p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex

Stable Identifier
R-HSA-8983078
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex
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Inferred from mouse:
Signal transducer and activator of transcription 5A, 5B (STAT5A and STAT5B) and Signal transducer and activator of transcription 3 (STAT3) are phosphorylated upon addition of human Thymic stromal lymphopoietin (TSLP) when both Cytokine receptor-like factor 2 (CRLF2) and Interleukin-7 Receptor (IL7R) are present (Reche et al. 2001). Subsequently the phosphorylated STATs dissociate.
This is black box event since as not been demonstrated experimentally.
Literature References
PubMed ID Title Journal Year
11418668 Human thymic stromal lymphopoietin preferentially stimulates myeloid cells

Bazan, JF, Johnston, J, Zurawski, SM, de Waal Malefyt, R, Gorman, DM, Liu, MR, Liu, YJ, Clifford, T, Kastelein, RA, Travis, M, Spits, H, Soumelis, V, Reche, PA

J. Immunol. 2001
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as an event of
Orthologous Events
p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Canis familiaris)
Authored
Duenas, C  (2017-07-20)
Reviewed
Kumar, U  (2017-07-26)
Created
Duenas, C  (2017-03-22)
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