Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GRB2 [cytosol]
Stable Identifier
R-HSA-8983328
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9Y2R2 PTPN22
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
FLT3 mutant dimers bind GRB2 (Homo sapiens)
GRB2 [cytosol] (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK fusions bind GRB2 (Homo sapiens)
GRB2 [cytosol] (Homo sapiens)
ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)
GRB2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
GRB2 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)
GRB2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by LTK (Homo sapiens)
IRS1 recruits GRB2 to active LTK (Homo sapiens)
GRB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62993 GRB2
Gene Names
GRB2, ASH
Chain
chain:1-217
Reference Genes
BioGPS Gene:2885 GRB2
COSMIC (genes):GRB2 GRB2
CTD Gene:2885 GRB2
dbSNP Gene:2885 GRB2
ENSEMBL:ENSG00000177885 GRB2
ENSEMBL_homo_sapiens_GENE:ENSG00000177885.15 GRB2
HGNC:4566 GRB2
KEGG Gene (Homo sapiens):2885 GRB2
Monarch:2885 GRB2
NCBI Gene:2885 GRB2
OMIM:108355 GRB2
UCSC:P62993 GRB2
Reference Transcript
RefSeq:NM_002086.4 GRB2
RefSeq:NM_203506.2 GRB2
Other Identifiers
11718334_a_at
11741435_s_at
1565_s_at
16848807
215075_PM_s_at
215075_s_at
223049_PM_at
223049_at
2885
33855_at
3770746
3770747
3770748
3770749
3770750
3770751
3770752
3770753
3770754
3770755
3770756
3770757
3770758
3770761
3770772
3770773
3770774
3770777
3770778
46217_at
8018364
A_23_P77847
A_24_P39654
A_24_P407717
GE78983
GE83126
GO:0001784
GO:0002376
GO:0003723
GO:0005068
GO:0005091
GO:0005154
GO:0005168
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005768
GO:0005794
GO:0005829
GO:0005886
GO:0005911
GO:0005938
GO:0007010
GO:0007165
GO:0007173
GO:0007265
GO:0008180
GO:0008286
GO:0008543
GO:0012506
GO:0014044
GO:0016020
GO:0016192
GO:0017124
GO:0019901
GO:0019903
GO:0019904
GO:0023052
GO:0030036
GO:0030154
GO:0030674
GO:0030838
GO:0031410
GO:0031623
GO:0035987
GO:0042552
GO:0042770
GO:0042802
GO:0043226
GO:0043408
GO:0043560
GO:0046875
GO:0048009
GO:0048646
GO:0048856
GO:0050853
GO:0060090
GO:0060670
GO:0065003
GO:0070062
GO:0070436
GO:0071479
GO:0098772
GO:2000379
HMNXSV003047633
Hs.296381.1.A1_3p_a_at
ILMN_1742521
ILMN_1748797
M96995_s_at
PH_hs_0024870
TC17001877.hg
g12005510_3p_at
Participates
as a component of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
ALK fusion dimers:p-3Y SHC1:GRB2 [cytosol] (Homo sapiens)
ALK fusion dimers:GRB2 [cytosol] (Homo sapiens)
GRB2:TNK2 [cytosol] (Homo sapiens)
GRB2:SOS1 [cytosol] (Homo sapiens)
Active LTK:p-Y IRS1:GRB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2 [plasma membrane] (Homo sapiens)
p-6Y FLT3 ITD mutant dimers:GRB2:p-Y GAB2:PTPN11 [plasma membrane] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
as an input of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)
ALK fusions bind GRB2 (Homo sapiens)
IRS1 recruits GRB2 to active LTK (Homo sapiens)
FLT3 mutant dimers bind GRB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)
Inferred To
Grb2 [cytosol]
(Mus musculus)
Grb2 [cytosol]
(Rattus norvegicus)
grb2 [cytosol]
(Xenopus tropicalis)
GRB2 [cytosol]
(Bos taurus)
GRB2 [cytosol]
(Canis familiaris)
GRB2 [cytosol]
(Gallus gallus)
GRB2 [cytosol]
(Sus scrofa)
drk [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_987102.1
,
NP_002077.1
OpenTargets
ENSG00000177885
HPA
ENSG00000177885-GRB2
GeneCards
P62993
ZINC - Substances
GRB2_HUMAN
ZINC target
P62993
Ensembl
ENSG00000177885
,
ENST00000316804
,
ENST00000648046
,
ENST00000316615
,
ENSP00000376347
,
ENSP00000339007
,
ENST00000392563
,
ENST00000392564
,
ENSP00000376346
,
ENSP00000317360
,
ENST00000392562
,
ENSP00000376345
,
ENSP00000496913
PRO
P62993
Pharos - Targets
P62993
ZINC - Predictions - Purchasable
GRB2_HUMAN
PDB
3OV1
,
3N7Y
,
2VWF
,
1GFC
,
6SDF
,
1GFD
,
3WA4
,
2AOB
,
2H46
,
3C7I
,
3IMJ
,
3MXC
,
1BMB
,
1TZE
,
3IMD
,
1JYQ
,
2VVK
,
3KFJ
,
3S8N
,
6WM1
,
1QG1
,
1GHU
,
4P9Z
,
1CJ1
,
6ICH
,
2W0Z
,
2AOA
,
8DGO
,
1FYR
,
6ICG
,
7MPH
,
3IN8
,
2H5K
,
6WO2
,
1GRI
,
1ZFP
,
1JYR
,
1AZE
,
3N84
,
4P9V
,
5CDW
,
3OVE
,
1FHS
,
1GCQ
,
1JYU
,
1X0N
,
3S8L
,
3MXY
,
1IO6
,
2HUW
,
3N8M
,
3IN7
,
6VK2
,
3S8O
,
1BM2
Interactors (262)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.983
59
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.976
33
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.972
29
UniProt:Q13191 CBLB
1
CBLB [cytosol]
(R-HSA-976009)
0.967
30
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.963
19
UniProt:Q9UQC2 GAB2
5
p-Y643-GAB2 [cytosol]
(R-HSA-9677149)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
p-Y-GAB2 [cytosol]
(R-HSA-912529)
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
GAB2 [cytosol]
(R-HSA-508239)
0.953
16
UniProt:Q07890 SOS2
1
SOS2 [cytosol]
(R-HSA-167221)
0.939
13
UniProt:O00401 WASL
4
N-WASP [cytosol]
(R-HSA-201873)
p-Y256-WASL [cytosol]
(R-HSA-2197672)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.935
12
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.934
16
UniProt:Q9UJM3 ERRFI
0.934
18
UniProt:Q9H706 GARE1
0.933
13
UniProt:P11274 BCR
4
BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838979)
p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1839041)
BCR(1-584)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1604524)
BCR [cytosol]
(R-HSA-195200)
0.928
13
UniProt:Q13480 GAB1
4
GAB1 [cytosol]
(R-HSA-179795)
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
p-Y-GAB1 [cytosol]
(R-HSA-8855306)
0.927
13
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.926
10
UniProt:P50570 DNM2
5
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [plasma membrane]
(R-HSA-2984201)
0.926
10
UniProt:Q13094 LCP2
2
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
LCP2 [cytosol]
(R-HSA-202306)
0.918
18
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.916
8
UniProt:Q9ULH1 ASAP1
1
ASAP1 [cytosol]
(R-HSA-5620905)
0.906
12
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.905
11
UniProt:Q9Y4K4 M4K5
0.897
7
UniProt:Q05193 DNM1
3
DNM1 [cytosol]
(R-HSA-2213182)
DNM1 [lysosomal membrane]
(R-HSA-196150)
DNM1 [plasma membrane]
(R-HSA-177488)
0.87
8
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.868
8
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.863
6
UniProt:Q8TF74 WIPF2
1
WIPF2 [cytosol]
(R-HSA-2197666)
0.85
7
UniProt:Q9UKW4 VAV3
2
VAV3 [cytosol]
(R-HSA-430152)
p-Y173-VAV3 [cytosol]
(R-HSA-442287)
0.848
8
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.848
10
UniProt:Q9H3S7 PTPN23
1
PTPN23 [nucleoplasm]
(R-HSA-9008924)
0.834
8
UniProt:Q12774 ARHGEF5
1
ARHGEF5 [cytosol]
(R-HSA-8873909)
0.82
8
UniProt:P35235 Ptpn11
5
p-Y546,Y584-Shp2 [cytosol]
(R-MMU-443116)
Ptpn11 [cytosol]
(R-MMU-210002)
PTPN11 [nucleoplasm]
(R-MMU-8937745)
PTPN11 [cytosol]
(R-MMU-162563)
phospho-p-Y542,Y580-PTPN11 [cytosol]
(R-MMU-162573)
0.809
7
UniProt:Q14185 DOCK1
1
DOCK1 [cytosol]
(R-HSA-372654)
0.809
6
UniProt:O43516 WIPF1
1
WIPF1 [cytosol]
(R-HSA-201874)
0.804
5
UniProt:O00750 PIK3C2B
1
PIK3C2B [cytosol]
(R-HSA-1604619)
0.802
6
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA M1043I [cytosol]
(R-HSA-1500719)
PIK3CA M1043T [cytosol]
(R-HSA-2395934)
PIK3CA M1043V [cytosol]
(R-HSA-2395932)
PIK3CA H1047Y [cytosol]
(R-HSA-1500720)
PIK3CA E542K [cytosol]
(R-HSA-1500701)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
0.8
6
UniProt:Q6ZUJ8 PIK3AP1
1
p-4Y-PIK3AP1 [plasma membrane]
(R-HSA-984814)
0.798
6
UniProt:Q9UKT9 IKZF3
0.795
8
UniProt:Q8N1K5 THMS1
0.794
11
UniProt:Q92918 M4K1
0.782
9
UniProt:O43150 ASAP2
0.752
4
UniProt:Q8WV28 BLNK
2
BLNK [cytosol]
(R-HSA-912750)
p-5Y-BLNK [plasma membrane]
(R-HSA-983579)
0.743
5
UniProt:P10721 KIT
20
KIT C443Y [plasma membrane]
(R-HSA-9680045)
KIT T417_D419delinsY [plasma membrane]
(R-HSA-9680110)
KIT S476I [plasma membrane]
(R-HSA-9680090)
KIT K509I [plasma membrane]
(R-HSA-9680177)
KIT D419A [plasma membrane]
(R-HSA-9680051)
KIT D419del [plasma membrane]
(R-HSA-9680079)
KIT S501_A502dup [plasma membrane]
(R-HSA-9680105)
KIT D419G [plasma membrane]
(R-HSA-9680057)
KIT N505_F508dup [plasma membrane]
(R-HSA-9680085)
KIT C443S [plasma membrane]
(R-HSA-9680038)
KIT D419N [plasma membrane]
(R-HSA-9680071)
KIT S476N [plasma membrane]
(R-HSA-9680097)
KIT D419H [plasma membrane]
(R-HSA-9680066)
KIT V560_L576del [plasma membrane]
(R-HSA-9670336)
KIT Y823N [plasma membrane]
(R-HSA-9669591)
KIT Y823C [plasma membrane]
(R-HSA-9669585)
p6Y-KIT Y823D [plasma membrane]
(R-HSA-9669628)
p7Y-KIT D816V [plasma membrane]
(R-HSA-9669612)
p7Y-KIT K642E [plasma membrane]
(R-HSA-9669596)
p7Y-KIT N822K [plasma membrane]
(R-HSA-9669617)
0.743
6
UniProt:Q8IUW3 SPA2L
0.742
5
UniProt:Q8N1I0 DOCK4
1
DOCK4 [cytosol]
(R-HSA-1012995)
0.738
5
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.738
5
UniProt:P35570 Irs1
7
Irs1 [cytosol]
(R-RNO-1168867)
phospho-Irs1 [plasma membrane]
(R-RNO-2445090)
Irs1 [plasma membrane]
(R-RNO-2425392)
p-Y-Irs1 [cytosol]
(R-RNO-112362)
Irs1 [cytosol]
(R-RNO-74769)
phospho-Irs1 [cytosol]
(R-RNO-74772)
phospho-Irs1 [plasma membrane]
(R-RNO-198366)
0.737
5
UniProt:Q07912 TNK2
1
TNK2 [cytosol]
(R-HSA-9842568)
0.737
5
UniProt:P21802 FGFR2
20
FGFR2 IIIa TM [extracellular region]
(R-HSA-8851703)
FGFR2 [plasma membrane]
(R-HSA-2023840)
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853137)
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
(R-HSA-8853154)
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853123)
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
(R-HSA-8853158)
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
(R-HSA-8853150)
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
(R-HSA-8853153)
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
(R-HSA-8853139)
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
(R-HSA-8853159)
FGFR2 N549H [plasma membrane]
(R-HSA-2033296)
FGFR2 N549K [plasma membrane]
(R-HSA-1637910)
FGFR2 K660N [plasma membrane]
(R-HSA-1637905)
FGFR2 K660M [plasma membrane]
(R-HSA-1637902)
FGFR2 K660E [plasma membrane]
(R-HSA-1637900)
FGFR2 S267P [plasma membrane]
(R-HSA-1637920)
FGFR2 L764Hfs*4 [plasma membrane]
(R-HSA-1637908)
FGFR2 W290C [plasma membrane]
(R-HSA-1637929)
p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853134)
p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853146)
0.735
6
UniProt:Q96P48 ARAP1
2
ARAP1 [cytosol]
(R-HSA-3211582)
p-Y231-ARAP1 [cytosol]
(R-HSA-8848869)
0.725
5
UniProt:A6NGB9 WIPF3
1
WIPF3 [cytosol]
(R-HSA-2197670)
0.725
5
UniProt:Q96JJ3 ELMO2
1
ELMO2 [cytosol]
(R-HSA-372642)
0.725
5
UniProt:B7ZLH0 B7ZLH0
0.718
6
UniProt:Q13444 ADAM15
1
ADAM15 [plasma membrane]
(R-HSA-708329)
0.713
4
UniProt:Q14457 BECN1
4
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.709
8
UniProt:O43561 LAT
3
p-Y200,Y220-LAT [plasma membrane]
(R-HSA-434829)
p-5Y-LAT [plasma membrane]
(R-HSA-202364)
LAT [plasma membrane]
(R-HSA-202322)
0.708
7
UniProt:Q62245 Sos1
4
phospho-Sos1 [cytosol]
(R-MMU-109821)
Sos1 [cytosol]
(R-MMU-443318)
Sos1 [plasma membrane]
(R-MMU-983559)
Sos1 [cytosol]
(R-MMU-64847)
0.704
4
UniProt:Q08209 PPP3CA
2
PPP3CA [nucleoplasm]
(R-HSA-2685599)
PPP3CA [cytosol]
(R-HSA-201771)
0.678
3
UniProt:P21860 ERBB3
0.678
5
UniProt:Q9H204 MED28
1
MED28 [nucleoplasm]
(R-HSA-6804546)
0.676
3
UniProt:Q16643 DBN1
1
DBN1 [cytosol]
(R-HSA-9714666)
0.674
4
UniProt:P11137 MTAP2
0.672
7
UniProt:O60636 TSN2
0.672
6
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.666
4
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.666
4
UniProt:Q9H788 SH24A
0.666
4
UniProt:Q0VD86 INCA1
0.666
4
UniProt:Q9Y2W2 WBP11
1
WBP11 [nucleoplasm]
(R-HSA-8867887)
0.666
4
UniProt:Q06418 TYRO3
0.666
4
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.666
4
UniProt:Q15427 SF3B4
1
SF3B4 [nucleoplasm]
(R-HSA-71975)
0.665
3
UniProt:P15498 VAV1
5
p-Y-VAV1 [cytosol]
(R-HSA-9029087)
VAV1 [plasma membrane]
(R-HSA-1045153)
VAV1 [cytosol]
(R-HSA-195066)
p-Y174-VAV1 [cytosol]
(R-HSA-437946)
p-Y142,Y160,Y174-VAV1 [plasma membrane]
(R-HSA-389323)
0.665
3
UniProt:P98078
3
Dab2 [cytosol]
(R-MMU-8862456)
Dab2 [lysosomal membrane]
(R-MMU-2980807)
Dab2 [plasma membrane]
(R-MMU-2980808)
0.662
4
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.659
3
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.659
4
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.659
4
UniProt:Q05397 PTK2
11
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.659
4
UniProt:O00459 PIK3R2
3
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
p-Y464-PIK3R2 [cytosol]
(R-HSA-9860512)
0.659
4
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.659
3
UniProt:Q13905 RAPGEF1
2
RAPGEF1 [cytosol]
(R-HSA-913472)
RAPGEF1 [endosome]
(R-HSA-3008667)
0.658
3
UniProt:P27958 POLG
1
POLG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HCV-8854138)
0.656
3
UniProt:P29350 PTPN6
5
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.646
3
UniProt:Q9UQ16 DNM3
2
DNM3 [cytosol]
(R-HSA-2213188)
DNM3 [plasma membrane]
(R-HSA-443610)
0.643
4
UniProt:Q9H7D0 DOCK5
1
DOCK5 [cytosol]
(R-HSA-1012991)
0.643
4
UniProt:P23469 PTPRE
0.643
3
UniProt:Q9H9H4 VPS37B
1
VPS37B [endosome membrane]
(R-HSA-184293)
0.643
4
UniProt:P42338 PIK3CB
1
PIK3CB [cytosol]
(R-HSA-74788)
0.643
3
UniProt:Q9H792 PEAK1
1
PEAK1 [cytosol]
(R-HSA-9715162)
0.643
3
UniProt:O43426 SYNJ1
1
SYNJ1 [cytosol]
(R-HSA-1604634)
0.643
3
UniProt:Q75VX8 GARE2
0.643
3
UniProt:Q38SD2 LRRK1
0.643
3
UniProt:Q14247 CTTN
2
CTTN [cytosol]
(R-HSA-201894)
p-S113-CTTN [cytosol]
(R-HSA-442842)
0.643
3
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.642
4
UniProt:Q8N1K5-1 THEMIS
0.639
10
UniProt:O14939 PLD2
2
PLD2 [plasma membrane]
(R-HSA-2029075)
PLD2 [endoplasmic reticulum membrane]
(R-HSA-1498791)
0.635
4
UniProt:Q15027 ACAP1
0.635
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.615
4
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.61
4
UniProt:O14672 ADAM10
6
ADAM10(215-824) [plasma membrane]
(R-HSA-179885)
ADAM10 [plasma membrane]
(R-HSA-157237)
ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956768)
p-ADAM10 [endoplasmic reticulum lumen]
(R-HSA-8956999)
ADAM10 [tertiary granule membrane]
(R-HSA-6800992)
ADAM10 [specific granule membrane]
(R-HSA-6799566)
0.602
5
UniProt:Q8NFH8 REPS2
1
REPS2 [cytosol]
(R-HSA-432938)
0.602
8
UniProt:P30530 AXL
2
p-Y779,Y821-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
0.597
4
UniProt:P34152 Ptk2
13
phospho-pY-PTK2 [cytosol]
(R-MMU-9632393)
phospho-p-6Y-PTK2 [cytosol]
(R-MMU-354128)
phospho-p-Y397-PTK2 [cytosol]
(R-MMU-354068)
PTK2 [cytosol]
(R-MMU-201621)
PTK2(1-772) [cytosol]
(R-MMU-202827)
PTK2(773-1052) [cytosol]
(R-MMU-202829)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-MMU-5218694)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-MMU-5229006)
phospho-p-5Y-PTK2 [cytosol]
(R-MMU-5218711)
Fak1 [cytosol]
(R-MMU-3928448)
p-Y428-FAK1 [cytosol]
(R-MMU-3928397)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-MMU-8874600)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-MMU-8874613)
0.597
3
UniProt:O15357 INPPL1
1
INPPL1 [cytosol]
(R-HSA-913354)
0.597
4
UniProt:Q9ESJ4
1
Nckipsd [cytosol]
(R-MMU-2197671)
0.593
8
UniProt:Q5SQ64 LY6G6F
2
LY6G6F [plasma membrane]
(R-HSA-8862974)
LY6G6F [platelet alpha granule membrane]
(R-HSA-8862968)
0.591
3
UniProt:O43597 SPRY2
8
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
SPRY2 [plasma membrane]
(R-HSA-182924)
SPRY2 [cytosol]
(R-HSA-182949)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
0.591
3
UniProt:O92972 POLG
0.589
2
UniProt:Q15303 ERBB4
0.573
7
UniProt:O14490 DLGAP1
1
DLGAP1 [plasma membrane]
(R-HSA-6794239)
0.573
3
UniProt:Q9BYB0 SHANK3
1
SHANK3 [cytosol]
(R-HSA-6794277)
0.573
2
UniProt:Q8IVH8 M4K3
0.573
2
UniProt:O15056 SYNJ2
1
SYNJ2 [cytosol]
(R-HSA-1806193)
0.573
2
UniProt:P98082 DAB2
3
DAB2 [cytosol]
(R-HSA-8862456)
DAB2 [lysosomal membrane]
(R-HSA-2980807)
DAB2 [plasma membrane]
(R-HSA-2980808)
0.573
2
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.57
3
UniProt:Q8WXH5 SOCS4
1
SOCS4 [cytosol]
(R-HSA-8936109)
0.57
3
UniProt:Q8TE12 LMX1A
0.57
3
UniProt:Q5BJH2-2 TMEM128
0.57
3
UniProt:Q07869 PPARA
2
monoSUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
PPARA [nucleoplasm]
(R-HSA-400186)
0.57
3
UniProt:Q9NPB6-2 PARD6A
0.57
3
UniProt:P14868 DARS1
1
DARS [cytosol]
(R-HSA-379605)
0.564
2
UniProt:P21333 FLNA
3
FLNA [extracellular region]
(R-HSA-350712)
p-S2152-FLNA [cytosol]
(R-HSA-5669246)
FLNA [cytosol]
(R-HSA-210019)
0.564
2
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.564
2
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.564
2
UniProt:O75369 FLNB
1
FLNB [cytosol]
(R-HSA-354163)
0.564
2
UniProt:Q9H0X6 RN208
0.556
3
UniProt:Q9BWF3-2 RBM4
0.556
3
UniProt:Q9NRF2-2 SH2B1
1
SH2B1-2 [cytosol]
(R-HSA-1675482)
0.556
3
UniProt:Q7Z783 Q7Z783
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q13829 TNFAIP1
1
TNFAIP1 [cytosol]
(R-HSA-9696531)
0.556
3
UniProt:Q14693 LPIN1
3
p-S106-LPIN1 [nucleoplasm]
(R-HSA-4419936)
LPIN1 [nuclear envelope]
(R-HSA-4419927)
LPIN1 [endoplasmic reticulum membrane]
(R-HSA-549157)
0.556
3
UniProt:Q6P1W5 CA094
0.556
3
UniProt:Q9P2A4 ABI3
0.556
3
UniProt:Q13352 ITGB3BP
2
ITGB3BP [cytosol]
(R-HSA-3006405)
ITGB3BP [nucleoplasm]
(R-HSA-606325)
0.556
3
UniProt:Q9NQC1-2 JADE2
0.556
3
UniProt:Q9UI10 EIF2B4
1
EIF2B4 [cytosol]
(R-HSA-72521)
0.556
3
UniProt:A5D8V6 VPS37C
1
VPS37C [endosome membrane]
(R-HSA-184438)
0.556
3
UniProt:Q15428 SF3A2
1
SF3A2 [nucleoplasm]
(R-HSA-71964)
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:P52566 ARHGDIB
1
ARHGDIB [cytosol]
(R-HSA-195081)
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q9BUN5-3 CCDC28B
0.556
3
UniProt:Q12929 EPS8
1
EPS8 [cytosol]
(R-HSA-9662382)
0.556
3
UniProt:Q86UU5 GGN
0.556
3
UniProt:Q9BYN7 ZN341
0.556
3
UniProt:Q3LI72 KRTAP19-5
1
KRTAP19-5 [cytosol]
(R-HSA-6810300)
0.556
3
UniProt:Q6DHY5 TBC3G
0.556
3
UniProt:Q96RU7 TRIB3
3
TRIB3 [plasma membrane]
(R-HSA-199447)
TRIB3 [cytosol]
(R-HSA-162411)
TRIB3 [nucleoplasm]
(R-HSA-9635877)
0.556
3
UniProt:P25791 LMO2
1
LMO2 [nucleoplasm]
(R-HSA-8956513)
0.556
3
UniProt:Q8NFB2 T185A
0.556
3
UniProt:Q8IX15-3 HOMEZ
0.556
3
UniProt:Q6XD76 ASCL4
0.556
3
UniProt:P42681 TXK
3
TXK [cytosol]
(R-HSA-3448733)
p-Y91,Y420-TXK [cytosol]
(R-HSA-3448740)
p-Y420-TXK [cytosol]
(R-HSA-3448734)
0.556
3
UniProt:O95994 AGR2
0.556
5
UniProt:A0JLT2-2 MED19
0.556
3
UniProt:Q92558 WASF1
3
WASF1 [cytosol]
(R-HSA-200965)
p-Y151,S,T-WASF1 [cytosol]
(R-HSA-5672390)
p-Y151-WASF1 [cytosol]
(R-HSA-2029058)
0.556
3
UniProt:Q7L190 DPPA4
1
DPPA4 [nucleoplasm]
(R-HSA-452999)
0.556
3
UniProt:Q6ZU52 K0408
0.556
3
UniProt:Q8N4B1-4 PHETA1
0.556
3
UniProt:Q03989 ARI5A
0.556
3
UniProt:P27986-2 PIK3R1
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q6ZNG0 ZNF620
1
ZNF620 [nucleoplasm]
(R-HSA-2127603)
0.556
3
UniProt:Q9Y330 ZBT12
0.556
5
UniProt:Q6IQ23-2 PLEKHA7
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
3
UniProt:Q8N9I9 DTX3
0.556
3
UniProt:Q86SG2 ANR23
0.556
3
UniProt:Q9BRR9 ARHGAP9
3
ARHGAP9 [cytosol]
(R-HSA-2976572)
ARHGAP9 [extracellular region]
(R-HSA-6806529)
ARHGAP9 [secretory granule lumen]
(R-HSA-6804973)
0.556
3
UniProt:Q9HB07 MYG1
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:Q9BRT8 ZNG1A
0.556
3
UniProt:Q9GZT8 NIF3L
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:A8MW99 MEI4
0.556
3
UniProt:B1AHC3 B1AHC3
0.556
3
UniProt:Q8N684-3 CPSF7
0.556
3
IntAct:EBI-22412087 CCSB ORF ID
0.556
3
IntAct:EBI-10220116 163154
0.556
3
IntAct:EBI-10178797 4005
0.556
3
UniProt:Q9UNY5 ZN232
0.556
3
UniProt:Q6S9Z5 ZN474
0.556
3
UniProt:P62324 BTG1
1
BTG1 [nucleoplasm]
(R-HSA-9620886)
0.556
3
UniProt:Q96PV4 PNMA5
0.556
3
UniProt:O14512 SOCS7
0.556
3
UniProt:Q13625-3 TP53BP2
0.556
3
UniProt:Q13322-4 GRB10
0.556
3
UniProt:Q5JST6 EFHC2
0.556
3
UniProt:O15156 ZBT7B
0.556
3
UniProt:Q15907 RAB11B
3
RAB11B [recycling endosome membrane]
(R-HSA-8854762)
GGC-RAB11B [cytosol]
(R-HSA-8873766)
RAB11B [cytosol]
(R-HSA-8873671)
0.556
3
UniProt:Q92841 DDX17
2
DDX17 [nucleoplasm]
(R-HSA-3900090)
monoSUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
0.556
3
UniProt:P48634 PRC2A
0.553
2
UniProt:Q8WUM4 PDCD6IP
1
PDCD6IP [cytosol]
(R-HSA-917717)
0.553
2
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.553
2
UniProt:Q5JSH3 WDR44
0.547
2
UniProt:P19338 NCL
3
NCL [plasma membrane]
(R-HSA-9836466)
NCL [macropinosome membrane]
(R-HSA-9837666)
NCL [nucleoplasm]
(R-HSA-6791213)
0.547
2
UniProt:Q01082 SPTBN1
3
SPTBN1(2-159)-FLT3(570-993) fusion [cytosol]
(R-HSA-9703316)
SPTBN1(2-159)-p-6Y-FLT3(570-993) fusion [cytosol]
(R-HSA-9703317)
SPTBN1 [cytosol]
(R-HSA-420048)
0.547
2
UniProt:P05787 KRT8
1
KRT8 [cytosol]
(R-HSA-446043)
0.547
3
UniProt:Q92734 TFG
7
TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9702019)
TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9702038)
TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol]
(R-HSA-9702029)
TFG(1-193)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699887)
TFG(1-138)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699874)
TFG(1-240)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699806)
TFG [cytosol]
(R-HSA-5688159)
0.547
2
UniProt:O75083 WDR1
2
WDR1 [extracellular region]
(R-HSA-350752)
WDR1 [cytosol]
(R-HSA-350699)
0.547
2
UniProt:Q06187 BTK
6
p-Y223,Y551-BTK [cytosol]
(R-HSA-2424454)
Active BTK [cytosol]
(R-HSA-8964323)
p-Y551-BTK [cytosol]
(R-HSA-2685603)
BTK [cytosol]
(R-HSA-197948)
p-Y551-BTK [plasma membrane]
(R-HSA-9606165)
p-Y223,Y551-BTK [plasma membrane]
(R-HSA-984807)
0.547
2
UniProt:O43295 SRGAP3
1
SRGAP3 [cytosol]
(R-HSA-428463)
0.544
2
UniProt:Q9Y2R2 PTPN22
1
PTPN22 [cytosol]
(R-HSA-8852205)
0.544
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.527
3
UniProt:P14618 PKM
3
PKM [secretory granule lumen]
(R-HSA-6801401)
PKM [extracellular region]
(R-HSA-6806491)
PKM [ficolin-1-rich granule lumen]
(R-HSA-6801387)
0.527
2
UniProt:Q9UQ16-2 DNM3
0.527
2
UniProt:P62937 PPIA
5
PPIA [extracellular exosome]
(R-HSA-6801538)
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [extracellular region]
(R-HSA-173646)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [cytosol]
(R-HSA-173123)
0.527
2
UniProt:Q99816 TSG101
1
TSG101 [endosome membrane]
(R-HSA-2980549)
0.527
3
UniProt:Q9UK41 VPS28
1
VPS28 [endosome membrane]
(R-HSA-184342)
0.527
2
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.527
2
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.527
2
UniProt:P05141 SLC25A5
1
SLC25A5 [mitochondrial inner membrane]
(R-HSA-49743)
0.527
3
UniProt:P27708 CAD
1
CAD [cytosol]
(R-HSA-73452)
0.527
3
UniProt:P41240 CSK
2
CSK [plasma membrane]
(R-HSA-180499)
CSK [cytosol]
(R-HSA-203776)
0.527
2
UniProt:O95789 ZMYM6
0.527
2
UniProt:P12236 SLC25A6
2
SLC25A6 [mitochondrial inner membrane]
(R-HSA-49745)
SLC25A6 [mitochondrial intermembrane space]
(R-HSA-1955374)
0.527
2
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
3
UniProt:Q93079 H2BC9
9
Ub-HIST1H2BH [nucleoplasm]
(R-HSA-6782558)
AcK-HIST1H2BH [nucleoplasm]
(R-HSA-4549241)
HIST1H2BH [extracellular region]
(R-HSA-977580)
AcK16-HIST1H2BH [nucleoplasm]
(R-HSA-4568682)
AcK6-HIST1H2BH [nucleoplasm]
(R-HSA-4568718)
AcK21-HIST1H2BH [nucleoplasm]
(R-HSA-4568657)
AcK13-HIST1H2BH [nucleoplasm]
(R-HSA-4568705)
Ub-121-HIST1H2BH [nucleoplasm]
(R-HSA-3364021)
HIST1H2BH [nucleoplasm]
(R-HSA-181915)
0.527
2
UniProt:Q96EY5 MVB12A
1
MVB12A [endosome membrane]
(R-HSA-8955360)
0.527
2
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
0.527
2
UniProt:Q9NZQ3 NCKIPSD
1
NCKIPSD [cytosol]
(R-HSA-2197671)
0.527
2
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.527
3
UniProt:P19105 MYL12A
2
p-S19-MYL12A [cytosol]
(R-HSA-390749)
MYL12A [cytosol]
(R-HSA-390735)
0.527
2
UniProt:Q8TF42 UBS3B
0.527
3
UniProt:Q00325 S25A3
0.527
2
UniProt:P52952 NKX2-5
1
NKX2-5 [nucleoplasm]
(R-HSA-4005994)
0.527
2
UniProt:Q96RF0 SNX18
1
SNX18 [cytosol]
(R-HSA-8868038)
0.527
2
UniProt:Q96RF0-2 SNX18
0.527
2
UniProt:A5YM69 ARHGEF35
1
ARHGEF35 [cytosol]
(R-HSA-8871615)
0.527
3
UniProt:Q13480-2 GAB1
0.527
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.527
3
UniProt:Q9H939 PPIP2
0.527
2
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.527
2
UniProt:P13639 EEF2
10
EEF2 [ficolin-1-rich granule lumen]
(R-HSA-6801513)
EEF2 [extracellular region]
(R-HSA-6806499)
EEF2 [secretory granule lumen]
(R-HSA-6801504)
EEF2 [cytosol]
(R-HSA-156901)
aminocarboxypropyl EEF2 [cytosol]
(R-HSA-5358478)
Me-diphthine EEF2 [cytosol]
(R-HSA-5367025)
nascent EEF2 [cytosol]
(R-HSA-5358472)
diphthine EEF2 [cytosol]
(R-HSA-5358501)
ADP-ribo-EEF2 [cytosol]
(R-HSA-5334764)
Me3K525-EEF2 [cytosol]
(R-HSA-8932237)
0.527
2
UniProt:P07355 ANXA2
6
ANXA2 [cytosol]
(R-HSA-5263667)
ANXA2 [external side of plasma membrane]
(R-HSA-5336164)
p-Y24,S26-ANXA2 [cytosol]
(R-HSA-9865224)
p-S26-ANXA2 [cytosol]
(R-HSA-9865163)
ANXA2 [extracellular region]
(R-HSA-6806242)
ANXA2 [azurophil granule lumen]
(R-HSA-6798766)
0.527
2
UniProt:P29353-1 SHC1
4
SHC1 [plasma membrane]
(R-HSA-2404179)
SHC1-1 [cytosol]
(R-HSA-1433366)
p-S139,3Y-SHC1-1 [cytosol]
(R-HSA-8934452)
p-Y349,Y350,Y427-SHC1-1 [cytosol]
(R-HSA-2404176)
0.524
3
UniProt:P26662-PRO_0000037647
0.524
3
UniProt:O75674 TM1L1
0.524
2
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.524
2
UniProt:Q7L0Q8 RHOU
4
p-Y254-RHOU [endosome membrane]
(R-HSA-9726860)
p-Y254-RHOU [plasma membrane]
(R-HSA-9726857)
RHOU [plasma membrane]
(R-HSA-194914)
RHOU [cytosol]
(R-HSA-194901)
0.524
3
UniProt:Q5SXH7-1 PLEKHS1
0.508
2
UniProt:Q66PJ3-4 ARL6IP4
0.508
2
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.508
2
UniProt:Q9Y478 PRKAB1
2
PRKAB1 [cytosol]
(R-HSA-380968)
PRKAB1 [nucleoplasm]
(R-HSA-2151199)
0.508
2
UniProt:P54762 EPHB1
6
EPHB1 (?-?) [plasma membrane]
(R-HSA-3928449)
EPHB1 (?-984) [cytosol]
(R-HSA-3928438)
EPHB1 (?-984) [plasma membrane]
(R-HSA-3928402)
EPHB1 (18-?) [extracellular region]
(R-HSA-3928393)
p-Y594,Y600-EPHB1 [plasma membrane]
(R-HSA-3928347)
EPHB1 [plasma membrane]
(R-HSA-2682340)
0.499
2
UniProt:Q810M5 ZDH19
0.499
2
UniProt:Q7VLE8 Q7VLE8
0.499
2
UniProt:Q8N7B6-2 PACRGL
0.488
2
UniProt:Q9H7T9 AUNIP
0.488
2
UniProt:Q96D37 Q96D37
0.488
2
UniProt:Q5T749 KPRP
1
KPRP [cytosol]
(R-HSA-9839614)
0.488
2
UniProt:Q9NP98 MYOZ1
0.488
2
UniProt:Q9Y5E4 PCDB5
0.488
2
UniProt:Q96ID7 Q96ID7
0.488
2
UniProt:Q9BRT2 UQCC2
1
UQCC2 [mitochondrial inner membrane]
(R-HSA-9865900)
0.488
2
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.488
2
UniProt:Q8IZQ1 WDFY3
0.488
2
UniProt:Q96SW2-2 CRBN
0.488
2
UniProt:Q8N448 LNX2
0.488
2
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.483
2
UniProt:P09619 PDGFRB
3
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.462
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.462
3
UniProt:P12497-PRO_0000042399 GAG-POL
0.462
3
UniProt:A9UF07 A9UF07
0.462
6
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text