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p-PNPLA2 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8956923
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
PNPLA2, Patatin-like phospholipase domain-containing protein 2 ecNumber3.1.1.3/ecNumber, PLPL2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
p-PNPLA2 [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
p-PNPLA2 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96AD5 PNPLA2
Gene Names
PNPLA2, ATGL, FP17548
Chain
chain:1-504
Reference Genes
BioGPS Gene:57104 PNPLA2
COSMIC (genes):PNPLA2 PNPLA2
CTD Gene:57104 PNPLA2
dbSNP Gene:57104 PNPLA2
ENSEMBL:ENSG00000177666 PNPLA2
HGNC:30802 PNPLA2
KEGG:hsa:57104 PNPLA2
Monarch:57104 PNPLA2
NCBI Gene:57104 PNPLA2
OMIM:609059 PNPLA2
UCSC:Q96AD5 PNPLA2
Reference Transcript
RefSeq:NM_020376.3 PNPLA2
RefSeq:XM_017018028.1 PNPLA2
Other Identifiers
11730221_at
11730222_x_at
11730223_a_at
16720353
212705_PM_x_at
212705_x_at
3316288
3316289
3316290
3316291
3316293
3316294
3316295
3316296
3316297
3316298
3316299
3316300
3316301
3316302
3316303
3316304
3316305
3316306
3316307
3316308
3316309
3316310
3316312
39854_3p_r_at
39854_PM_r_at
39854_r_at
4919656_3p_s_at
57104
7937485
A_14_P130284
A_23_P10077
GO:0003824
GO:0004465
GO:0004623
GO:0004806
GO:0005515
GO:0005654
GO:0005737
GO:0005788
GO:0005789
GO:0005811
GO:0005829
GO:0005886
GO:0006629
GO:0006651
GO:0010891
GO:0010898
GO:0016020
GO:0016042
GO:0016411
GO:0016740
GO:0016787
GO:0019433
GO:0019915
GO:0034389
GO:0035356
GO:0036155
GO:0042572
GO:0043226
GO:0044242
GO:0050253
GO:0051264
GO:0051265
GO:0055088
GO:0160077
GO:1905691
HMNXSV003002929
Hs.118463.0.S1_3p_s_at
ILMN_1787923
PH_hs_0006526
TC11000032.hg
Participates
as a member of
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
PNPLA2 [lipid droplet]
PNPLA2 [endoplasmic reticulum lumen]
PNPLA2 [endoplasmic reticulum membrane]
Inferred To
phospho-atgl-1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
phospho-bmm [endoplasmic reticulum lumen]
(Drosophila melanogaster)
phospho-p-PNPLA2 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
phospho-pnpla2 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
phospho-PNPLA2 [endoplasmic reticulum lumen]
(Bos taurus)
phospho-PNPLA2 [endoplasmic reticulum lumen]
(Canis familiaris)
phospho-PNPLA2 [endoplasmic reticulum lumen]
(Gallus gallus)
phospho-PNPLA2 [endoplasmic reticulum lumen]
(Sus scrofa)
phospho-Pnpla2 [endoplasmic reticulum lumen]
(Mus musculus)
phospho-Pnpla2 [endoplasmic reticulum lumen]
(Rattus norvegicus)
Homologues of p-PNPLA2 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Homologues of p-PNPLA2 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
phospho-dob [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
XP_016873517.1
,
NP_065109.1
Guide to Pharmacology - Targets
3253
ENSEMBL
ENST00000336615
,
ENSP00000337701
OpenTargets
ENSG00000177666
IntEnz
3.1.1.4
HPA
ENSG00000177666-PNPLA2
PRO
Q96AD5
Pharos - Targets
Q96AD5
GlyGen
Q96AD5
Orphanet
PNPLA2
HMDB Protein
HMDBP07347
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P09917 ALOX5
6
p-S272-ALOX5 [nuclear envelope]
(R-HSA-2318765)
ALOX5 [cytosol]
(R-HSA-429010)
ALOX5 [secretory granule lumen]
(R-HSA-6801306)
ALOX5 [extracellular region]
(R-HSA-6806468)
ALOX5 [ficolin-1-rich granule lumen]
(R-HSA-6801302)
p-S272-ALOX5 [cytosol]
(R-HSA-265276)
0.527
2
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