IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3

Stable Identifier
Reaction [transition]
Homo sapiens
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Signal transducer and activator of transcription 5A and 5B (STAT5A, STAT5B) is phosphorylated after binding the Interleukin-20 (IL20) receptor complex, which consist of IL20, Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-20 receptor subunit beta (IL20RB), phosphorylated Tyrosine-protein kinase JAK2 (JAK2), Tyrosine-protein kinase JAK3 (JAK3) and STAT5. After IL20 stimulation STAT5 is phosphorylated at Tyr-694 (Tritsaris et al. 2007). It is not clear which kinase subunit of the receptor complex is responsible for STAT5 phosphorylation.

Literature References
PubMed ID Title Journal Year
17878297 IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs

Jia, T, Myren, M, Olsen, UB, Hansen, AJ, van der Blom, I, Ditlev, SB, Dissing, S, Cao, Y, Zhang, J, H├╝bschmann, MV, Tritsaris, K, Cao, R, Wahlberg, E

Proc. Natl. Acad. Sci. U.S.A. 2007
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3:STAT3 [plasma membrane]

Orthologous Events
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