Expression of STAT5 upregulated genes

Stable Identifier
R-HSA-8983011
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Expression of STAT5 upregulated genes
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Interleukin-7 (IL7) stimulation upregulates expression of the transcripts and proteins encoding Cytokine-inducible SH2-containing protein (CISH), Suppressor of cytokine signaling 1 (SOCS1) and Suppressor of cytokine signaling 2 (SOCS2) in CD8+ T cells (Ghazawi et al. 2016).
This is a black-box event since details of the mechanism of transcription and translation are omitted.
Literature References
PubMed ID Title Journal Year
27423467 Suppressor of cytokine signaling (SOCS) proteins are induced by IL-7 and target surface CD127 protein for degradation in human CD8 T cells

MacPherson, PA, Faller, EM, El-Salfiti, A, Ghazawi, FM, Parmar, P

Cell. Immunol. 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CISH gene, SOCS1 gene, SOCS2 gene:p-STAT5 dimer [nucleoplasm] (Homo sapiens)
Active Unit
p-STAT5 dimer [nucleoplasm]
Authored
Duenas, C  (2017-07-20)
Reviewed
Kumar, U  (2017-07-26)
Created
Duenas, C  (2017-03-22)
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