Reactome | Gq-BTK complex dissociates to Active BTK and Gq

Gq-BTK complex dissociates to Active BTK and Gq

Stable Identifier

R-HSA-8964340

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Gq-BTK complex dissociates to Active BTK and Gq

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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(q) subunit alpha class (GNAQ/GNA11/GNA14/GNA15) can bind to the non-receptor Tyrosine-protein kinase BTK. This binding results in a conformational change in BTK. Subsequently, the structurally modified BTK is released from GNAQ and is now catalytically active. Active BTK can trigger the downstream MAPK p38 pathway. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

Literature References

PubMed ID	Title	Journal	Year
9770463	Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase Huang, XY, Ma, YC	Proc. Natl. Acad. Sci. U.S.A.	1998
9305846	Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit Kozasa, T, Ma, W, Huang, XY, Bence, K	Nature	1997
11742120	Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization Huang, XY, Fulton, DB, Andreotti, AH, Laederach, A, Brazin, KN, Zamoon, J, Cradic, KW	Protein Sci.	2002