Reactome | p-LGALS1 [endoplasmic reticulum lumen]

p-LGALS1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8957003

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

LGALS1, Galectin-1, LEG1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P09382 LGALS1

Gene Names

LGALS1

Chain

initiator methionine:, chain:2-135

Reference Genes

BioGPS Gene:3956 LGALS1

COSMIC (genes):LGALS1 LGALS1

CTD Gene:3956 LGALS1

dbSNP Gene:3956 LGALS1

ENSEMBL:ENSG00000100097 LGALS1

HGNC:6561 LGALS1

KEGG:hsa:3956 LGALS1

Monarch:3956 LGALS1

NCBI Gene:3956 LGALS1

OMIM:150570 LGALS1

UCSC:P09382 LGALS1

Reference Transcript

RefSeq:NM_002305.3 LGALS1

Other Identifiers

11743721_at

16929855

201105_PM_at

201105_at

33412_at

3944884

3944885

3944887

3944888

3944889

3944890

3944891

3944892

3944893

3944894

3944895

3944897

3944898

3944899

3956

80667_f_at

8072876

A_23_P166459

GE80497

GO:0002317

GO:0002376

GO:0003723

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005788

GO:0005829

GO:0005886

GO:0006915

GO:0007155

GO:0007165

GO:0012501

GO:0030154

GO:0030246

GO:0030312

GO:0030395

GO:0031012

GO:0031295

GO:0042981

GO:0043065

GO:0043123

GO:0043226

GO:0043236

GO:0045445

GO:0046598

GO:0048018

GO:0050729

GO:0062023

GO:0070062

GO:0098609

GO:0098772

GO:1990724

GO:2000329

HMNXSV003050354

ILMN_1723978

J04456_at

PH_hs_0024712

TC22000285.hg

g6006015_3p_at

g6006015_3p_x_at

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

LGALS1 [endoplasmic reticulum lumen]

Inferred To

phospho-lec-2 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-p-LGALS1 [endoplasmic reticulum lumen] (Bos taurus)

phospho-p-LGALS1 [endoplasmic reticulum lumen] (Gallus gallus)

phospho-p-LGALS1 [endoplasmic reticulum lumen] (Mus musculus)

phospho-p-LGALS1 [endoplasmic reticulum lumen] (Rattus norvegicus)

phospho-lgals1.1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

phospho-LGALS1 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-LGALS1 [endoplasmic reticulum lumen] (Sus scrofa)

phospho-Dmel\CG13950 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_002296.1

OpenTargets

ENSG00000100097

ENSEMBL

ENST00000215909, ENSP00000215909

ZINC - Substances

LEG1_HUMAN

ZINC target

P09382

PRO

P09382

GlyGen

P09382

PDB

4Q2F, 4Q27, 4Y1V, 1GZW, 4Q26, 7LTA, 4Y1Y, 4Y20, 3T2T, 8B0W, 4Y1X, 3OY8, 6B94, 4Y1Z, 4XBL, 4Y22, 8B0Z, 4Y24, 3W58, 8R74, 5MWX, 2ZKN, 6F83, 6M5Y, 3OYW, 4Q1R, 4Q1P, 5MWT, 1W6M, 2KM2, 7NML, 1W6O, 8OJP, 1W6N, 1W6Q, 4Y1U, 1W6P, 3W59

ZINC - Investigational

LEG1_HUMAN

HPA

ENSG00000100097-LGALS1

Pharos - Targets

P09382

ZINC - Predictions - Purchasable

LEG1_HUMAN

HMDB Protein

HMDBP02427

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13740 ALCAM	1	ALCAM [plasma membrane] (R-HSA-197750)	0.704	5
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.675	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.643	5
UniProt:P35968 KDR	5	p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103) VEGFR2 [plasma membrane] (R-HSA-195382) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636)	0.602	3
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.558	2
UniProt:P02649 APOE	10	APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [extracellular region] (R-HSA-174646) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581)	0.556	3
UniProt:P02751 FN1	10	FN1(32-2386) [extracellular region] (R-HSA-54851) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620)	0.527	2
UniProt:Q6IPR3 TYW3	1	TYW3 [cytoplasm] (R-HSA-6782888)	0.527	2
UniProt:O00533 CHL1	1	CHL1 [plasma membrane] (R-HSA-443615)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	10
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.527	3
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.527	3

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