Reactome | p-STAT3 [cytosol]

p-STAT3 [cytosol]

Stable Identifier

R-HSA-8982823

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser for interactor UniProt:Q9NWQ8 PAG1

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External Reference Information

External Reference

UniProt:P40763 STAT3

Gene Names

STAT3, APRF

Chain

initiator methionine:, chain:2-770

Reference Genes

BioGPS Gene:6774 STAT3

COSMIC (genes):STAT3 STAT3

CTD Gene:6774 STAT3

dbSNP Gene:6774 STAT3

ENSEMBL:ENSG00000168610 STAT3

ENSEMBL_homo_sapiens_GENE:ENSG00000168610.17 STAT3

HGNC:11364 STAT3

KEGG Gene (Homo sapiens):6774 STAT3

Monarch:6774 STAT3

NCBI Gene:6774 STAT3

OMIM:102582 STAT3

UCSC:P40763 STAT3

Reference Transcript

Other Identifiers

11720755_at

11720756_at

11750674_a_at

16845126

208991_PM_at

208991_at

208992_PM_s_at

208992_s_at

225289_PM_at

225289_at

289_at

3757837

3757839

3757841

3757842

3757844

3757845

3757846

3757848

3757854

3757856

3757858

3757860

3757861

3757862

3757864

3757865

3757867

3757868

3757870

3757871

3757873

3757874

3757875

3757881

3757883

3757885

3757888

3757889

3757905

3757906

39708_at

63330_at

6774

8015607

A_23_P100795

A_23_P107206

A_24_P116805

GE61038

GE61402

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001228

GO:0001659

GO:0001754

GO:0002376

GO:0003677

GO:0003700

GO:0003723

GO:0004879

GO:0005102

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0005975

GO:0006091

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006606

GO:0006886

GO:0006913

GO:0006914

GO:0006952

GO:0006954

GO:0007165

GO:0007166

GO:0007179

GO:0007259

GO:0007399

GO:0008283

GO:0008285

GO:0010467

GO:0010507

GO:0010575

GO:0010628

GO:0010629

GO:0016071

GO:0016310

GO:0019221

GO:0019901

GO:0019903

GO:0019953

GO:0023052

GO:0030154

GO:0030335

GO:0030522

GO:0031047

GO:0031490

GO:0032355

GO:0032731

GO:0032733

GO:0032755

GO:0032757

GO:0032760

GO:0032870

GO:0032991

GO:0033210

GO:0035019

GO:0035591

GO:0035723

GO:0038110

GO:0038113

GO:0038154

GO:0040014

GO:0042127

GO:0042593

GO:0042755

GO:0042789

GO:0042802

GO:0042803

GO:0043226

GO:0043434

GO:0043491

GO:0043565

GO:0044320

GO:0044321

GO:0045648

GO:0045747

GO:0045766

GO:0045820

GO:0045893

GO:0045944

GO:0046983

GO:0048708

GO:0048856

GO:0048870

GO:0050728

GO:0051092

GO:0051726

GO:0055086

GO:0060019

GO:0060089

GO:0060090

GO:0060221

GO:0060259

GO:0060396

GO:0060397

GO:0061629

GO:0070102

GO:0070878

GO:0071310

GO:0072538

GO:0072540

GO:0090575

GO:0097009

GO:0097398

GO:0097696

GO:0106015

GO:0140110

GO:0140297

GO:0140313

GO:0140610

GO:1900017

GO:1901135

GO:1902895

GO:1904685

GO:1905564

GO:2000635

GO:2000737

GO:2001223

HMNXSV003017485

Hs.288544.0.S1_3p_at

ILMN_1663618

ILMN_2401978

ILMN_2410986

L29277_at

PH_hs_0019532

PH_hs_0025138

TC17001531.hg

TC17002638.hg

g12653684_3p_a_at

Participates

as an output of

as a component of

as an input of

p-STAT3 dimerizes (Homo sapiens)

as a member of

Other forms of this molecule

Unfolded STAT3 [cytosol]

p-STAT3 [nucleoplasm]

AcK685- p-Y705,S727-STAT3 [nucleoplasm]

p-Y705,S727-STAT3 [nucleoplasm]

p-S727-STAT3 [cytosol]

p-Y705,S727-STAT3 [cytosol]

p-Y705-STAT3 [nucleoplasm]

p-Y705-STAT3 [cytosol]

STAT3 [cytosol]

p-Y705-STAT3 [cytosol]

p-Y705-STAT3 [nucleoplasm]

Inferred To

phospho-dstD [cytosol] (Dictyostelium discoideum)

phospho-stat3 [cytosol] (Xenopus tropicalis)

phospho-sta-2 [cytosol] (Caenorhabditis elegans)

Homologues of p-STAT3 [cytosol] (Caenorhabditis elegans)

Homologues of p-STAT3 [cytosol] (Dictyostelium discoideum)

Homologues of p-STAT3 [cytosol] (Sus scrofa)

phospho-sta-1 [cytosol] (Caenorhabditis elegans)

phospho-p-STAT3 [cytosol] (Caenorhabditis elegans)

phospho-p-STAT3 [cytosol] (Dictyostelium discoideum)

phospho-dstB [cytosol] (Dictyostelium discoideum)

phospho-Stat92E [cytosol] (Drosophila melanogaster)

phospho-dstA [cytosol] (Dictyostelium discoideum)

phospho-STAT3 [cytosol] (Bos taurus)

phospho-STAT3 [cytosol] (Canis familiaris)

phospho-STAT3 [cytosol] (Gallus gallus)

phospho-STAT3 [cytosol] (Sus scrofa)

phospho-dstC [cytosol] (Dictyostelium discoideum)

phospho-Stat3 [cytosol] (Mus musculus)

phospho-Stat3 [cytosol] (Rattus norvegicus)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

XP_016880464.1, XP_011523447.1, XP_011523448.1, NP_644805.1, XP_005257673.2, NP_998827.1, XP_005257674.2, XP_016880461.1, NP_003141.2

ZINC - World Drugs

STAT3_HUMAN

Guide to Pharmacology - Targets

2994

OpenTargets

ENSG00000168610

ZINC - Substances

STAT3_HUMAN

ZINC target

P40763

ZINC - Biogenic

STAT3_HUMAN

PRO

P40763

PDB

6NUQ, 6TLC, 6NJS, 6QHD, 5U5S, 5AX3

ZINC - Investigational

STAT3_HUMAN

ZINC - Metabolites

STAT3_HUMAN

GeneCards

P40763

HPA

ENSG00000168610-STAT3

Ensembl

ENST00000677723, ENSP00000503102, ENSP00000503574, ENSP00000467000, ENSP00000503662, ENST00000678960, ENST00000679014, ENST00000264657, ENSG00000168610, ENSP00000384943, ENST00000678906, ENST00000678827, ENST00000588969, ENST00000585517, ENST00000404395, ENSP00000503181, ENSP00000503237, ENST00000677030, ENSP00000503634, ENSP00000264657, ENST00000678044, ENSP00000504184, ENSP00000467985

Pharos - Targets

P40763

Orphanet

16805

ZINC - Predictions - Purchasable

STAT3_HUMAN

Interactors (88)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.919	15
UniProt:P42224 STAT1	8	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.908	10
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.873	10
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.842	8
UniProt:P51813 BMX	3	BMX(1-242) [cytosol] (R-HSA-351899) BMX [cytosol] (R-HSA-351917) BMX(243-675) [cytosol] (R-HSA-351875)	0.83	8
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.83	9
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.775	9
IntAct:EBI-1550784 CDKN1A			0.725	6
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.649	4
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.635	4
UniProt:P30626 SRI	1	SRI [sarcoplasmic reticulum membrane] (R-HSA-5490313)	0.635	3
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.625	5
UniProt:P06401 PGR	3	monoSUMO1-K7,K388,K531-PGR [nucleoplasm] (R-HSA-4341032) PGR [cytosol] (R-HSA-8948964) PGR [nucleoplasm] (R-HSA-3008952)	0.623	3
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.623	2
UniProt:P45984-1 MAPK9			0.602	3
UniProt:Q810M5 ZDH19			0.576	4
UniProt:P23458 JAK1	6	p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335) JAK1 [endosome] (R-HSA-8983168) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.564	2
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.558	4
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q9DUM3 Q9DUM3			0.556	4
UniProt:Q96HA1-2 POM121			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:P12268 IMPDH2	4	IMPDH2 [secretory granule lumen] (R-HSA-6803323) IMPDH2 [extracellular region] (R-HSA-6806455) IMPDH2 [ficolin-1-rich granule lumen] (R-HSA-6803330) IMPDH2 [cytosol] (R-HSA-57350)	0.556	3
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.556	4
UniProt:Q9BXM7 PINK1	5	p-S228,S402-PINK1 [mitochondrial outer membrane] (R-HSA-9834051) PINK1 [mitochondrial outer membrane] (R-HSA-5205653) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628)	0.547	2
UniProt:Q8N6P7 IL22RA1	2	IL22RA1 [plasma membrane] (R-HSA-448489) p-Y-251,p-Y301-IL22RA1 [plasma membrane] (R-HSA-8987198)	0.547	2
IntAct:EBI-9914958 STAT3			0.527	3
IntAct:EBI-1265559 MYC			0.527	3
UniProt:Q14289 PTK2B	3	p-Y-PTK2B [cytosol] (R-HSA-508515) PTK2B [cytosol] (R-HSA-390932) PTK2B [cytosol] (R-HSA-5218721)	0.527	4
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.527	5
UniProt:O75116 ROCK2	2	ROCK2 [cytosol] (R-HSA-419058) Activated ROCK2 [cytosol] (R-HSA-4687775)	0.524	3
UniProt:Q14938-4 NFIX			0.524	3
UniProt:Q14938-3 NFIX			0.524	3
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.512	3
UniProt:Q98PK8 Q98PK8			0.512	3
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.508	2
UniProt:Q9ULD0 OGDHL			0.508	2
UniProt:Q13011 ECH1	3	ECH1 [mitochondrial matrix] (R-HSA-9838037) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.508	2
UniProt:P07384 CAPN1	4	CAPN1 [plasma membrane] (R-HSA-3828038) CAPN1 [cytosol] (R-HSA-3288367) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284)	0.508	2
UniProt:P30084 ECHS1	17	Q159R ECHS1 [mitochondrial matrix] (R-HSA-9916666) F33S ECHS1 [mitochondrial matrix] (R-HSA-9916682) E77Q ECHS1 [mitochondrial matrix] (R-HSA-9916667) A138V ECHS1 [mitochondrial matrix] (R-HSA-9916683) N59S ECHS1 [mitochondrial matrix] (R-HSA-9916684) C225R ECHS1 [mitochondrial matrix] (R-HSA-9916672) ECHS1 [mitochondrial matrix] (R-HSA-54125) A2V ECHS1 [mitochondrial matrix] (R-HSA-9916688) T180A ECHS1 [mitochondrial matrix] (R-HSA-9916687) A238V ECHS1 [mitochondrial matrix] (R-HSA-9916686) A132T ECHS1 [mitochondrial matrix] (R-HSA-9916665) G195S ECHS1 [mitochondrial matrix] (R-HSA-9916681) K273E ECHS1 [mitochondrial matrix] (R-HSA-9916680) R54H ECHS1 [mitochondrial matrix] (R-HSA-9916676) I66T ECHS1 [mitochondrial matrix] (R-HSA-9916659) D150G ECHS1 [mitochondrial matrix] (R-HSA-9916674) A158D ECHS1 [mitochondrial matrix] (R-HSA-9916689)	0.508	3
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.508	2
UniProt:Q96G01 BICD1	1	BICD1 [cytosol] (R-HSA-8848104)	0.508	2
UniProt:Q8TE76 MORC4			0.508	2
UniProt:O14874 BCKDK	5	BCKDK [mitochondrial matrix] (R-HSA-5693129) R224P BCKDK [mitochondrial matrix] (R-HSA-9912466) R174Gfs1* BCKDK [mitochondrial matrix] (R-HSA-9912469) L389P BCKDK [mitochondrial matrix] (R-HSA-9912461) R156* BCKDK [mitochondrial matrix] (R-HSA-9912465)	0.508	2
UniProt:P46781 RPS9	2	RPS9 [nucleoplasm] (R-HSA-6790663) RPS9 [cytosol] (R-HSA-72387)	0.508	2
UniProt:Q06520 SULT2A1	1	SULT2A1 [cytosol] (R-HSA-176559)	0.508	2
UniProt:P22736 NR4A1	2	p-S351-NR4A1 [nucleoplasm] (R-HSA-199846) NR4A1 [nucleoplasm] (R-HSA-199831)	0.508	3
UniProt:P31146 CORO1A	1	CORO1A [cytosol] (R-HSA-9636432)	0.508	2
IntAct:EBI-9825772 C-FOS PROMOTER REGION			0.499	2
IntAct:EBI-10039972 MMP2			0.499	2
UniProt:Q9NWQ8 PAG1	2	PAG1 [plasma membrane] (R-HSA-180500) p-Y317-PAG1 [plasma membrane] (R-HSA-180494)	0.499	7
UniProt:P32119 PRDX2	2	p-T89-PRDX2 [cytosol] (R-HSA-8868574) PRDX2 [cytosol] (R-HSA-3341292)	0.499	4
IntAct:EBI-1108795 NPM			0.499	2
IntAct:EBI-9980755 MIR-155			0.499	2
IntAct:EBI-10952519 STAT			0.499	4
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.499	5
UniProt:Q5VWN6 TASO2			0.488	2
IntAct:EBI-10696506 MPZL1			0.488	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2
UniProt:Q8NEC7 GSTCD			0.488	2
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.488	2
UniProt:P35219 CAH8			0.488	2
UniProt:Q9Y4J8-9 DTNA			0.488	2
UniProt:P27986-2 PIK3R1			0.488	2
UniProt:Q9NVE4 CCD87			0.488	2
UniProt:Q96DZ7 T4S19			0.488	2
UniProt:Q8IZQ1 WDFY3			0.488	2
UniProt:Q6P1L5 F117B			0.488	2
UniProt:Q86WK9 PAQR7			0.488	2
UniProt:Q14847 LASP1			0.488	2
UniProt:Q03181-2 PPARD			0.488	2
UniProt:Q3KNS6 ZN829			0.488	2
UniProt:Q7L591-3 DOK3			0.488	2
UniProt:Q9UBX0 HESX1			0.488	2
UniProt:Q6ZVU3 Q6ZVU3			0.488	2
UniProt:Q9Y2X9 ZN281			0.488	2
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.488	2
UniProt:P49137 MAPKAPK2	5	MAPKAPK2 [cytosol] (R-HSA-187743) p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) MAPKAPK2 [nucleoplasm] (R-HSA-450235)	0.488	2
UniProt:Q9Y3P9 RABGAP1	1	RABGAP1 [cytosol] (R-HSA-8854144)	0.488	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.488	2
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.488	2
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.483	3
UniProt:O95661 DIRA3			0.463	3
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.463	4
UniProt:P35232 PHB	2	PHB [cytosol] (R-HSA-5672944) PHB [mitochondrial inner membrane] (R-HSA-8953720)	0.463	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.462	3
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.462	2
UniProt:Q99062 CSF3R	5	K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane] (R-HSA-9707928) CSF3R [plasma membrane] (R-HSA-6787734) p-4Y-CSF3R [plasma membrane] (R-HSA-9674543) p-4Y-CSF3R [endocytic vesicle membrane] (R-HSA-9705736) K48polyUb-K655,p-4Y-CSF3R [endocytic vesicle membrane] (R-HSA-9705727)	0.462	4

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