IL12A gene transcription and translation

Stable Identifier
R-HSA-8984964
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum lumen
ReviewStatus
5/5
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IL12A gene transcription and translation
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Interleukin-35 (IL35) is a complex conformed by Interleukin-12 subunit alpha (IL12A) and Interleukin-27 subunit alpha (IL27). IL35 can induce heterodimers of Interleukin-6 receptor beta precursor (IL6ST) and Interleukin-12 receptor beta 2 (IL12RB2). Consequently, heteromeric Signal transducer and activator of transcription 1-alpha/beta (STAT1) and Signal transducer and activator of transcription 4 (STAT4) are phosphorylated. Subsequently, this STAT1:STAT4 complex can translocate into the nucleus and bind to promoter regions of IL12A thereby facilitating the protein expression. Thus, by inducing the expression of itself, a positive feedback regulation is achieved in the IL35 signalling pathway. This is a black box event because the intermediate steps of IL12A transcription/translation are omitted.
Literature References
PubMed ID Title Journal Year
22306691 The composition and signaling of the IL-35 receptor are unconventional

Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM

Nat. Immunol. 2012
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
p-Y693-STAT4:p-Y701-STAT1:IL12A gene [nucleoplasm] (Homo sapiens)
Authored
Varusai, TM  (2016-12-15)
Reviewed
Pylayeva-Gupta, Y  (2017-08-09)
Singh, K  (2017-07-05)
Created
Varusai, TM  (2017-04-11)
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