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Go!
p-Y419-SRC [cytosol]
Stable Identifier
R-HSA-8964276
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor UniProt:O15455 TLR3
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Homo sapiens)
p-Y419-SRC [cytosol] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
G alpha (s):GTP:SRC dissociates (Homo sapiens)
p-Y419-SRC [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12931 SRC
Gene Names
SRC, SRC1
Chain
initiator methionine:, chain:2-536
Reference Genes
BioGPS Gene:6714 SRC
COSMIC (genes):SRC SRC
CTD Gene:6714 SRC
dbSNP Gene:6714 SRC
ENSEMBL:ENSG00000197122 SRC
ENSEMBL_homo_sapiens_GENE:ENSG00000197122.13 SRC
ENSEMBL_homo_sapiens_GENE:ENSG00000291971.1 SRC
HGNC:11283 SRC
KEGG Gene (Homo sapiens):6714 SRC
Monarch:6714 SRC
NCBI Gene:6714 SRC
OMIM:190090 SRC
UCSC:P12931 SRC
Reference Transcript
RefSeq:XM_017028025.1 SRC
RefSeq:XM_017028027.1 SRC
RefSeq:NM_005417.4 SRC
RefSeq:XM_017028026.1 SRC
RefSeq:NM_198291.2 SRC
RefSeq:XM_011529013.2 SRC
RefSeq:XM_017028024.1 SRC
Other Identifiers
11723135_s_at
11723136_x_at
1558211_PM_s_at
1558211_s_at
16913413
1938_at
213324_PM_at
213324_at
221284_PM_s_at
221284_s_at
3884193
3884196
3884198
3884199
3884200
3884202
3884203
3884207
3884209
3884210
3884214
3884215
3884216
3884221
3884223
3884227
3884228
3884229
38904_at
6714
8062377
A_14_P111562
A_23_P308603
GE81507
GO:0000166
GO:0001545
GO:0001819
GO:0002102
GO:0002223
GO:0002376
GO:0002862
GO:0003013
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005080
GO:0005102
GO:0005158
GO:0005178
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005743
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005901
GO:0005925
GO:0005975
GO:0006468
GO:0006914
GO:0006954
GO:0007010
GO:0007049
GO:0007155
GO:0007165
GO:0007172
GO:0007173
GO:0007179
GO:0007229
GO:0007283
GO:0007611
GO:0008284
GO:0009410
GO:0009612
GO:0010447
GO:0010628
GO:0010629
GO:0010632
GO:0010634
GO:0010907
GO:0010954
GO:0012501
GO:0014856
GO:0014911
GO:0016004
GO:0016020
GO:0016192
GO:0016236
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0018108
GO:0019899
GO:0019901
GO:0019904
GO:0020037
GO:0022407
GO:0022414
GO:0023052
GO:0030054
GO:0030154
GO:0030168
GO:0030331
GO:0030900
GO:0031234
GO:0031295
GO:0031333
GO:0031410
GO:0031648
GO:0031667
GO:0032200
GO:0032211
GO:0032587
GO:0032869
GO:0033146
GO:0033625
GO:0034139
GO:0034330
GO:0034332
GO:0034446
GO:0034614
GO:0035306
GO:0035331
GO:0035556
GO:0035635
GO:0036035
GO:0036120
GO:0036211
GO:0038096
GO:0038128
GO:0038166
GO:0042060
GO:0042169
GO:0042476
GO:0042542
GO:0043025
GO:0043065
GO:0043066
GO:0043114
GO:0043149
GO:0043154
GO:0043226
GO:0043274
GO:0044294
GO:0044325
GO:0044877
GO:0045056
GO:0045087
GO:0045121
GO:0045124
GO:0045296
GO:0045453
GO:0045747
GO:0045780
GO:0045785
GO:0046579
GO:0046628
GO:0046777
GO:0046875
GO:0048008
GO:0048010
GO:0048011
GO:0048013
GO:0048041
GO:0048471
GO:0048477
GO:0048856
GO:0048870
GO:0050731
GO:0050839
GO:0050847
GO:0050877
GO:0050900
GO:0051057
GO:0051117
GO:0051219
GO:0051222
GO:0051385
GO:0051450
GO:0051602
GO:0051604
GO:0051895
GO:0051897
GO:0051902
GO:0051974
GO:0060065
GO:0060444
GO:0060491
GO:0060576
GO:0065003
GO:0070062
GO:0070102
GO:0070161
GO:0070301
GO:0070374
GO:0070542
GO:0070555
GO:0070700
GO:0071222
GO:0071253
GO:0071375
GO:0071393
GO:0071398
GO:0071456
GO:0071498
GO:0071560
GO:0071803
GO:0071897
GO:0071902
GO:0086091
GO:0090263
GO:0097060
GO:0097110
GO:0098542
GO:0098609
GO:0098772
GO:0098978
GO:0099091
GO:0140096
GO:1900182
GO:1902533
GO:1902737
GO:1903997
GO:1904263
GO:1904385
GO:1904707
GO:1990646
GO:2000256
GO:2000386
GO:2000394
GO:2000588
GO:2000641
GO:2000811
GO:2001237
GO:2001243
GO:2001286
HMNXSV003035331
Hs.198298.0.S1_3p_at
Hs2.383588.1.A1_3p_s_at
ILMN_1685898
ILMN_1729987
K03218_at
PH_hs_0033377
TC20000273.hg
TC20001205.hg
g4885608_3p_a_at
Participates
as an output of
G alpha (s):GTP:SRC dissociates (Homo sapiens)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Homo sapiens)
as a component of
G alpha (s):GTP:p-Y419-SRC [plasma membrane] (Homo sapiens)
G protein alpha (i):GTP:p-Y419-SRC [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y419-SRC [nucleoplasm]
SRC [cytosol]
MyrG-SRC [plasma membrane]
MyrG,p-Y530-SRC [plasma membrane]
MyrG-p-Y419-SRC [plasma membrane]
Inferred To
phospho-SRC [cytosol]
(Canis familiaris)
phospho-p-Y419-SRC [cytosol]
(Bos taurus)
phospho-p-Y419-SRC [cytosol]
(Caenorhabditis elegans)
phospho-p-Y419-SRC [cytosol]
(Danio rerio)
phospho-p-Y419-SRC [cytosol]
(Drosophila melanogaster)
phospho-p-Y419-SRC [cytosol]
(Gallus gallus)
phospho-p-Y419-SRC [cytosol]
(Mus musculus)
phospho-p-Y419-SRC [cytosol]
(Rattus norvegicus)
phospho-p-Y419-SRC [cytosol]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 420
Coordinate
420
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_011527315.1
,
XP_016883514.1
,
NP_005408.1
,
NP_938033.1
,
XP_016883513.1
,
XP_016883515.1
,
XP_016883516.1
ZINC - World Drugs
SRC_HUMAN
Guide to Pharmacology - Targets
2206
OpenTargets
ENSG00000197122
ZINC - FDA approved
SRC_HUMAN
ZINC - Substances
SRC_HUMAN
ZINC target
P12931
ZINC - Biogenic
SRC_HUMAN
PRO
P12931
PDB
6E6E
,
1O4G
,
4F5B
,
1O4R
,
1O4A
,
1O4K
,
6EHJ
,
2BDF
,
1SHD
,
1HCS
,
3ZMQ
,
1A09
,
2BDJ
,
1O41
,
1YOJ
,
6ATE
,
4MXO
,
1O4I
,
1O4P
,
3ZMP
,
1A1E
,
1O4L
,
1O4F
,
4HXJ
,
8GWH
,
1KSW
,
7T1U
,
1O4Q
,
1O49
,
1YI6
,
4F5A
,
1A07
,
1YOL
,
2SRC
,
1O4J
,
6C4S
,
4MXZ
,
1O4N
,
1Y57
,
1A1C
,
1O4D
,
1O47
,
1YOM
,
7NG7
,
4F59
,
1O44
,
1O4H
,
8JF3
,
4MXY
,
1O4E
,
1O48
,
1O4B
,
1HCT
,
1O4O
,
7OTE
,
4MXX
,
1O45
,
1FMK
,
1A08
,
1A1A
,
1O4M
,
4K11
,
1O42
,
1O4C
,
2H8H
,
1O46
,
7YQE
,
8HAQ
,
1A1B
,
3VRO
,
1O43
ZINC - Investigational
SRC_HUMAN
ZINC - Metabolites
SRC_HUMAN
IntEnz
2.7.10.2
GeneCards
P12931
HPA
ENSG00000197122-SRC
Ensembl
ENSG00000197122
,
ENST00000358208
,
ENSP00000509325
,
ENSP00000508666
,
ENST00000373558
,
ENSP00000362659
,
ENST00000692112
,
ENSP00000362668
,
ENSP00000350941
,
ENSP00000362680
,
ENST00000373578
,
ENST00000692423
,
ENST00000373567
Pharos - Targets
P12931
Orphanet
25273
ZINC - Predictions - Purchasable
SRC_HUMAN
Interactors (76)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.937
14
UniProt:Q05397 PTK2
11
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.924
9
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.9
9
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.848
12
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.845
8
UniProt:Q9H5V8 CDCP1
0.793
5
UniProt:P08581 MET
7
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.787
7
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.779
7
UniProt:P35968 KDR
5
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.77
6
UniProt:Q13444 ADAM15
1
ADAM15 [plasma membrane]
(R-HSA-708329)
0.75
4
UniProt:P15941 MUC1
19
MUC1(24-1255) [plasma membrane]
(R-HSA-6793976)
Core 8 (MUC1) [Golgi lumen]
(R-HSA-1462219)
Core 2S (MUC1) [Golgi lumen]
(R-HSA-6786333)
Core 5 (MUC1) [Golgi lumen]
(R-HSA-1462231)
Core 4 (MUC1) [Golgi lumen]
(R-HSA-1462154)
Core 3 (MUC1) [Golgi lumen]
(R-HSA-1462068)
Core 7 (MUC1) [Golgi lumen]
(R-HSA-1462105)
extended Core 6 (MUC1) [Golgi lumen]
(R-HSA-1967019)
Core 6 (MUC1) [Golgi lumen]
(R-HSA-1462085)
MUC1(24-1255) [Golgi lumen]
(R-HSA-913611)
Disialyl T-antigen (MUC1) [Golgi lumen]
(R-HSA-1463518)
Sialyl T-antigen (MUC1) [Golgi lumen]
(R-HSA-1463531)
Sialyl-2,3 T-antigen (MUC1) [Golgi lumen]
(R-HSA-1463483)
T-antigen (MUC1) [Golgi lumen]
(R-HSA-1462359)
Sialyl Tn antigen (MUC1) [Golgi lumen]
(R-HSA-1463526)
GalNAc-MUC1(24-1255) [Golgi lumen]
(R-HSA-913642)
Core 2a (MUC1) [Golgi lumen]
(R-HSA-6784286)
Core 2 (MUC1) [Golgi lumen]
(R-HSA-1462167)
GalNAc-MUC1(24-1255) [plasma membrane]
(R-HSA-8858449)
0.748
5
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.734
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.708
6
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.708
11
UniProt:P56945 BCAR1
4
p-Y-BCAR1 [cytosol]
(R-HSA-372645)
p-Y12-BCAR1 [cytosol]
(R-HSA-5218739)
p-Y165,Y664-BCAR1 [cytosol]
(R-HSA-8848723)
BCAR1 [cytosol]
(R-HSA-201625)
0.688
3
UniProt:Q01973 ROR1
2
ROR1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140727)
ROR1 [plasma membrane]
(R-HSA-197814)
0.682
9
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.669
5
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
LYN [plasma membrane]
(R-HSA-197943)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
LYN [cytosol]
(R-HSA-354251)
0.669
4
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.669
3
UniProt:Q9H204 MED28
1
MED28 [nucleoplasm]
(R-HSA-6804546)
0.656
3
UniProt:Q8WUM4 PDCD6IP
1
PDCD6IP [cytosol]
(R-HSA-917717)
0.653
7
UniProt:P55196 AFDN
0.65
7
UniProt:Q14289 PTK2B
3
p-Y-PTK2B [cytosol]
(R-HSA-508515)
PTK2B [cytosol]
(R-HSA-390932)
PTK2B [cytosol]
(R-HSA-5218721)
0.643
3
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.623
3
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.621
3
UniProt:P07550 ADRB2
5
pS-ADRB2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869143)
ADRB2 [endosome membrane]
(R-HSA-6783036)
PolyUb-ADRB2 [endosome membrane]
(R-HSA-6783066)
pS-ADRB2 [plasma membrane]
(R-HSA-8852158)
ADRB2 [plasma membrane]
(R-HSA-390647)
0.611
3
UniProt:Q9ULH1 ASAP1
1
ASAP1 [cytosol]
(R-HSA-5620905)
0.609
3
UniProt:P35326 SPRR2A
2
SPRR2A [cornified envelope]
(R-HSA-8934850)
SPRR2A [cytosol]
(R-HSA-6810863)
0.602
3
UniProt:Q62884 Q62884
0.602
3
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.593
6
UniProt:Q68CZ2 TNS3
1
TNS3 [cytosol]
(R-HSA-8875524)
0.591
13
UniProt:P27635 RPL10
1
RPL10 [cytosol]
(R-HSA-72402)
0.591
6
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.59
3
UniProt:P00519 ABL1
6
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
0.589
2
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.573
3
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.571
2
UniProt:P34152 Ptk2
13
phospho-pY-PTK2 [cytosol]
(R-MMU-9632393)
phospho-p-6Y-PTK2 [cytosol]
(R-MMU-354128)
phospho-p-Y397-PTK2 [cytosol]
(R-MMU-354068)
PTK2 [cytosol]
(R-MMU-201621)
PTK2(1-772) [cytosol]
(R-MMU-202827)
PTK2(773-1052) [cytosol]
(R-MMU-202829)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-MMU-5218694)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-MMU-5229006)
phospho-p-5Y-PTK2 [cytosol]
(R-MMU-5218711)
Fak1 [cytosol]
(R-MMU-3928448)
p-Y428-FAK1 [cytosol]
(R-MMU-3928397)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-MMU-8874600)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-MMU-8874613)
0.564
2
UniProt:P68400 CSNK2A1
2
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
CSNK2A1 [cytosol]
(R-HSA-201713)
0.564
2
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.564
2
linoleoyl-CoA [ChEBI:15530]
2
LA-CoA [endoplasmic reticulum lumen]
(R-ALL-2046063)
LIN-CoA [mitochondrial matrix]
(R-ALL-77359)
0.558
2
ChEBI:15532 MYRISTOYL-COA
0.558
2
UniProt:O43184 ADAM12
1
ADAM12 [plasma membrane]
(R-HSA-179792)
0.558
2
UniProt:Q8R5G7
1
Arap3 [cytosol]
(R-MMU-195185)
0.558
3
UniProt:Q9BR61 ACBD6
1
ACBD6 [cytosol]
(R-HSA-8848243)
0.558
4
UniProt:P27986-2 PIK3R1
0.556
3
UniProt:Q13829 TNFAIP1
1
TNFAIP1 [cytosol]
(R-HSA-9696531)
0.556
3
UniProt:Q9UNY5 ZN232
0.556
3
UniProt:Q14693 LPIN1
3
p-S106-LPIN1 [nucleoplasm]
(R-HSA-4419936)
LPIN1 [nuclear envelope]
(R-HSA-4419927)
LPIN1 [endoplasmic reticulum membrane]
(R-HSA-549157)
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
3
UniProt:O14796 SH2D1B
1
SH2D1B [cytosol]
(R-HSA-5685187)
0.556
3
UniProt:Q13322-4 GRB10
0.556
3
UniProt:Q6XD76 ASCL4
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
6
UniProt:Q15907 RAB11B
3
RAB11B [recycling endosome membrane]
(R-HSA-8854762)
GGC-RAB11B [cytosol]
(R-HSA-8873766)
RAB11B [cytosol]
(R-HSA-8873671)
0.556
3
UniProt:O60880 SH2D1A
1
SH2D1A [cytosol]
(R-HSA-5685108)
0.556
3
UniProt:Q14457 BECN1
4
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.556
3
UniProt:Q9BU70 TRMO
0.547
2
UniProt:P97288
1
Htr4 [plasma membrane]
(R-MMU-391008)
0.544
2
UniProt:O14672 ADAM10
6
ADAM10(215-824) [plasma membrane]
(R-HSA-179885)
ADAM10 [plasma membrane]
(R-HSA-157237)
ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956768)
p-ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956999)
ADAM10 [tertiary granule membrane]
(R-HSA-6800992)
ADAM10 [specific granule membrane]
(R-HSA-6799566)
0.544
3
UniProt:P25962
1
Adrb3 [plasma membrane]
(R-MMU-390623)
0.544
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.544
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.527
5
UniProt:P05023 ATP1A1
1
ATP1A1 [plasma membrane]
(R-HSA-936850)
0.527
5
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.527
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.527
2
UniProt:P19367 HK1
4
HK1 T680S [cytosol]
(R-HSA-5621880)
HK1 H577_C672del [cytosol]
(R-HSA-5621873)
HK1 L529S [cytosol]
(R-HSA-5621861)
HK1 [cytosol]
(R-HSA-70395)
0.524
2
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.524
2
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.524
2
UniProt:Q9H3S7 PTPN23
1
PTPN23 [nucleoplasm]
(R-HSA-9008924)
0.499
2
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.499
3
ChEBI:39112 BOSUTINIB
0.499
2
ChEBI:45783 IMATINIB
0.499
2
UniProt:P12830 CDH1
8
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
4
UniProt:O15455 TLR3
6
TLR3 E746* [endosome membrane]
(R-HSA-5602730)
TLR3 P554S [endosome membrane]
(R-HSA-5602428)
TLR3 [endoplasmic reticulum membrane]
(R-HSA-1679057)
TLR3 [endolysosome membrane]
(R-HSA-167941)
TLR3 [Golgi membrane]
(R-HSA-1678955)
TLR3 [endosome membrane]
(R-HSA-2000341)
0.463
2
UniProt:P23743 DGKA
1
DGKA [plasma membrane]
(R-HSA-426056)
0.462
2
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