Reactome | HSCB(1-30) [mitochondrial matrix]

HSCB(1-30) [mitochondrial matrix]

Stable Identifier

R-HSA-8986120

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

HSCB transit peptide, Iron-sulfur cluster co-chaperone protein HscB, mitochondrial, HSC20_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8IWL3 HSCB

Gene Names

HSCB, DNAJC20, HSC20

Chain

chain:1-235, chain:30-235

Reference Genes

BioGPS Gene:150274 HSCB

COSMIC (genes):HSCB HSCB

CTD Gene:150274 HSCB

dbSNP Gene:150274 HSCB

ENSEMBL:ENSG00000100209 HSCB

HGNC:28913 HSCB

KEGG:hsa:150274 HSCB

Monarch:150274 HSCB

NCBI Gene:150274 HSCB

OMIM:608142 HSCB

UCSC:Q8IWL3 HSCB

Reference Transcript

RefSeq:NM_172002.4 HSCB

Other Identifiers

11728460_at

150274

16928668

223647_3p_x_at

223647_PM_x_at

223647_x_at

3941624

3941625

3941626

3941627

3941630

3941631

3941633

3941635

3941638

3941641

3941642

76642_at

8072143

87105_at

A_23_P40588

A_33_P3309231

GE87613

GO:0001671

GO:0003674

GO:0005515

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0016226

GO:0030154

GO:0042802

GO:0043226

GO:0044571

GO:0046872

GO:0048856

GO:0051087

GO:0051259

GO:0060215

GO:0060319

GO:0065003

GO:0098772

HMNXSV003009696

HMNXSV003041819

ILMN_1771921

ILMN_2184789

TC22000186.hg

g12652532_3p_x_at

Participates

as a candidate of

Mitochondrial targeting peptides (from matrix proteins) [mitochondrial matrix] (Homo sapiens)

Other forms of this molecule

HSCB [mitochondrial matrix]

HSCB(1-235) [mitochondrial inner membrane]

HSCB [mitochondrial inner membrane]

HSCB(1-235) [mitochondrial intermembrane space]

Inferred To

jac1 [mitochondrial matrix] (Schizosaccharomyces pombe)

HSCB [mitochondrial matrix] (Bos taurus)

HSCB [mitochondrial matrix] (Canis familiaris)

HSCB [mitochondrial matrix] (Gallus gallus)

HSCB [mitochondrial matrix] (Sus scrofa)

Hscb [mitochondrial matrix] (Rattus norvegicus)

HSCB(1-30) [mitochondrial matrix] (Mus musculus)

JAC1 [mitochondrial matrix] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_741999.3

OpenTargets

ENSG00000100209

ENSEMBL

ENST00000216027, ENSP00000216027

HPA

ENSG00000100209-HSCB

PRO

Q8IWL3

Pharos - Targets

Q8IWL3

HMDB Protein

HMDBP08673

PDB

3BVO

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21912 SDHB	2	SDHB [mitochondrial inner membrane] (R-HSA-70985) SDHB [mitochondrial matrix] (R-HSA-9854983)	0.813	22
UniProt:A6NFY7 SDHAF1	1	SDHAF1 [mitochondrial matrix] (R-HSA-9854988)	0.748	5
UniProt:P38646 HSPA9	6	HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.742	14
UniProt:Q5U5X0 LYRM7	1	LYRM7 [mitochondrial matrix] (R-HSA-9866252)	0.698	7
UniProt:P07814 EPRS1	1	EPRS [cytosol] (R-HSA-379649)	0.67	4
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262) AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511)	0.666	4
UniProt:Q96I99 SUCLG2	1	SUCLG2 [mitochondrial matrix] (R-HSA-156628)	0.656	4
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.643	10
UniProt:Q86SX6 GLRX5	1	GLRX5 [mitochondrial matrix] (R-HSA-2564761)	0.623	3
UniProt:P13804 ETFA	1	ETFA(1-?) [mitochondrial matrix] (R-HSA-169262)	0.613	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.558	6
UniProt:P16083 NQO2	1	NQO2 [cytosol] (R-HSA-2980908)	0.548	4
UniProt:P42694 HELZ			0.548	4
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.547	2
UniProt:Q0VDF9 HSPA14	2	HSPA14 [cytosol] (R-HSA-5251948) HSPA14 [nucleoplasm] (R-HSA-5252082)	0.547	2
UniProt:P23526 AHCY	3	AHCY [cytosol] (R-HSA-174373) AHCY W112* [cytosol] (R-HSA-5579042) AHCY Y143C [cytosol] (R-HSA-5579098)	0.547	2
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.547	2
UniProt:Q8TCS8 PNPT1	1	PNPT1 [mitochondrial matrix] (R-HSA-9836559)	0.547	2
UniProt:O00330 PDHX	1	PDHX [mitochondrial matrix] (R-HSA-70059)	0.547	2
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.482	3
UniProt:Q5JTZ9 AARS2	1	AARS2 [mitochondrial matrix] (R-HSA-379653)	0.462	2
UniProt:P53597 SUCLG1	1	SUCLG1 [mitochondrial matrix] (R-HSA-156623)	0.462	2
UniProt:Q9H845 ACAD9	1	ACAD9 [mitochondrial inner membrane] (R-HSA-5689049)	0.462	2
UniProt:P56556 NDUFA6	1	NDUFA6 [mitochondrial inner membrane] (R-HSA-59932)	0.462	2
UniProt:P47985 UQCRFS1	3	UQCRFS1(1-274) [mitochondrial matrix] (R-HSA-9906006) UQCRFS1(1-274) [mitochondrial inner membrane] (R-HSA-9906005) UQCRFS1(79-274) [mitochondrial inner membrane] (R-HSA-164278)	0.462	6
UniProt:O00217 NDUFS8	1	NDUFS8 [mitochondrial matrix] (R-HSA-6788526)	0.462	6
UniProt:P28331 NDUFS1	1	NDUFS1 [mitochondrial matrix] (R-HSA-6788513)	0.462	6
UniProt:Q9NSE4 IARS2	1	IARS2 [mitochondrial matrix] (R-HSA-379571)	0.462	2
UniProt:Q99798 ACO2	3	ACO2(1-780) [mitochondrial intermembrane space] (R-HSA-1267957) ACO2(1-780) [cytosol] (R-HSA-1267965) ACO2 [mitochondrial matrix] (R-HSA-70968)	0.462	2

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