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TFRC(1-760) [endosome membrane]
Stable Identifier
R-HSA-8961829
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
TFRC, Transferrin receptor protein 1
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
Fe3+ dissociates from holoTF:TFRC dimer (Homo sapiens)
apoTF:TFRC dimer [endosome membrane] (Homo sapiens)
TFRC dimer [endosome membrane] (Homo sapiens)
TFRC(1-760) [endosome membrane] (Homo sapiens)
holoTF:TFRC dimer [endosome membrane] (Homo sapiens)
TFRC dimer [endosome membrane] (Homo sapiens)
TFRC(1-760) [endosome membrane] (Homo sapiens)
apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Homo sapiens)
apoTF:TFRC dimer [endosome membrane] (Homo sapiens)
TFRC dimer [endosome membrane] (Homo sapiens)
TFRC(1-760) [endosome membrane] (Homo sapiens)
holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Homo sapiens)
holoTF:TFRC dimer [endosome membrane] (Homo sapiens)
TFRC dimer [endosome membrane] (Homo sapiens)
TFRC(1-760) [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02786 TFRC
Gene Names
TFRC
Chain
chain:1-760, chain:101-760
Reference Genes
BioGPS Gene:7037 TFRC
COSMIC (genes):TFRC TFRC
CTD Gene:7037 TFRC
dbSNP Gene:7037 TFRC
ENSEMBL:ENSG00000072274 TFRC
ENSEMBL_homo_sapiens_GENE:ENSG00000072274.14 TFRC
HGNC:11763 TFRC
KEGG Gene (Homo sapiens):7037 TFRC
Monarch:7037 TFRC
NCBI Gene:7037 TFRC
OMIM:190010 TFRC
UCSC:P02786 TFRC
Reference Transcript
RefSeq:NM_001313966.1 TFRC
RefSeq:NM_001313965.1 TFRC
RefSeq:NM_003234.3 TFRC
RefSeq:NM_001128148.2 TFRC
Other Identifiers
11715477_at
11715478_a_at
11756156_s_at
16963241
207332_PM_s_at
207332_s_at
208691_PM_at
208691_at
237215_PM_s_at
237215_s_at
2712637
2712638
2712639
2712640
2712641
2712642
2712643
2712645
2712650
2712652
2712654
2712658
2712660
2712664
2712665
2712668
2712669
2712671
2712675
2712676
2712677
2712678
2712679
2712681
2712683
2712684
2712685
37324_at
7037
8093053
AFFX-HUMTFRR/M11507_3_at
AFFX-HUMTFRR/M11507_5_at
AFFX-HUMTFRR/M11507_M_at
A_23_P212617
GE81249
GO:0001618
GO:0001666
GO:0001934
GO:0002376
GO:0003013
GO:0003723
GO:0003725
GO:0004998
GO:0005515
GO:0005576
GO:0005615
GO:0005768
GO:0005769
GO:0005886
GO:0005905
GO:0006310
GO:0006351
GO:0006355
GO:0006826
GO:0006879
GO:0006897
GO:0006953
GO:0006954
GO:0007005
GO:0007155
GO:0007165
GO:0007584
GO:0009897
GO:0009986
GO:0010008
GO:0010033
GO:0010035
GO:0010039
GO:0010042
GO:0010628
GO:0010637
GO:0012501
GO:0016020
GO:0016192
GO:0016323
GO:0019901
GO:0023052
GO:0030154
GO:0030316
GO:0030544
GO:0030669
GO:0030890
GO:0031334
GO:0031410
GO:0031623
GO:0032526
GO:0033138
GO:0033572
GO:0035556
GO:0036211
GO:0038024
GO:0042102
GO:0042470
GO:0042802
GO:0042803
GO:0043066
GO:0043123
GO:0043226
GO:0043231
GO:0044877
GO:0045780
GO:0045830
GO:0046688
GO:0046718
GO:0048471
GO:0048856
GO:0051087
GO:0051092
GO:0055037
GO:0055038
GO:0055065
GO:0065003
GO:0070062
GO:0071466
GO:0072562
GO:0150104
GO:1900182
GO:1903561
GO:1990712
GO:1990830
HMNXSV003030758
PH_hs_0022877
TC03002155.hg
X01060_at
g4507456_3p_a_at
Participates
as a component of
TFRC dimer [endosome membrane] (Homo sapiens)
Other forms of this molecule
TFRC(1-760) [clathrin-coated endocytic vesicle membrane]
TFRC(1-760) [Golgi membrane]
TFRC(1-760) [cytoplasmic vesicle membrane]
TFRC(1-760) [plasma membrane]
Inferred To
TFRC(1-760) [endosome membrane]
(Gallus gallus)
Homologues of TFRC(1-760) [endosome membrane]
(Sus scrofa)
TFRC [endosome membrane]
(Bos taurus)
TFRC [endosome membrane]
(Sus scrofa)
Tfrc [endosome membrane]
(Mus musculus)
Tfrc [endosome membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001121620.1
,
NP_003225.2
,
NP_001300894.1
,
NP_001300895.1
Guide to Pharmacology - Targets
3196
OpenTargets
ENSG00000072274
GeneCards
P02786
HPA
ENSG00000072274-TFRC
Ensembl
ENSP00000513646
,
ENSP00000353224
,
ENST00000698280
,
ENSG00000072274
,
ENSP00000513654
,
ENST00000392396
,
ENSP00000376197
,
ENST00000698291
,
ENST00000360110
PRO
P02786
Pharos - Targets
P02786
Orphanet
24978
HMDB Protein
HMDBP02577
PDB
8P0Z
,
7ZQS
,
6GSR
,
1DE4
,
6H5I
,
6D05
,
2NSU
,
3S9L
,
1SUV
,
1CX8
,
3S9M
,
6WRW
,
6D03
,
6WRV
,
6OKD
,
6WRX
,
3KAS
,
6D04
,
3S9N
,
6W3H
,
6Y76
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02787 TF
6
apoTF [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869140)
TF [secretory granule lumen]
(R-HSA-350704)
apoTF [extracellular region]
(R-HSA-350754)
apoTF [endosome membrane]
(R-HSA-917974)
p-TF [endoplasmic reticulum lumen]
(R-HSA-8957001)
TF [endoplasmic reticulum lumen]
(R-HSA-8956763)
0.852
7
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.671
4
UniProt:Q9P0V3 SH3BP4
1
SH3BP4 [cytosol]
(R-HSA-8866227)
0.668
6
UniProt:Q30201 HFE
1
HFE [plasma membrane]
(R-HSA-5691126)
0.621
3
UniProt:P21926 CD9
4
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.597
3
UniProt:P61769 B2M
11
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [plasma membrane]
(R-HSA-167743)
0.564
3
UniProt:P02768 ALB
7
ALB(19-609) [extracellular region]
(R-HSA-114609)
ALB [platelet alpha granule lumen]
(R-HSA-49865)
salicyl-ALB [extracellular region]
(R-HSA-9750694)
acetyl-ALB [extracellular region]
(R-HSA-9749660)
ALB [extracellular region]
(R-HSA-194115)
p-ALB [endoplasmic reticulum lumen]
(R-HSA-8956930)
ALB [endoplasmic reticulum lumen]
(R-HSA-8956690)
0.558
2
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:Q14973 SLC10A1
1
SLC10A1 [plasma membrane]
(R-HSA-194116)
0.556
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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