IL12A gene transcription and translation

Stable Identifier
R-HSA-8984964
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Interleukin-35 (IL35) is a complex conformed by Interleukin-12 subunit alpha (IL12A) and Interleukin-27 subunit alpha (IL27). IL35 can induce heterodimers of Interleukin-6 receptor beta precursor (IL6ST) and Interleukin-12 receptor beta 2 (IL12RB2). Consequently, heteromeric Signal transducer and activator of transcription 1-alpha/beta (STAT1) and Signal transducer and activator of transcription 4 (STAT4) are phosphorylated. Subsequently, this STAT1:STAT4 complex can translocate into the nucleus and bind to promoter regions of IL12A thereby facilitating the protein expression. Thus, by inducing the expression of itself, a positive feedback regulation is achieved in the IL35 signalling pathway. This is a black box event because the intermediate steps of IL12A transcription/translation are omitted.
Literature References
PubMed ID Title Journal Year
22306691 The composition and signaling of the IL-35 receptor are unconventional

Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM

Nat. Immunol. 2012
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