Reactome | IL15 binds IL2RB:JAK1 and IL2RG:JAK3

IL15 binds IL2RB:JAK1 and IL2RG:JAK3

Stable Identifier

R-HSA-8983298

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

IL2RB and IL2RG dimerize after IL15 binding, IL2RB:JAK1 and IL2RG:JAK3 dimerize after IL15 binding

ReviewStatus

5/5

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The Interleukin-15 (IL15) / Interleukin-15 receptor subunit alpha (IL15RA, IL15Rα) complex binds Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ), which is associated with Tyrosine-protein kinase JAK3 (JAK3) (Johnston et al. 1995). The heterodimer of IL2RB and IL2RG can bind IL15 with low affinity but high affinity binding requires a third component, IL15RA (Giri et al. 1994, 1995, Anderson et al. 1995). This is a Black Box Event because it is not clear whether the β and γ subunits pre-associate before binding IL15:IL15RA.

Literature References

PubMed ID	Title	Journal	Year
7568001	Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15 Ortaldo, JR, Finbloom, DS, Shibuya, K, Kaplan, D, Giri, JD, Bacon, CM, Chen, YQ, Gupta, S, Johnston, JA, Rees, RC	Proc Natl Acad Sci U S A	1995