MECP2 is phosphorylated at T308

Stable Identifier
R-HSA-8986937
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MECP2 is phosphorylated at T308
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Calcium-dependent protein kinases, PKA and CaMK IV, activated by neuronal membrane depolarization, phosphorylate MECP2 at threonine residue T308. Only the PKA C-alpha isoform (PRKACA) was experimentally tested. T308 corresponds to T320 in the longer MECP2 splicing isoform, MECP2_e1 (MECP2B). Phosphorylation of MECP2 at threonine residue T308 is correlated with neuronal activity and inhibits binding of MECP2 to the nuclear receptor co-repressor complex (NCoR/SMRT) (Ebert et al. 2013).
Literature References
PubMed ID Title Journal Year
23770587 Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR

Kastan, NR, Greenberg, ME, Ekiert, R, Bird, AP, Lyst, MJ, Hu, LS, Gabel, HW, Cohen, S, Navarro, AJ, Ebert, DH, Robinson, ND

Nature 2013
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Catalyst Activity

calcium,diacylglycerol-dependent serine/threonine kinase activity of Active PRKACA,CaMK IV [nucleoplasm]

Physical Entity
Active PRKACA,CaMK IV [nucleoplasm] (Homo sapiens)
Activity
calcium,diacylglycerol-dependent serine/threonine kinase activity (GO:0004698)
Inferred From
Active Prkaca and CaMK IV phosphorylate Mecp2 at T308 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-05-05)
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