Reactome | STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex

STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex

Stable Identifier

R-HSA-8983059

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

TSLP:IL7R:CRLF2 phosphorylates STAT3

ReviewStatus

5/5

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STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex

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Inferred from mouse:
Following binding of TSLP to Cytokine receptor-like factor 2 (CRLF2, TSLPR) and Interleukin-7 receptor subunit alpha (IL7R), Signal transducer and activator of transcription 5A and 5B (STAT5A and STAT5B) and Signal transducer and activator of transcription 3 (STAT3) were phosphorylated in various Ba/F3 cell populations (Reche et al. 2001).
This is a black box event since the kinase responsible for STAT phosphorylation is unknown.

Literature References

PubMed ID	Title	Journal	Year
11418668	Human thymic stromal lymphopoietin preferentially stimulates myeloid cells Reche, PA, Soumelis, V, Gorman, DM, Clifford, T, Liu, MR, Travis, M, Zurawski, SM, Johnston, J, Liu, YJ, Spits, H, de Waal Malefyt, R, Kastelein, RA, Bazan, JF	J. Immunol.	2001