Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-C3 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8957056
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
C3, Complement C3, CO3_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
p-C3 [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
p-C3 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01024 C3
Gene Names
C3, CPAMD1
Chain
signal peptide:1-22, chain:23-1663, chain:23-667, chain:569-667, chain:672-1663, chain:672-748, chain:672-747, chain:749-1663, chain:749-954, chain:955-1303, chain:955-1001, chain:1002-1303, peptide:1304-1320, chain:1321-1663
Reference Genes
COSMIC (genes):C3 C3
dbSNP Gene:718 C3
ENSEMBL:ENSG00000125730 C3
Participates
as a member of
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
C3d fragment [extracellular region]
C3 alpha chain [azurophil granule lumen]
C3 beta chain [azurophil granule lumen]
C3 alpha chain [secretory granule lumen]
C3 beta chain [secretory granule lumen]
C3 [endoplasmic reticulum lumen]
C3c alpha' chain fragment 1 precursor [extracellular region]
C3c alpha' chain fragment 2 [extracellular region]
C3c alpha' chain fragment 1 [extracellular region]
C3a-desArg [extracellular region]
C3dg [plasma membrane]
C3d [plasma membrane]
C3f [extracellular region]
C3 beta chain [plasma membrane]
C3c alpha' chain fragment 1 precursor [plasma membrane]
C3c alpha' chain fragment 2 [plasma membrane]
C3 alpha chain [extracellular region]
C3b alpha' [extracellular region]
C3 beta chain [extracellular region]
dNQ-C3(672-1663) [extracellular region]
C3a [extracellular region]
Inferred To
Homologues of p-C3 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
phospho-LOC100491968 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
phospho-LOC100170611 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
phospho-C3 [endoplasmic reticulum lumen]
(Bos taurus)
phospho-C3 [endoplasmic reticulum lumen]
(Canis familiaris)
phospho-C3 [endoplasmic reticulum lumen]
(Mus musculus)
phospho-C3 [endoplasmic reticulum lumen]
(Rattus norvegicus)
phospho-C3 [endoplasmic reticulum lumen]
(Sus scrofa)
phospho-p-C3 [endoplasmic reticulum lumen]
(Gallus gallus)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-12735745 C3B
0.801
12
UniProt:P08603 CFH
1
CFH [extracellular region]
(R-HSA-976788)
0.743
6
UniProt:P20023 CR2
1
CR2 [plasma membrane]
(R-HSA-197936)
0.719
4
UniProt:P15529 CD46
1
CD46 [plasma membrane]
(R-HSA-977362)
0.623
2
UniProt:O60741 HCN1
1
HCN1 [plasma membrane]
(R-HSA-977503)
0.623
7
UniProt:Q92496-1 CFHR4
0.609
5
UniProt:Q9Y279-1 VSIG4
0.591
5
ChEBI:28304 HEPARIN
0.589
2
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:O95994 AGR2
0.556
3
UniProt:O95967 EFEMP2
1
EFEMP2 [extracellular region]
(R-HSA-2161231)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:P35219 CAH8
0.527
2
UniProt:Q9H8H2 DDX31
0.527
2
UniProt:Q16659 MAPK6 gene
6
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
MAPK6 [cytosol]
(R-HSA-5686979)
ub-MAPK6 [cytosol]
(R-HSA-5687000)
0.527
2
UniProt:Q9Y279-2 VSIG4
0.524
2
UniProt:Q13936 CACNA1C
1
CACNA1C [plasma membrane]
(R-HSA-265551)
0.499
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text