Nephrin dimer:KIRREL binds FYN

Stable Identifier
R-HSA-8981534
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Nephrin dimer:KIRREL binds FYN
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Nephrin (NPHS1) is tyrosine phosphorylated by the Src family tyrosine kinase FYN in developing and injured podocytes. Phosphorylation of three tyrosines (1176, 1193 and 1217) results in the formation of a preferred binding motif (YDXV) for the SH2 domain of the adaptor protein NCK, which links Nephrin to the cytoskeleton. Phosphorylation of NPHS1 tyrosine 1158 results in a binding motif for the p85 regulatory subunit of PI3K.
Literature References
PubMed ID Title Journal Year
12668668 Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin

Kunkel, R, Wharram, B, Holzman, LB, Verma, R, Kovari, I, Killen, P, Wiggins, RC, Nihalani, D, Wary, KK

J Biol Chem 2003
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Orthologous Events
Nephrin dimer:KIRREL binds FYN (Bos taurus)
Nephrin dimer:KIRREL binds FYN (Caenorhabditis elegans)
Nephrin dimer:KIRREL binds FYN (Canis familiaris)
Nephrin dimer:KIRREL binds FYN (Danio rerio)
Nephrin dimer:KIRREL binds FYN (Drosophila melanogaster)
Nephrin dimer:KIRREL binds FYN (Mus musculus)
Nephrin dimer:KIRREL binds FYN (Rattus norvegicus)
Nephrin dimer:KIRREL binds FYN (Sus scrofa)
Authored
Garapati, P V  (2008-02-26)
de Bono, B  (2008-02-26)
Reviewed
Grahammer, Florian  (2010-05-20)
Huber, TB  (2010-05-20)
Created
Jupe, S  (2017-03-10)
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