Reactome | p-NUCB1 [endoplasmic reticulum lumen]

p-NUCB1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8957027

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

NUCB1, Nucleobindin-1, NUCB1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q02818 NUCB1

Gene Names

NUCB1, NUC

Chain

signal peptide:1-26, chain:27-461

Reference Genes

BioGPS Gene:4924 NUCB1

COSMIC (genes):NUCB1 NUCB1

CTD Gene:4924 NUCB1

dbSNP Gene:4924 NUCB1

ENSEMBL:ENSG00000104805 NUCB1

HGNC:8043 NUCB1

KEGG:hsa:4924 NUCB1

Monarch:4924 NUCB1

NCBI Gene:4924 NUCB1

OMIM:601323 NUCB1

UCSC:Q02818 NUCB1

Reference Transcript

Other Identifiers

11751049_a_at

11751050_x_at

11755969_a_at

16863884

200646_PM_s_at

200646_s_at

200649_PM_at

200649_at

3838018

3838020

3838021

3838022

3838023

3838024

3838025

3838026

3838029

3838030

3838031

3838032

3838033

3838034

3838035

3838036

3838037

3838038

3838039

3838040

3838041

3838042

3838043

3838044

3838045

3838047

3846186

40817_at

4924

8030133

A_23_P78771

GE58173

GE81604

GO:0001965

GO:0003677

GO:0005085

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005788

GO:0005793

GO:0005794

GO:0007264

GO:0016020

GO:0043226

GO:0046872

GO:0070062

GO:0098772

HMNXSV003019333

ILMN_1722634

PH_hs_0010324

TC19000712.hg

TC19000714.hg

U31342_at

g12803104_3p_at

g5453817_3p_a_at

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

NUCB1 [endoplasmic reticulum lumen]

Inferred To

phospho-p-NUCB1 [endoplasmic reticulum lumen] (Mus musculus)

phospho-p-NUCB1 [endoplasmic reticulum lumen] (Rattus norvegicus)

phospho-nucb-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-NUCB1 [endoplasmic reticulum lumen] (Bos taurus)

phospho-NUCB1 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-NUCB1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

phospho-NUCB1 [endoplasmic reticulum lumen] (Sus scrofa)

phospho-nucb1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_006175.2, XP_016882334.1

Guide to Pharmacology - Targets

2871

ENSEMBL

ENST00000451312, ENST00000405315, ENST00000706746, ENSP00000385211, ENSP00000516525, ENST00000407032, ENSP00000410519, ENSP00000397201, ENST00000411700, ENSP00000385923

OpenTargets

ENSG00000104805

HPA

ENSG00000104805-NUCB1

PRO

Q02818

Pharos - Targets

Q02818

GlyGen

Q02818

HMDB Protein

HMDBP07855

PDB

1SNL

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P10823	5	GNAT1 [cytosol] (R-SCE-2565915) N-(C14:0)-GNAT1 [photoreceptor disc membrane] (R-SCE-2534062) GNAT1 (Met removed) [cytosol] (R-SCE-2534043) GNAZ [plasma membrane] (R-SCE-167416) GNAI3 [plasma membrane] (R-SCE-55365)	0.556	3
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	2
UniProt:P08254 MMP3	6	MMP3(100-477) [extracellular region] (R-HSA-1430778) MMP3 [extracellular region] (R-HSA-8943665) MMP3(18-477) [extracellular region] (R-HSA-1604707) MMP3(55-477) [extracellular region] (R-HSA-1604735) MMP3(18-54) [extracellular region] (R-HSA-1604705) MMP3(55-99) [extracellular region] (R-HSA-1604687)	0.527	2
UniProt:Q8TBF2 PRXL2B	1	FAM213B [cytosol] (R-HSA-2142703)	0.527	2
UniProt:P18509 ADCYAP1	4	ADCYAP1(132-158) [extracellular region] (R-HSA-420144) ADCYAP1(82-129) [extracellular region] (R-HSA-420254) ADCYAP1(132-169) [extracellular region] (R-HSA-420282) ADCYAP1(2-742) [Golgi membrane] (R-HSA-187679)	0.527	2

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