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G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
Stable Identifier
R-HSA-8964329
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Homo sapiens)
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G-Protein Coupled Receptors sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(i) subunit alpha (GNAI) can directly bind to proto-oncogene tyrosine-protein kinase Src (SRC). When bound to active GNAI, SRC can autophosphorylate the 416-tyrosine residue. Upon autophosphorylation, SRC dissociates from GNAI and is subsequently activated. GNAI increases SRC enzymatic activity by decreasing Km and not affecting Vm. Physiologically, the SRC family have implications in cell growth and cancer.
Literature References
PubMed ID
Title
Journal
Year
11007482
Src tyrosine kinase is a novel direct effector of G proteins
Lowry, W
,
Ali, S
,
Huang, XY
,
Huang, J
,
Ma, YC
Cell
2000
Participants
Input
G protein alpha (i):GTP:p-Y419-SRC [plasma membrane]
(Homo sapiens)
Output
G alpha (i): GTP [plasma membrane]
(Homo sapiens)
p-Y419-SRC [cytosol]
(Homo sapiens)
Participates
as an event of
G alpha (i) signalling events (Homo sapiens)
Orthologous Events
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Bos taurus)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Caenorhabditis elegans)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Canis familiaris)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Danio rerio)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Drosophila melanogaster)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Gallus gallus)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Mus musculus)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Rattus norvegicus)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Sus scrofa)
Authored
Varusai, TM (2017-07-27)
Reviewed
Huang, X (2018-09-13)
Created
Varusai, TM (2017-02-16)
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