Reactome | CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex

CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex

Stable Identifier

R-HSA-8964634

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex

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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. Serine/threonine-protein kinase PAK 1 binds with Rho guanine nucleotide exchange factor 6 (ARHGEF6, PIX-Alpha) in the cytosol and is subsequently translocated by the G-protein beta-gamma complex to the plasma membrane. Here, the GTPase Cell division control protein 42 homolog (CDC42) binds with this complex, following which ARHGEF6 activates CDC42. CDC42 is known to be involved in epithelial cell polarization processes.

Literature References

PubMed ID	Title	Journal	Year
12887923	Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42 Wu, Y, Li, Z, Mo, Z, Smrcka, AV, Huang, CK, Liu, B, Lu, W, Wu, G, Wu, D, Li, L, Liu, M, Hannigan, M	Cell	2003