Reactome | SEPHS2 phosphorylates H2Se to form SELP

SEPHS2 phosphorylates H2Se to form SELP

Stable Identifier

R-HSA-8959510

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Selenoproteins are proteins that incorporate the nonstandard amino acid selenocysteine (Sec) in response to the UGA codon. Sec is synthesised in several steps from hydrogen selenide (H2Se), an intermediate formed from dietary sources of selenium. In the first step, cytosolic selenide water dikinase 2 (SEPHS2 aka SPS2) mediates the phosphorylation of H2Se using ATP as the phosphate donor, forming selenophosphate (SELP) (Tamura et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15534230	Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation Stadtman, TC, Tamura, T, Sakaguchi, H, Takahata, M, Tanaka, H, Yamamoto, S, Inagaki, K	Proc. Natl. Acad. Sci. U.S.A.	2004