Reactome | IL24 binds IL20RA:JAK1:IL20RB

IL24 binds IL20RA:JAK1:IL20RB

Stable Identifier

R-HSA-8986972

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Synonyms

IL24 binds to IL20RA:JAK1:IL20RB receptor complex, IL20RA:IL20RB binds IL24

ReviewStatus

5/5

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Interleukin-24 (IL24) binds a receptor complex containing Interleukin-20 Receptor subunit alpha (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) (Andoh et al. 2009, Logsdon et al. 2012) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish Novak et al.1998). Furthermore IL24 can also bind Interleukin-22 receptor subunit alpha-1 (IL22RA1) and IL20RB (Wang et al. 2002) to form a ligand receptor complex.
As it is not clear whether the receptor complex can form in the absence of ligand, formation of the receptor dimer is represented here as an uncertain event.

Literature References

PubMed ID	Title	Journal	Year
11706020	Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 Liang, P, Zhang, R, Wang, M, Tan, Z, Kotenko, SV	J. Biol. Chem.	2002
22802649	Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines Logsdon, NJ, Rajashankar, KR, Harris, BD, Deshpande, A, Walter, MR	Proc. Natl. Acad. Sci. U.S.A.	2012
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Madden, K, Chandrasekher, YA, Yao, L, Brandt, C, Foster, DC, Jelinek, L, Brender, T, McKernan, PA, Jaspers, S, West, J, Jones, C, Parrish-Novak, J, Xu, W	J Biol Chem	2002