LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. CETP (cholesterol ester transfer protein) complexed with cholesterol esters interacts with an LDL (low density lipoprotein) particle, acquiring triacylglycerol molecules and donating cholesterol ester to the LDL (Swenson et al. 1988; Morton & Zilversmit 1983), a key step in the transport of tissue cholesterol to the liver.As an alternative to LDLR-mediated uptake and degradation, a LDL particle can bind a single molecule of LPA (apolipoprotein A), forming a Lp(a) lipoprotein particle (Lobentanz et al. 1998).
Kraft, HG, Sattler, J, Lobentanz, EM, Gruber, A, Dieplinger, H, Brunner, C, Muller, HJ, Krasznai, K, Utermann, G
Brocia, RW, Swenson, TL, Tall, AR
Zilversmit, DB, Morton, RE
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