346

4041347

4041348

4041349

4041350

4041351

4041355

4041358

4041359

4041360

4041361

4041362

4041367

4041368

4041369

4041373

4041374

4041376

4041377

5034

691_g_at

8019250

8019762

A_23_P107412

A_33_P3252043

GE80965

GO:0000902

GO:0003674

GO:0003723

GO:0003756

GO:0003779

GO:0004656

GO:0005178

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005793

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006457

GO:0006464

GO:0006950

GO:0007155

GO:0007165

GO:0008092

GO:0008150

GO:0008219

GO:0009897

GO:0015037

GO:0016020

GO:0016222

GO:0016491

GO:0016853

GO:0016972

GO:0018215

GO:0018401

GO:0019899

GO:0022607

GO:0030027

GO:0030154

GO:0030198

GO:0030199

GO:0031410

GO:0032991

GO:0034378

GO:0034379

GO:0034663

GO:0034975

GO:0034976

GO:0035722

GO:0038155

GO:0042470

GO:0043226

GO:0043687

GO:0044267

GO:0044403

GO:0044877

GO:0045785

GO:0046598

GO:0046982

GO:0048856

GO:0051213

GO:0065003

GO:0070062

GO:0071456

GO:0098761

GO:1900026

GO:1902175

HMNXSV003029683

Hs2.397055.1.S1_3p_s_at

ILMN_1719303

J02783_at

PH_hs_0019534

TC17001960.hg

X05130_s_at

g4505566_3p_a_at

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

P4HB [endoplasmic reticulum lumen]

HC53,56-P4HB [endoplasmic reticulum lumen]

Inferred To

phospho-Pdi [endoplasmic reticulum lumen] (Drosophila melanogaster)

phospho-P4HB [endoplasmic reticulum lumen] (Canis familiaris)

phospho-P4HB [endoplasmic reticulum lumen] (Sus scrofa)

phospho-P4hb [endoplasmic reticulum lumen] (Mus musculus)

phospho-P4hb [endoplasmic reticulum lumen] (Rattus norvegicus)

phospho-p4hb [endoplasmic reticulum lumen] (Danio rerio)

phospho-p4hb [endoplasmic reticulum lumen] (Xenopus tropicalis)

phospho-pdi-2 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_000909.2

OpenTargets

ENSG00000185624

IntEnz

5.3.4.1

GeneCards

P07237

HPA

ENSG00000185624-P4HB

Ensembl

ENSG00000185624, ENSP00000327801, ENST00000331483

PRO

P07237

Pharos - Targets

P07237

Orphanet

23211

GlyGen

P07237

HMDB Protein

HMDBP02802

PDB

1MEK, 2BJX, 4EKZ, 1BJX, 4JU5, 1X5C, 2K18, 4EL1, 6I7S, 3UEM, 3BJ5

Interactors (56)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.666	4
UniProt:Q96HE7 ERO1A	1	ERO1L [endoplasmic reticulum lumen] (R-HSA-265076)	0.656	3
UniProt:Q8TDX7 NEK7	2	p-S195-NEK7 [cytosol] (R-HSA-2984246) NEK7 [cytosol] (R-HSA-2530599)	0.638	3
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.576	3
ChEBI:28304 HEPARIN			0.57	3
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.564	2
UniProt:Q5T0J7-2 TEX35			0.556	3
UniProt:Q8NEG0 FA71C			0.556	3
UniProt:Q14990 ODFP1			0.556	3
UniProt:P17655 CAPN2	2	CAPN2 [cytosol] (R-HSA-8848630) CAPN2 [plasma membrane] (R-HSA-8863405)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q86WV1-2 SKAP1			0.556	3
UniProt:Q5TA82 LCE2D	1	LCE2D [cytosol] (R-HSA-6814300)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P09228 CYTT			0.556	3
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:Q92692-2 NECTIN2			0.556	3
UniProt:Q494V2-2 CFAP100			0.556	3
UniProt:Q8TAB7 CCD26			0.556	3
UniProt:O00444 PLK4	1	PLK4 [cytosol] (R-HSA-380286)	0.556	3
UniProt:P80188 LCN2	2	LCN2 [specific granule lumen] (R-HSA-6799614) LCN2 [extracellular region] (R-HSA-5215934)	0.556	3
UniProt:Q9P121-3 NTM			0.556	3
UniProt:Q5T7P3 LCE1B	1	LCE1B [cytosol] (R-HSA-6814271)	0.556	3
UniProt:Q5TA78 LCE4A	1	LCE4A [cytosol] (R-HSA-6814272)	0.556	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.556	3
UniProt:Q52LG2 KRTAP13-2	1	KRTAP13-2 [cytosol] (R-HSA-6810274)	0.556	3
UniProt:Q9ULW2 FZD10	1	FZD10 [plasma membrane] (R-HSA-443943)	0.556	3
UniProt:Q9UC07-2 ZNF69			0.556	3
UniProt:O94818-2 NOL4			0.556	3
UniProt:Q8NE01 CNNM3			0.556	3
UniProt:Q9NU02 ANKE1			0.556	3
UniProt:Q53R41 FAKD1			0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:P02538 KRT6A	1	KRT6A [cytosol] (R-HSA-6809654)	0.556	3
UniProt:Q8N4N3-2 KLHL36			0.556	3
UniProt:Q9P2K6 KLHL42	1	KLHL42 [cytosol] (R-HSA-8863204)	0.556	3
UniProt:P62873 GNB1	5	GNB1 [photoreceptor disc membrane] (R-HSA-55373) Unfolded GNB1 [cytosol] (R-HSA-6814200) Partially folded GNB1 [cytosol] (R-HSA-8850526) GNB1 [plasma membrane] (R-HSA-164347) GNB1 [cytosol] (R-HSA-6814412)	0.556	3
UniProt:Q63HM9 PLCX3			0.556	3
UniProt:Q9Y6H1 CHCHD2	2	2xHC-CHCHD2 [mitochondrial intermembrane space] (R-HSA-6800100) CHCHD2 [mitochondrial intermembrane space] (R-HSA-1307777)	0.556	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.556	3
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-S65-BCL2L11 [cytosol] (R-HSA-2976671) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.556	3
UniProt:Q9BYQ0 KRTAP9-8	1	KRTAP9-8 [cytosol] (R-HSA-6809953)	0.556	3
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.556	3
IntAct:EBI-22311199 CCSB ORF ID			0.556	3
UniProt:Q8WUG5 SLC22A17	1	SLC22A17 [plasma membrane] (R-HSA-561099)	0.556	3
IntAct:EBI-25846222 CCSB			0.556	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.556	3
UniProt:O15460 P4HA2	1	P4HA2 [endoplasmic reticulum lumen] (R-HSA-2980974)	0.534	2
UniProt:Q9UBS9 SUCO			0.527	2
UniProt:Q2GL86 Q2GL86			0.508	3
UniProt:Q03518 TAP1	3	TAP1 [phagocytic vesicle membrane] (R-HSA-1236845) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [endoplasmic reticulum membrane] (R-HSA-947474)	0.499	4
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.463	2
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2

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