IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2

Stable Identifier
R-HSA-8983003
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
IRS1/IRS2 binds IL7R complex
ReviewStatus
5/5
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IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2
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Insulin receptor substrate 1 and 2 (IRS1, IRS2) bind to activated Interleukin-7 receptor complex . Interleukin-7 (IL7) stimulation of human thymocytes results in the rapid tyrosine phosphorylation of IRS1 and IRS2. This is a black box event because the kinase responsible for IRS phosphorylation is unclear.
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Orthologous Events
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Bos taurus)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Canis familiaris)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Gallus gallus)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Mus musculus)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Rattus norvegicus)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Sus scrofa)
Authored
Duenas, C  (2017-07-20)
Reviewed
Kumar, U  (2017-07-26)
Created
Duenas, C  (2017-03-22)
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