Reactome | JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated

JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated

Stable Identifier

R-HSA-8983834

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated

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Interleukin 35 (IL35) may presumably signal via a complex that includes Tyrosine protein kinase JAK1 (JAK1) and JAK2 associated with Interleukin 6 receptor beta subunit (IL6ST) dimers (Collison et al. 2012). These JAKs are believed to phosphorylate Signal transducer and activator of transcription 1 (STAT) (Stark GR and Darnell JE, 2012). As the series of events that induces JAK/STAT phosphorylation events in response to IL35 are not clear, this event is represented as a black box.

Literature References

PubMed ID	Title	Journal	Year
22306691	The composition and signaling of the IL-35 receptor are unconventional Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM	Nat. Immunol.	2012