Interleukin-35 Signalling

Stable Identifier
R-HSA-8984722
DOI
10.3180/R-HSA-8984722.2
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Interleukin-35 Signalling
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Interleukin 35 (IL35) is an IL12 family cytokine produced by regulatory but not effector T-cells. It is a dimeric protein composed of IL-12RB2 and IL27RA chains. IL35 suppresses inflammatory responses of immune cells.
Literature References
PubMed ID Title Journal Year
26279360 Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases

Yu, CR, Wang, R, Egwuagu, CE, Sun, L

Cytokine Growth Factor Rev. 2015
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Events
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as an event of
Event Information
Go Biological Process
interleukin-35-mediated signaling pathway (0070757)
Orthologous Events
Interleukin-35 Signalling (Bos taurus)
Interleukin-35 Signalling (Caenorhabditis elegans)
Interleukin-35 Signalling (Canis familiaris)
Interleukin-35 Signalling (Dictyostelium discoideum)
Interleukin-35 Signalling (Drosophila melanogaster)
Interleukin-35 Signalling (Gallus gallus)
Interleukin-35 Signalling (Mus musculus)
Interleukin-35 Signalling (Rattus norvegicus)
Interleukin-35 Signalling (Sus scrofa)
Interleukin-35 Signalling (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Jupe, S  (2009-11-25)
Reviewed
Tanaka, M  (2015-11-09)
Narazaki, M  (2015-11-09)
Created
Varusai, TM  (2017-04-10)
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